Aims: Maintainance of glucagon response to hypoglycaemia is important as a safeguard against hypoglycaemia during glucose-lowering therapy in type 2 diabetes. During recent years, DPP-4 (dipeptidyl peptidase-4) inhibition has become more commonly used in elderly patients. However, whether DPP-4 inhibition affects the glucagon response to hypoglycaemia in the elderly is not known and was the aim of

Background: Residential care homes (RCHs) are increasingly becoming a common place of death for older people. Aim: The aim of this study was to describe family members' experiences of care of the dying in RCHs where the Liverpool care pathway for the dying patient was used. Methods: This study had a descriptive qualitative study design. Fifteen (n=15) individual interviews were analysed using qual

To harvest the benefits of III-V nanowires in optoelectronic devices, the development of ternary materials with controlled doping is needed. In this work, we performed a systematic study of n-type dopant incorporation in dense InxGa(1-x)P nanowire arrays using tetraethyl tin (TESn) and hydrogen sulfide (H2S) as dopant precursors. The morphology, crystal structure and material composition of the na

Under istider, när stora mängder havsvatten var bundet i inlandsisar, var den globala havsnivån lägre än idag och stora delar av kontinentalsockeln torrlagd. Den senaste istiden (cirka 115 000–12 000 år sedan) var inget undantag, då torrlagda områden utvecklades till ekologiskt rika kustområden som möjliggjorde människans spridning över världen. När inlandsisarna smältesteg havsnivån och dessa lanDuring times of lower global sea level, vast areas of the coastal shelf were exposed and converted into ecologically diverse coastal landscapes that wereattractive for human occupation. The landscapes were subsequently flooded during the deglaciation, but well-preserved remains of these landscapes andtheir inhabitants can today be found on the seafloor. In the southern Baltic Basin, where the comp

Background: The aim of this study was to investigate the oxygen consumption of explanted aerobically-perfused cardioplegic porcine hearts at different temperatures. Material/Methods: Explanted hearts from 30 pigs weighing 50 kg were randomized into 5 groups. The hearts received continuous antegrade perfusion within a temperature-controlled sealed system. The perfusate consisted of an albumincontai

Background/Aims: Hemodialysis implies significant alterations in the profile of serum components. microRNAs (miRNAs) are present in the human serum and are considered to target distant tissues where they can regulate gene expression, thus affecting homeostasis. Whether hemodialysis alters the profile of miRNAs in the serum is not known. Methods: miRNA profiling in serum samples collected before an

The education–fertility relationship is a central element of the models explaining the transition to sustained economic growth. But many determinants of this relationship have not yet received more systematic attention. In this paper, we apply a three-stages least-squares estimator on French county-level data, including newly collected data, to better understand the causal effects running from edu

BACKGROUND AND AIM Non-stop stair ascending at maximum speed is required to reach a safe refuge level from deep underground structures, such as subways and in high-rise buildings in an emergency evacuation situation. Endurance of stair climbing and identifying the time of the onset of leg’s local muscle fatigue (LMF) are interests in evacuation research. The objective of this laboratory study was

Many pathogenic bacteria utilise sialic acids as an energy source or use them as an external coating to evade immune detection. As such, bacteria that colonise sialylated environments deploy specific transporters to mediate import of scavenged sialic acids. Here, we report a substrate-bound 1.95 Å resolution structure and subsequent characterisation of SiaT, a sialic acid transporter from Proteus

We study the spectrum of generalized Cesàro operators Tg acting on the class of growth spaces A- α. We show how the problem of determining the spectrum is related to boundedness of standard weighted Bergman projections on weighted L∞-spaces. Using this relation we establish some general spectral properties of these operators, and explicitly compute the spectrum for a large class of symbols g.

This population-based time-trend study examines gun violence rates among males in Sweden during the years 1996 to 2015 and compares the rate in Sweden to other Western European countries. Data were collected from six registries and are presented descriptively per 100,000 inhabitants. The risks among males in Sweden increased considerably in both lethal and non-lethal gun victimization and perpetra

Hematopoietic stem cells (HSCs) play a central role in hematopoietic regeneration, which has been demonstrated by thorough studies. In contrast, the cell cycle status and metabolic condition of HSCs define these cells as dormant. Recent studies have also revealed that protein metabolism is quite unique, as dormant HSCs have a lower protein synthesis rate and folding capacity. Under proliferative c

Rapporten är en analys av Malmö, Mölndals, Norrköpings och Örebros arbete med cykelplanering och bygger på en genomgång av plandokument från 2000 fram till 2015. Utifrån en nyckelordsökning har kommunernas arbete med att öka attraktiviteten för cykel som ett naturligt och självklart transportslag i stadsmiljö granskats utifrån ett normkritiskt perspektiv på transporter där bilen utgör det självkla

Background: Chronic suppurative otitis media (CSOM) is an important cause of hearing loss in children and constitutes a serious health problem globally with a strong association to resource-limited living conditions. Topical antibiotics combined with aural toilet is the first-hand treatment for CSOM but antimicrobial resistance and limited availability to antibiotics are obstacles in some areas. T