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Regulation of exocytosis by Ca2+ and cAMP - A study on pancreatic beta- and alpha-cells

Popular Abstract in Swedish Glukos är den främsta energikällan för de flesta celler i kroppen. Det är av stor vikt att mängden glukos hålls på en jämn nivå, eftersom framförallt våra celler i hjärnan är mycket känsliga för stora variationer av glukoshalten i blodet. Regleringen av mängden glukos i blodet kontrolleras av hormonen insulin och glukagon. Insulin utsöndras från beta-celler och glukagonType-2 diabetes is characterized by impaired insulin secretion associated with excess glucagon release. Exocytosis of insulin- or glucagon-containing granules is initiated by Ca2+-influx through voltage-dependent Ca2+-channels and is modulated by the second messengers such as cAMP. Membrane capacitance measurements were used in this study to investigate the cellular mechanisms behind cAMP-regulate

The local arena for combating poverty. Malmö, Sweden.

Reducing poverty and social exclusion is one of the main challenges for ensuring social cohesion in Europe. The research project COPE – Combating Poverty in Europe: Re-organising Active Inclusion through Participatory and Integrated Modes of Multilevel Governance’ – analyses trends of poverty and social exclusion in Europe, and examines the dynamics of minimum income protection policies that poten

Lipid Self-Assembly and Lipase Action

In this thesis the action of the Thermomyces lanuginosa lipase (TLL) on "real" substrates, that is, lipid aggregates - vesicles, micelles, emulsions, gels and liquid crystals is discussed. Even for a pure triolein, the system becomes quite complex as the lipolytic process starts, both in terms of structure and composition, involving 5 additional components - diolein (DO), monoolein (MO), oleic aci

Impedance Tuning Unit for DVB-H Front-End

When implementing low frequency antennas in small devices, e.g., mobile phones using DVB-H, a large mismatch is inevitable. If a impedance tuning unit is introduced reflection losses and noise are reduced while gain is improved. A ITU consisting of 6 switched capacitances and 2 fixed LTCC inductors is studied. Simulations show that since a VSWR = 10 mismatch is reduced to better than VSWR = 2, the

On Woven Convolutional Codes

Concatenation of several conventional convolutional encoders is a both powerful and practical method to obtain encoding schemes that are attractive for use in communication systems where very low error probabilities are needed. This thesis is devoted to woven convolutional codes, a construction where the constituent codes are woven together in a manner that resembles the structure of a fabric. A

The Altar of the Dead: a Temporary Space for Memory and Meaning in the Contemporary Urban Landscape

The week following Halloween in 2006, a cultural event called ‘The altar of the dead’ was held in an urban park in the centre of the Swedish city of Malmö. Encouraging people to contemplate a deceased loved one by leaving gifts, by reciting poems, or simply by reminiscing at a confessionless altar placed in the public park, this event invited an inquiry into the relation between nature, space, and

National Developments in the Intersection of IPR and Competition Law From Maglite to Pirate Bay

The Swedish Network for European Legal Studies is happy to announce the third volume in this series of annual publications which acts as a forum for the publication of studies on European law by Swedish scholars. The annual this year focuses on competition aspects of Intellectual property law, and contains peer-reviewed articles aimed at spreading Swedish legal research on European law to a wide i

Evolutionary and functional studies of protein H: a surface molecule of Streptococcus pyogenes

Popular Abstract in Swedish Protein H - ett bakteriellt ytprotein med förmåga att binda till olika proteiner hos människa Bakgrund I vårt dagliga liv omges vi av bakterier av många olika slag. Flertalet av dessa är normalt ofarliga och många utgör den så kallade normalfloran hos människa. En del bakterier kan under vissa förhållanden ge upphov till infektion och sjukdom, men för att åstadkomma dSeveral bacterial species express surface proteins with affinity for the Fc part of human IgG. This thesis describes evolutionary and functional studies of protein H, an IgGFc-binding surface protein of the human pathogen Streptococcus pyogenes. By using peptide mapping and NMR analysis the IgGFc-binding region of protein G, a surface protein of group C and G streptococci, was identified. Various

Adipocyte phosphatases and the antilipolytic action of insulin

Popular Abstract in Swedish Min forskning handlar om hur nedbrytningen av fett i fettceller regleras genom att fosfat tas av och sätts fast på olika proteiner inuti fettcellerna. För att man skall förstå hur fettnedbrytning hänger ihop med att fosfat reagerar med proteiner är det bra att veta något om hur fettcellernas ämnesomsättning regleras. Energilagring och fettomsättning Människokroppen laAdipose tissue is the main site of energy storage of the body and an important endocrine organ. Knowledge of the regulation of fat metabolism and the endocrine factors secreted by the adipocyte is crucial for the understanding of diseases such as obesity and diabetes. Insulin is the main antilipolytic hormone. Protein kinase B (PKB) and phosphodiesterase 3B (PDE3B) are both phosphorylated and acti