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Long-Term Outcome of Graves’ Disease : A Gender Perspective

Introduction: In gender-skewed conditions such as Graves’ disease (GD), the outcome naturally becomes dominated by the majority. This may lead to gender-biased misunderstandings regarding treatment outcomes. This especially holds true when complications, such as depression, are unevenly distributed. We have, therefore, studied the long-term outcome of GD from a gender perspective. Materials and Me

Weekly pain trajectories among people with knee or hip osteoarthritis participating in a digitally delivered first-line exercise and education treatment

OBJECTIVE: Digital self-management programs are increasingly used in the management of osteoarthritis (OA). Little is known about heterogeneous patterns in response to these programs. We describe weekly pain trajectories of people with knee or hip OA over up to 52-week participation in a digital self-management program.METHODS: Observational cohort study among participants enrolled between January

Pollination supply models from a local to global scale

Ecological intensification has been embraced with great interest by the academic sector but is still rarely taken up by farmers because monitoring the state of different ecological functions is not straightforward. Modelling tools can represent a more accessible alternative of measuring ecological functions, which could help promote their use amongst farmers and other decision-makers. In the case

CGG toolkit : Software components for computational genomics

Public-domain availability for bioinformatics software resources is a key requirement that ensures long-term permanence and methodological reproducibility for research and development across the life sciences. These issues are particularly critical for widely used, efficient, and well-proven methods, especially those developed in research settings that often face funding discontinuities. We re-lau

The role of 18F-fluoromethylcholine-positron emission tomography-computed tomography for preoperative localization of hyperfunctioning parathyroid glands with special emphasis on multiglandular disease : a retrospective cohort study

Background: Primary hyperparathyroidism (PHPT) is a common endocrine disorder. Definitive treatment is surgical. Preoperative localization of diseased glands increases the chance of successful treatment. The aim of this study is to investigate the diagnostic performance of 18F-fluoromethylcholine-positron emission tomography-computed tomography (18F-FCh-PET-CT) in preoperative localization of dise

A Study of Chinese Youth’s Immigration Motivation in the Post-pandemic Era

This thesis examined the motivation for Chinese youth to immigrate in the post-pandemic era. The Covid-19 pandemic had a significant impact on Chinese economics, society, and political environment. This paper aimed to understand how these factors had influenced the immigration decisions of Chinese youth. The research adopted qualitative methods and gathered data from interviews with nine young mai

Secondary malignancies among mantle cell lymphoma patients

Purpose: With modern treatments, mantle cell lymphoma (MCL) patients more frequently experience long-lasting remission resulting in a growing population of long-term survivors. Follow-up care includes identification and management of treatment-related late-effects, such as secondary malignancies (SM). We conducted a population-based study to describe the burden of SM in MCL patients. Methods: All

Quinolone Prophylaxis in Conjunction with Bacillus Calmette-Guérin Instillations for Bladder Cancer : Time To Reconsider the Evidence and Open the Quinolone Box?

Adjuvant bacillus Calmette-Guérin (BCG) instillations represent a cornerstone in the treatment of non–muscle-invasive bladder cancer. Instillation schedule and dose modifications have been evaluated in efforts to reduce the incidence of adverse events (AEs), but none so far has the same treatment efficacy as the full-dose recommended schedule. It has been shown that prophylactic quinolone use in c

An efficient system matrix factorization method for scanning diffraction based strain tensor tomography

Diffraction-based tomographic strain tensor reconstruction problems in which a strain tensor field is determined from measurements made in different crystallographic directions are considered in the context of sparse matrix algebra. Previous work has shown that the estimation of the crystal elastic strain field can be cast as a linear regression problem featuring a computationally involved assembl

Det blå cykel-cafét - En plats i rörelse

I södra utkanten av Lomma, längs den långgrunda bukten sträcker sig Öresundsparken. En kort promenad från Alnarp mellan böljande fält. På andra sidan svänger Malmövägen över landskapet. Bakom fyra upprätta flaggstänger ligger ett ljusblått vägcafé. Skylten finns kvar men fönstren är igenspikade. Verksamheten satt på paus. Mellan plattsättningen börjar smala björkar tränga upp. Ljudet av svischandeOn the southern side of Lomma, along the dunes in the shallow bay, stretches Öresundsparken. A short walk from Alnarp between fields waving in the wind. On the other side, Malmövägen makes its way along the coast. Behind four upright flagpoles lies a bright blue road cafe. The sign is still there but the windows are all closed off. Between the tiles, slim birches are beginning to grow. The sound o

Fluorescence Microscopy of Nanochannel-Confined DNA

Stretching of DNA in nanoscale confinement allows for several important studies. The genetic contents of the DNA can be visualized on the single DNA molecule level, and the polymer physics of confined DNA and also DNA/protein and other DNA/DNA-binding molecule interactions can be explored. This chapter describes the basic steps to fabricate the nanostructures, perform the experiments, and analyze

Mirroring the Masses? A Cross-National Comparison of Civil Society Elite Composition

This chapter explores the composition of civil society elites and to what extent this differs from the general population, what we call the ‘civil society elite-masses gap’. While the civil society elites are, from a normative point of view, expected to be representative of the general population in terms of their social composition and attitudes, professionalisation and elitisation of civil socie

Introduction: Advancing a New Research Agenda on Digital Disruption in Diplomacy

This article introduces the special issue on digital disruption in diplomacy. We propose a new research agenda, advancing novel conceptualisations and empirical insights into the hybrid nature of contemporary diplomatic practices in a broad range of areas such as peace-making, inter-state signalling, domestic politics, digital communication, public diplomacy and popular culture. Emphasising the ma

Efficient Time-of-Arrival Self-Calibration using Source Implicitization

In this paper we revisit the Time-of-Arrival self-calibration problem. In particular we focus on imbalanced problem instances where there are significantly more sources compared to the number of receivers, which is a common configuration in real applications. Using an implicit representation, we are able to re-parameterize the sensor node self-calibration problem using only the parameters of the r

Serine racemase modulation for improving brain insulin resistance : An Editorial Highlight for “Deletion of serine racemase reverses neuronal insulin signaling inhibition by amyloid-β oligomers”

This Editorial highlights an interesting study in the current issue of the Journal of Neurochemistry in which Zhou et al. report new data showing that the ablation of serine racemase increases local insulin production in neurons of the hippocampus. The authors explored some of the possible mechanisms mediating the interaction between dampening production of D-serine and the local synthesis of insu

Modification of purinergic signaling in the hippocampus of streptozotocin-induced diabetic rats

Diabetic encephalopathy is a recognized complication of untreated diabetes resulting in a progressive cognitive impairment accompanied by modification of hippocampal function. The purinergic system is a promising novel target to control diabetic encephalopathy since it might simultaneously control hippocampal synaptic plasticity and glucose handling. We now tested whether streptozotocin-induced di

Stochastic Geometry Analysis of a New GSCM with Dual Visibility Regions

The geometry-based stochastic channel models (GSCM), which can describe realistic channel impulse responses, often rely on the existence of both local and far scatterers. However, their visibility from both the base station (BS) and mobile station (MS) depends on their relative heights and positions. For example, the condition of visibility of a scatterer from the perspective of a BS is different

Improving rates of successful extubation : Medications

This chapter focuses on the pharmacological management of newborn infants in the peri-extubation period to reduce the risk of re-intubation and prolonged mechanical ventilation. Drugs used to promote respiratory drive, reduce the risk of apnoea, reduce lung inflammation and avoid bronchospasm are critically assessed. When available, Cochrane reviews and randomised trials are used as the primary so