Galectins play biological roles in immune regulation and tumor progression. Ligands with high affinity for the shallow, hydrophilic galectin-3 ligand binding site rely primarily on a galactose core with appended aryltriazole moieties, making hydrophobic interactions and π-stacking. We designed and synthesized phenyl sulfone, sulfoxide, and sulfide-triazolyl thiogalactoside derivatives to create af

Rare-earth (RE) doped optical materials are distinguished by their unique optical and electronic properties. These characteristics are essential for various applications, including laser stabilization, and phosphors. However, the sensitivity of these materials to environmental factors and intrinsic defects necessitates a deep understanding. Grasping how these factors influence the refractive index

Time-resolved x-ray solution scattering (TR-XSS) is a sub-field of structural biology, which observes secondary structural changes in proteins as they evolve along their functional pathways. While the number of distinct conformational states and their rise and decay can be extracted directly from TR-XSS experimental data recorded from light-sensitive systems, structural modeling is more challengin

Objective: To investigate how a behavioral health, artificial intelligence (AI)-powered, digital self-management tool affects the daily functions in adults with chronic back and neck pain. Design: Eligible subjects were enrolled in a 12-week prospective, multicenter, single-arm, open-label study and instructed to use the digital coach daily. Primary outcome was a change in Patient-Reported Outcome

Wireless charging of smartphones using inductive wireless power transfer (IWPT) has become very popular. However, the efficiency of IWPT systems can decrease substantially when the transmitting and receiving coils are not closely coupled. One popular approach to mitigate the efficiency degradation is to utilize higher frequency. However, the higher efficiency is only achieved at a specific range o

Dark matter’s presence can be inferred from gravitational interactions and astrophysical observations, but its nature is still unknown. If dark matter is a particle, then we hope to complement these observations from space and understand its nature and interactions by producing it in controlled laboratory conditions. The Large Hadron Collider (LHC), hosted at the CERN laboratory in Switzerland, pr

The human chaperone DNAJB6b increases the solubility of proteins involved in protein aggregation diseases and suppresses the nucleation of amyloid structures. Due to such favourable properties, DNAJB6b has gained increasing attention over the past decade. The understanding of how DNAJB6b operates on a molecular level may aid the design of inhibitors against amyloid formation. In this work, fundame

This paper presents an overview of animals depicted within the Swedish concession area of Gebel el-Silsila and Shatt el-Rigal, spanning the Prehistoric tothe early Islamic period. It includes commentaries on stylistic, technical andchronological phases of the rock art, and present an overview of distributionpatterns as well as a relative taxonomic morphology for the more frequentmotifs. Main emphaThis paper presents an overview of animals depicted within the Swedish con-cession area of Gebel el-Silsila and Shatt el-Rigal, spanning the Prehistoric to the early Islamic period. It includes commentaries on stylistic, technical and chronological phases of the rock art, and present an overview of distribution patterns as well as a relative taxonomic morphology for the more frequent motifs. Main

The change in constituent order in English is one of the most thoroughly investigated changes in the history of the English language. Even so, there is still disagreement among scholars as to what caused the change. The aim of this article is to argue that it was the influence of the Scandinavians and their language, Old Norse, that caused English to abandon the SOV constituent order and instead a

Environmental exposure to noise and particle matter (PM) are risk factors for cardiovascular disease (CVD). Although there are often higher levels in occupational settings, little is known about noise and particle exposures at work and CVD risks. We investigated occupational noise and particle exposures and acute effects on pulse rate and blood pressure. 46 active, non-smoking, male construction w

Objective: The first-line approach for childhood obesity is lifestyle intervention (LI); however, success varies. This study aimed first to identify distinct subgroups of response in children living with overweight and obesity and second to elucidate predictors for subclusters. Methods: Based on the obesity patient follow-up registry the APV (Adipositas-Patienten-Verlaufsdokumentation) initiative,

Context. TOI-1055 is a Sun-like star known to host a transiting Neptune-sized planet on a 17.5-day orbit (TOI-1055 b). Radial velocity (RV) analyses carried out by two independent groups using nearly the same set of HARPS spectra have provided measurements of planetary masses that differ by ∼2σ. Aims. Our aim in this work is to solve the inconsistency in the published planetary masses by significa

Background and ObjectivesWhile chronological age is one of the most influential determinants of poststroke outcomes, little is known of the impact of neuroimaging-derived biological "brain age."We hypothesized that radiomics analyses of T2-FLAIR images texture would provide brain age estimates and that advanced brain age of patients with stroke will be associated with cardiovascular risk factors a

Lytic polysaccharide monooxygenases (LPMOs) are surface-active redox enzymes that catalyze the degradation of recalcitrant polysaccharides, making them important tools for energy production from renewable sources. In addition, LPMOs are important virulence factors for fungi, bacteria, and viruses. However, many knowledge gaps still exist regarding their catalytic mechanism and interaction with the

Recent scandals in Iran's province of Gilan have exposed a deep-seated hypocrisy within the Islamic regime, revealing a contradiction between public moral posturing and private conduct.High-ranking officials have been caught in explicit acts, leading to public outrage. These scandals are not isolated incidents but reflect a systemic failure to uphold Islamic laws and moral codes, calling into ques

The exponential growth of converging technologies, including augmented reality, autonomous vehicles, machine-to-machine and machine-to-human interactions, biomedical and environmental sensory systems, and artificial intelligence, is driving the need for robust infrastructural systems capable of handling vast data volumes between end users and service providers. This demand has prompted a significa

Small cell lung cancer (SCLC) is characterized by rapid growth and high metastatic capacity. It has strong epidemiologic and biologic links to tobacco carcinogens. Although the majority of SCLCs exhibit neuroendocrine features, an important subset of tumors lacks these properties. Genomic profiling of SCLC reveals genetic instability, almost universal inactivation of the tumor suppressor genes TP5