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Urinary extracellular vesicles (uEV) are a largely unexplored source of kidney-derived mRNAs with potential to serve as a liquid kidney biopsy. We assessed ∼200 uEV mRNA samples from clinical studies by genome-wide sequencing to discover mechanisms and candidate biomarkers of diabetic kidney disease (DKD) in Type 1 diabetes (T1D) with replication in Type 1 and 2 diabetes. Sequencing reproducibly s

Bakgrund: WHO klassar vaccinationsmotstånd som ett av de största hoten mot folkhälsan i modern tid. COVID-19 drabbade världen med stor kraft och vaccination var en förutsättning för att kunna återfå ett fungerande samhälle. Samtidigt sågs en utbredd vaccinationstveksamhet. Sjuksköterskor möter vaccintveksamma personer och för att kunna bemöta och vägleda dem till god hälsa är det viktigt att först

Alexander Paulsson, Henrik Rahm, Niklas Sandell och Peter Svensson harstuderat bolagsstämman som ett kulturfenomen. Denna artikel bygger påden nyligen publicerade boken ”Bolagsstämman – ritualer, kultur, normeroch språk” i vilken börsnoterade företags bolagsstämmor tolkas sombetydelsefulla ekonomiska ritualer.

Neighborhood support can improve aging in place for older adults, but research on the role of public housing staff in supporting older tenants is lacking. Twenty-nine participants (janitors, n = 11; maintenance staff, n = 18) collected data about critical situations among older tenants residing in apartments in Sweden. Modifying the Critical Incident Technique (CIT) and applying a mixed-methods de

The accompanying code is the backend of a toponym disambiguation tooldeveloped and employed for the purpose of the following article: https://zenodo.org/record/7418864It has been assembled by a range of open-source tools, so anyone interestedcan simply clone this repository and apply it to their own needs.If you do, we kindly ask that you cite the abovementioned article/paper andthis repository.In

The aqueous humor actively interacts with the trabecular meshwork (TM), juxtacanalicular tissue (JCT), and Schlemm's canal (SC) through a dynamic fluid-structure interaction (FSI) coupling. Despite the fact that intraocular pressure (IOP) undergoes significant fluctuations, our understanding of the hyperviscoelastic biomechanical properties of the aqueous outflow tissues is limited. In this study,

This text deals with the analysis of the removal of the monument to Soviet Marshal Ivan Konev from the Prague 6 district, an important part of the capital of the Czech Republic. The given monument was built during the Soviet occupation of Czechoslovakia in 1980 and removed in 2020. The primary reason for the removal was the dissatisfaction of the political representation of Prague 6 and the leader

Inom matindustrin och djurfoderindustrin finns det stor potential för användning av tång som näringsrikt födoämne. Palmaria palmata (P. Palmata), eller i vardagligt tal, dulse är ett rött sjögräs med högt proteininnehåll (8-35%), som innehåller många mineraler som t.ex. jod och är rikt på fiber. Den vanligaste polysackariden i dulse är xylan. Vetenskapliga artiklar föreslår att xylan är delvis bunSeaweed an unexploited nutritional source with potential in human food and animal feed industry. Seaweed has a great potential within human food and animal feed industry. Seaweed in food is the most important utilization area of acro algae today. It can be used as direct consumption, functional foods and as additives such as carrageen, alginates and agar. Dulse is a red seaweed which has a high pr

Telomeres, the guardians of the chromosomes Telomeres are structures found at the end of eukaryotic chromosomes. They are composed of a repetitive DNA sequence and proteins, and their main function is to protect the chromosome ends. In human somatic cells telomeres shorten with each cell division, acting as a biological clock of cell aging. However, cancer cells are able to divide infinitely by r

For animals to survive until reproduction, it is crucial that juveniles successfully detect potential predators and respond with appropriate behavior. The recognition of cues originating from predators can be innate or learned. Cues of various modalities might be used alone or in multi-modal combinations to detect and distinguish predators but studies investigating multi-modal integration in p

Vid sidan av strävan att uppnå AI-modeller som kan skapa extremt verklighetstrogna texter och bilder existerar även målet att kunna generera mänskligt tal. Målet med detta område, kallat "talsyntes", är att skapa en syntetisk mänsklig röst som har förmågan att läsa upp en given text. Detta kan t.ex. användas i automatiserad kundtjänst eller för personliga assistenter. Själva problemet haThe emergence of machine learning based text-to-speech systems have made fully automated customer service voice calls, spoken personal assistants, and the creation of synthetic voices seem well within reach. However, there are still many technical challenges with creating such a system which can generate audio quickly and of high enough quality. One critical component of the typical text-to-speech

High hyperdiploid acute lymphoblastic leukemia (HeH ALL), one of the most common childhood malignancies, is driven by nonrandom aneuploidy (abnormal chromosome numbers) mainly comprising chromosomal gains. In this study, we investigate how aneuploidy in HeH ALL arises. Single cell whole genome sequencing of 2847 cells from nine primary cases and one normal bone marrow reveals that HeH ALL generall

HyperSurfaces (HSFs) comprise structurally reconfigurable metasurfaces whose electromagnetic properties can be changed via a software interface, using an embed- ded miniaturized network of controllers, enabling novel capabilities in wireless communications, including 5G applications. Resource constraints associated with a hardware testbed of this breakthrough technology, currently under developmen