Background: The prospective, multinational European 'Stroke in Young Fabry Patients' (sifap1) study collected 4,467 patients with acute ischemic cerebrovascular events aged 18-55 years. Initially, aetiologic subtyping was performed using the TOAST classification; however, recently the phenotypic ASCO classification was presented and might be more useful to identify stroke aetiologies in young pati

We show that the formation of the wetting layer and the experimentally observed continuous shift of the H2O-OH balance toward molecular water at increasing coverage on a TiO2(110) surface can be rationalized on a molecular level. The mechanism is based on the initial formation of stable hydroxyl pairs, a repulsive interaction between these pairs, and an attractive interaction with respect to water

In this paper, we propose the hypothesis that cash flow and cash flow volatility predict returns. We categorize firms listed on the New York Stock Exchange into sectors, and apply tests for both in-sample and out-of-sample predictability. While we find strong evidence that cash flow volatility predicts returns for all sectors, the evidence obtained when using cash flow as a predictor is relatively

Glutaraldehyde (GA) reacts with amino groups in proteins, forming intermolecular cross-links that, at sufficiently high protein concentration, can transform a protein solution into a gel. Although GA has been used as a cross-linking reagent for decades, neither the cross-linking chemistry nor the microstructure of the resulting protein gel have been clearly established. Here we use small-angle X-r

G protein-coupled estrogen receptor 1 (GPER1), previously named GPR30, is a membrane receptor reported to mediate nongenomic estrogen responses. We investigated if GPER1 expression correlates with any clinicopathologic variables and distant disease-free survival (DDFS) in patients with breast cancer, if any prognostic impact of the receptor is dependent on estrogen receptor-α (ER-α) status, and if

Introduction: Dead space negatively influences carbon dioxide (CO2) elimination, particularly at high respiratory rates (RR) used at low tidal volume ventilation in acute respiratory distress syndrome (ARDS). Aspiration of dead space (ASPIDS), a known method for dead space reduction, comprises two mechanisms activated during late expiration: aspiration of gas from the tip of the tracheal tube and

Alarmins S100A8/A9 regulate pathology in experimental osteoarthritis (OA). Paquinimod is an immunomodulatory compound preventing S100A9 binding to TLR-4. We investigated the effect of paquinimod on experimental OA and human OA synovium.

Mammographic density is an established risk factor for breast cancer; however, the relation to tumor pathological parameters including the androgen receptor and molecular subtypes has not been extensively studied.

The PHENIX collaboration at the Relativistic Heavy Ion Collider (RHIC) reports measurements of azimuthal dihadron correlations near midrapidity in d + Au collisions at root s(NN) = 200 GeV. These measurements complement recent analyses by experiments at the Large Hadron Collider (LHC) involving central p + Pb collisions at root s(NN) = 5.02 TeV, which have indicated strong anisotropic long-range c

This paper describes the development of a method based on measurements of the radar cross section (RCS) amplitude and phase in the forward direction to determine the extinction cross section for the 2.5 GHz - 38 GHz frequency range using the optical theorem. Forward RCS measurements are technically complicated due to that the direct signal has to be subtracted from the total signal at the receivin

To assess knee cartilage quality and subjective knee function, 20 years after injury in anterior cruciate ligament (ACL) injured copers.

Serum-mediated phagocytosis of antibody- and complement-opsonized necrotic cell material (NCM) by polymorphonuclear leukocytes can be quantified by using a flow cytometry–based assay. The phagocytosis of necrotic cell material (PNC) assay parallels the well-known lupus erythematosus cell test. In this study, we aimed to investigate the diagnostic accuracy of the assay and the relationship with cli

The objective of this work was to quantify comparisons between several computational results and measurements performed during a pool fire scenario in a well-confined compartment. This collaborative work was initiated under the framework of the OECD fire research program and involves the most frequently used fire models in the fire community, including field and zone models. The experimental scena

A Baeyer-Villiger monooxygenase has been identified in the genome sequence of Dietzia sp. D5. Sequence similarity search revealed that the enzyme belongs to a group of BVMOs that are closely related to ethionamide monooxygenase from Mycobacterium tuberculosis (EthA). The BVMO was expressed in E. coli BL21-CodonPlus(DE3)-RP and the best expression was achieved when the E. coli cells were cultivated

Salt-induced elevation of the endogenous digitalis like sodium pump ligand marinobufagenin (MBG) in the Dahl salt-sensitive rats resulted in elevated blood pressure (BP). Here, we tested, in humans, whether MBG levels are related to ambulatory 24-h BP (ABP), controlled long-term increase of salt-intake induces changes in MBG and any salt-induced change in MBG is related to salt sensitivity.

The c. 4 km long artificial island Peberholm was constructed in 1995–1999 as a land-bridge between the tunnel and the bridge that was then built for the highway and railway across the strait of Öresund between Copenhagen (Denmark) and Malmö (Sweden). The island was mainly constructed from calcareous clay mixed with sand dug up from the bottom of the strait, but some stone and sand filling was tran

We investigated the distribution, storage and landscape partitioning of soil amorphous silica (ASi) in a central Canadian region dominated by tundra and peatlands to provide a first estimate of the amount of ASi stored in Arctic permafrost ecosystems. We hypothesize that, similar to soil organic matter, Arctic soils store large amounts of ASi which may be affected by projected climate changes and

STUDY DESIGN.: The previous Scoliosis Research Society brace study (JBJS-A, 1995) included patients with adolescent idiopathic scoliosis (AIS) with moderate curve sizes (25 degrees -35 degrees ). The Swedish patients in this study were examined in a long-term follow-up. OBJECTIVE.: The aim was to analyze and compare quality of life in adulthood between AIS patients who were only observed or treate