The structure and organization of a tumor and its microenvironment are often associated with cancer outcomes due to spatially varying molecular composition and signaling. A persistent challenge is to use this physical and chemical spatial organization to understand cancer progression. Here, we present a high-definition infrared imaging–based organizational measurement framework (INFORM) that lever

BACKGROUND: Many children with juvenile idiopathic arthritis (JIA) have autoantibodies, targeting nuclear components (anti-nuclear antibodies, ANA). ANA in JIA is associated with uveitis, an eye inflammation which may cause permanent vision impairment if not detected and treated. However, ANA-testing is neither specific nor sensitive enough to be a clinically reliable predictor of uveitis risk, an

This article discusses the reconfiguration of citizenship education in the Swedish Boy Scout movement, one of the country’s largest civil society organizations, after 1945. Citizenship education was a core feature of scouting since its establishment during the first decades of the twentieth century, with patriotism and practical helpfulness as core tenets. Additionally, an emphasis on hiking and cThis article discusses the reconfiguration of citizenship education in the Swedish Boy Scout movement, one of the country’s largest civil society organizations, after 1945. Citizenship education was a core feature of scouting since its establishment during the first decades of the twentieth century, with patriotism and practical helpfulness as core tenets. Additionally, an emphasis on hiking and c

Wetlands are valuable natural capital and sensitive ecosystems facing significant risks from anthropogenic and climatic stressors. An assessment of the environmental risk levels for wetlands’ dynamic ecosystems can provide a better understanding of their current ecosystem health and functions. Different levels of environmental risk are defined by considering the categories of risk and the probabil

Bidraget visar hur man i retorikutbildning kan stödja studenters livslånga lärande och förmåga till egen kompetensutveckling. Skriftliga reflektioner lyfts fram som ett didaktiskt redskap och samarbete med arbetslivskoordinator som ett sätt att stärka utbildningens relevans och överbrygga gränsen mellan utbildning och yrkesliv.

BACKGROUND: Diabetes is associated with inner ear dysfunction. Furthermore, C57BL/6J mice fed high fat diet (HFD), a model for insulin resistance and diabetes, develop endolymphatic hydrops (EH).AIM: Evaluate if betahistine, spironolactone (aldosterone antagonist) and empagliflozin (sodium -glucose cotransporter2 inhibitor) can prevent EH induced by HFD and explore potential mechanisms.METHODS: C5

Background: Cancer immunity is based on the interaction of a multitude of cells in the spatial context of the tumour tissue. Clinically relevant immune signatures are therefore anticipated to fundamentally improve the accuracy in predicting disease progression. Methods: Through a multiplex in situ analysis we evaluated 15 immune cell classes in 1481 tumour samples. Single-cell and bulk RNAseq data

This dissertation consists of three self-contained papers in the economics of education. The first chapter examines the effect of more informative feedback on student performance. Using a difference-in-discontinuity research design and data on the population of Swedish school children, we exploit a reform which introduced a more granular grading scale and thus provided students with more informati

Presents new conceptualization of legitimacy crises in global governanceOffers new theoretical ideas on legitimacy crises as activation that can yield positive as well as negative consequencesProvides a comparative assessment of legitimacy crises and their consequences in 32 international organizations and across three decadesDevelops in-depth insights on the legitimacy crises of the WTO and the U

Sanfilippo C syndrome (Mucopolysaccharidosis IIIC) is a rare lysosomal storage disorder caused by mutations in the HGSNAT gene. It is characterized by a progressive and severe neurodegeneration, for which there is no treatment available. Here, we report the generation of two HGSNAT-mutated cell lines from a healthy human induced pluripotent stem cell (hiPSC) line using CRISPR/Cas9 editing. These n

Direct cellular reprogramming has recently gained attention of cancer researchers for the possibility to convert undifferentiated cancer cells into more differentiated, postmitotic cell types. While a few studies have attempted reprogramming of glioblastoma (GBM) cells toward a neuronal fate, this approach has not yet been used to induce differentiation into other lineages and in vivo data on redu

Fifteen correlated α-decay chains starting from the odd-A superheavy nucleus 289Fl were observed following the fusion-evaporation reaction 48Ca+244Pu. The results call for at least two parallel α-decay sequences starting from at least two different states of 289Fl. This implies that close-lying levels in nuclei along these chains have quite different spin-parity assignments. Further, observed α-el

Flerovium isotopes (element Z = 114) were produced in the fusion-evaporation reactions 48Ca+242,244Pu and studied with an upgraded TASISpec decay station placed in the focal plane of the gas-filled separator TASCA at the GSI Helmholtzzentrum für Schwerionenforschung in Darmstadt, Germany. Twenty-nine flerovium decay chains were identified by means of correlated implantation, α decay, and spontaneo