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Stakeholder Perspectives on Built Environmental Factors to Support Stroke Rehabilitation and Return to Everyday Life

BACKGROUND: The transition to undertaking rehabilitation in the home or local neighbourhood calls for an extensive understanding of which aspects of the built environment are important for people with stroke.OBJECTIVE: This qualitative study aims to explore how home and local neighbourhood environments support or hinder rehabilitation for people who have had a stroke from the perspectives of vario

Predictions, uncertainty, and collective epistemic work : How projected futures informed and misinformed enactments of Covid-19

By connecting an uncertain present to a potential future, predictions and other forms of projected futures construct meaningful contexts on which actors can lean when seeking to act in the face of uncertainty. This article outlines the background and careers of many, and often contradicting, futures that informed the collective work to define and represent Covid-19 in Sweden during the first half

Complement factors as biomarkers in ANCA-associated vasculitis in remission

Background Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a group of rare, autoimmune diseases causing inflammation in the vessel wall. Many organs can be affected, and kidney involvement is a common and serious manifestation. Complement activation is important in disease development and has also been detected in patients in remission. The reason for increased complemen

The plasma proteome reveals distinct signaling pathways associated with PR3-ANCA positive and MPO-ANCA positive vasculitis

OBJECTIVE: Despite recent advances, the pathophysiological mechanisms underlying anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitides (AAV) remain incompletely understood, and comparative proteomic analyses of AAV subtypes are lacking. This study aimed to identify key molecular signaling pathways activated in AAV and to elucidate molecular distinctions between AAV with proteinase 3

Assessing symptom improvement in patients with postural orthostatic tachycardia syndrome (POTS) following a 16-week structured exercise programme : a protocol for a randomised cross-over trial in a clinical outpatient setting

INTRODUCTION: Exercise training is recommended as a complementary treatment in postural orthostatic tachycardia syndrome (POTS) according to international guidelines. However, less is known regarding how exercise training could successfully be implemented in clinical practice in patients with POTS. Thus, in the current study, we aim to assess the effect of a 16-week tailored exercise training prog

Rock Inscriptions above the Speos at Gebel el-Silsila

The present paper aims to serve as an initial publication focusing on a collection of rock inscriptions situated in the north-eastern cliff, positioned above and to the right of the façade of the renowned Speos at Gebel el-Silsila. Its purpose is to offer a preliminary glimpse into a comprehensive compilation of rock inscriptions from the area, presently being prepared for publication. Within this

The Association between Antenatal SARS-CoV-2 Exposure and Infant Neurodevelopment at Four Months of Age : A Prospective Multicenter Cohort Survey within the COPE Study

OBJECTIVES: It remains unclear whether antenatal SARS-CoV-2 exposure affects subsequent infant neurodevelopment. We aimed to investigate the association between antenatal maternal SARS-CoV-2 infection and neurodevelopment in four-month-old infants.METHODS: Data was collected within the prospective multicenter COVID-19 during pregnancy and early childhood study, COPE (NCT04433364). Infants exposed

Exploring the Driver’s Mental Control Model : Concepts and Insights

This study aims to develop a comprehensive model that accurately represents the perceptual system of drivers and provides insights into their behavior. Existing models, namely the Skill-Rule-Knowledge model and the dynamic driving task model, were integrated. This integrated model successfully elucidates the sequential processes involved in sensation reception, recognition, judgment, and control.

Development of Human-Vehicle Interaction Models and Human-in-the-loop Evaluation Framework Considering Levels of Automated Driving

Human-Vehicle Interaction (HVI) evaluations encompass a wide range of aspects and typically follow a structured process from problem definition to conclusion. This research was motivated by two key challenges emerging from this process. First, there is a need to explain user behavior more comprehensively, going beyond mere system evaluation. Second, there is a consistent demand for a systematic hu

Evaluation of Display Configuration and Seat Orientation Considering Various Automated Driving Situations Using a Vehicle Simulator

This study examines vehicle interiors in terms of display configuration and seat orientation from a user experience viewpoint using a driving simulator. Sixteen volunteers were sat in the driver’s seat to evaluate visibility and mental comfort scores of three display configurations used in the vehicle (i.e., floating, flush, and large display). Another sixteen volunteers were sat in the passenger’

Effect of multimodal takeover request issued through A-pillar LED light, earcon, speech message, and haptic seat in conditionally automated driving

The driver of a conditionally automated vehicle equivalent to level 3 of the SAE is obligated to accept a takeover request (TOR) issued by the vehicle. Considerable research has been conducted on the TOR, especially in terms of the effectiveness of multimodal methods. Therefore, in this study, the effectiveness of various multimodalities was compared and analyzed. Thirty-six volunteers were recrui

Development of Warning Methods for Planned and Unplanned Takeover Requests in a Simulated Automated Driving Vehicle

In several circumstances, a level-three automated vehicle cannot continue driving in an automated driving mode and requests a human driver to take over. In this study, a series of experiments to examine how to provide a TOR was conducted. First, for forty-one persons, a HUD icon, earcon, seat vibration, and combinations were compared. The results indicated that the HUD icon-earcon and HUD icon-sea

Genome-Wide Association Study Meta-Analysis of 9619 Cases With Tic Disorders

BACKGROUND: Despite the significant personal and societal burden of tic disorders (TDs), treatment outcomes remain modest, necessitating a deeper understanding of their etiology. Family history is the biggest known risk factor, and identifying risk genes could accelerate progress in the field.METHODS: Expanding upon previous sample size limitations, we added 4800 new TD cases and 971,560 controls

Mixed micellar solutions of an oleo-furan sulfonate surfactant with anionic and non-ionic surfactants

Small angle neutron scattering (SANS) has been employed to examine the self-assembly behaviour of sodium 5-tetradecyl furan-2-sulfonate (STFS), an emerging anionic surfactant, in bulk dilute solutions. STFS was also studied in binary and ternary mixtures with a common non-ionic (hexaethylene glycol monododecyl ether, C12E6) and anionic (sodium dodecyl sulfate, SDS) surfactant to explore the shape,

Surfactant effects on the synthesis of oxide nanoparticles using deep eutectic solvents

In this work we report the solvothermal synthesis of iron oxide and zinc oxide using a ternary eutectic mixture of choline chloride, urea and glycerol at three molar ratio of the components 1 : 1 : 1, 1 : 1.5 : 0.5 and 1 : 0.5 : 1.5. The synthesised iron oxide is nanocrystalline with a crystallite size of 67.5 ± 8.9 nm, however ZnO formed larger particles. Water and surfactants can be added to the