OBJECTIVE: A novel extended-wavelength diffuse reflectance spectroscopy (EWDRS) technique is being developed for future clinical non-invasive tumor margin delineation. In this study, the ability of EWDRS to identify the margins of pigmented skin lesions in an in vivo pig model was evaluated.MATERIALS AND METHODS: Extended-wavelength diffuse reflectance spectroscopy recordings (350-1550 nm) were ma

Background: Whole genome sequences have allowed us to have an overview of the evolution of gene repertoires. The target of the present study, the TGFβ superfamily, contains many genes involved in vertebrate development, and provides an ideal system to explore the relationships between evolution of gene repertoires and that of developmental programs.Results: As a result of a bioinformatic survey of

INTRODUCTION. The diagnosis of acute lung injury may be more robust if more accurate physiological markers can be identified. Extravascular lung water index (EVLWI) may be useful and has been shown to correlate with respiratory function and mortality in patients with sepsis and ARDS. Whether this applies to a wider population, and which index performs best, are unclear. OBJECTIVES. We hypothesized

“Commensuration” as an analytic framework for studying the expanding measuring culture in social work Teres Hjärpe, PhD, Lund University, School of Social Work, teres.hjarpe@soch.lu.se. My PhD-project in social work deals with measurements and statistics as knowledge base and source for governance of social work activities. Social workers are currently experiencing the measuring and ranking of the

Density functional theory calculations and ambient pressure X-ray photoelectron spectroscopy are used to investigate initial oxidation of Cu(100). Surface stability with respect to oxygen coverage is calculated together with O 1s core level shifts. Oxidation of Cu(100) is found to occur via the formation of a p(2 × 2) overlayer (0.25 ML) followed by a reconstructed (22 × 2)R45° -O missing-row (MR)

The world has become increasingly telecoupled through distant flows of information, energy, people, organisms, goods, and matter. Recent advances suggest that telecouplings such as trade and species invasion often generate spillover systems with profound effects. To untangle spillover complexity, we make the first attempt to develop a typology of spillover systems based on six criteria: flows from

The host defense peptide LL-37 is cytotoxic for bacteria but it has also been reported to reduce host cell viability through an intracellular mechanism. LL-37-evoked cytotoxicity may be involved in the loss of bone tissue in periodontitis which is an inflammatory disease characterized by high concentrations of LL-37 observed locally in the periodontal tissue at the inflammation process. Here, we s

Understanding communication and signalling has long been strived for in studies of animal behaviour. Many songbirds have a variable and complex song, closely connected to territory defence and reproductive success. However, the quantification of such variable song is challenging. In this paper, we present a novel, automated method for detection and classification of syllables in birdsong. The meth

The evolution of protoplanetary discs embedded in stellar clusters depends on the age and the stellar density in which they are embedded. Stellar clusters of young age and high stellar surface density destroy protoplanetary discs by external photoevaporation and stellar encounters. Here, we consider the effect of background heating from newly formed stellar clusters on the structure of protoplanet

The Transition Radiation Detector (TRD) was designed and built to enhance the capabilities of the ALICE detector at the Large Hadron Collider (LHC). While aimed at providing electron identification and triggering, the TRD also contributes significantly to the track reconstruction and calibration in the central barrel of ALICE. In this paper the design, construction, operation, and performance of t

Background: Around 0.3% of newborns will develop autoimmunity to pancreatic beta cells in childhood and subsequently develop type 1 diabetes before adulthood. Primary prevention of type 1 diabetes will require early intervention in genetically at-risk infants. The objective of this study was to determine to what extent genetic scores (two previous genetic scores and a merged genetic score) can imp

The literature on regional innovation systems emphasizes the role of the region as locus for interactive learning and knowledge exchange, stressing the importance of (geographical) proximity for innovation. Even though the importance of extra-regional knowledge is widely acknowledged, there has been only little emphasis on the particular role and the nature of global knowledge flows. The aim of th

In this paper, we study the influence of current localization on the isolation between two antennas in a compact terminal setting. The two antennas are chosen to be a monopole and a PIFA. The degree of current localization is controlled by the permittivity value of the PIFA’s dielectric loading. Both lossless and lossy cases are simulated in order to ascertain the underlying performance impact fro

Part 1: From Brain to GutThe brain is an organ with a high energy requirement. To meet this demand, the brain needs a continuous and well-regulated blood supply. In situations where the brain, or parts of the brain, does not receive sufficient blood flow injury arise. This condition, commonly known as cerebral ischemia, is prevalent in today's society. In 2015, more than 6 million people died from

Purpose: The main aim of this study was to evaluate the association of computed tomography (CT) findings at admission and bowel resection rate in patients with mesenteric venous thrombosis (MVT). It was hypothesized that abnormal intestinal findings on CT were associated with a higher bowel resection rate. Methods: Retrospective study of MVT patients treated between 2004 and 2017. CT images at adm

Aims/hypothesis: Excessive weight is a risk factor for type 2 diabetes, but its role in the promotion of autoimmune diabetes is not clear. We investigated the risk of latent autoimmune diabetes in adults (LADA) in relation to overweight/obesity in two large population-based studies. Methods: Analyses were based on incident cases of LADA (n = 425) and type 2 diabetes (n = 1420), and 1704 randomly s

Mapping free-energy landscapes has proved to be a powerful tool for studying reaction mechanisms. Many complex biomolecular assembly processes, however, have remained challenging to access using this approach, including the aggregation of peptides and proteins into amyloid fibrils implicated in a range of disorders. Here, we generalize the strategy used to probe free-energy landscapes in protein f

Objective: The aim of the study was to evaluate if associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) could increase resection rates (RRs) compared with two-stage hepatectomy (TSH) in a randomized controlled trial (RCT). Background: Radical liver metastasis resection offers the only chance of a cure for patients with metastatic colorectal cancer. Patients with colo