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Impact of temperature dependent sampling procedures in proteomics and peptidomics – A characterization of the liver and pancreas post mortem degradome

Little is known about the nature of post mortem degradation of proteins and peptides on a global level, the so-called degradome. This is especially true for non-neural tissues. Degradome properties in relation to sampling procedures on different tissues are of great importance for the studies of for instance post translational modifications and/or the establishment of clinical biobanks. Here, snap

Can the job content questionnaire be used to assess structural and organizational properties of the work environment?

Objective The theory behind the Job Content Questionnaire (JCQ) presumes that the "objective" social environment is measurable via self-report inventories such as the JCQ. Hence, it is expected that workers in identical work will respond highly similar. However, since no studies have evaluated this basic assumption, we decided to investigate whether workers performing highly similar work also resp

Kinks in the σ Band of Graphene Induced by Electron-Phonon Coupling

Angle-resolved photoemission spectroscopy reveals pronounced kinks in the dispersion of the sigma band of graphene. Such kinks are usually caused by the combination of a strong electron-boson interaction and the cutoff in the Fermi-Dirac distribution. They are therefore not expected for the sigma band of graphene that has a binding energy of more than approximate to 3.5 eV. We argue that the obser

Synthesis, Crystal Structure, and Bonding Analysis of the Hypoelectronic Cubic Phase Ca5Pd6Ge6.

The title compound, Ca5Pd6Ge6, was obtained during a systematic investigation of the Ca-Pd-Ge ternary phase diagram. The crystal structure was determined and refined from single-crystal X-ray diffraction data. It crystallizes in a new structure variant of the Y4PdGa12-type structure (Im3̅m, a = 8.7764(4) Å) that features an arrangement of vertex-sharing body-centered cubes of calcium, Ca@Ca8, with

Long term (13 years) prognosis after primary intracerebral haemorrhage: a prospective population based study of long term mortality, prognostic factors and causes of death.

INTRODUCTION: Many studies have focused on short term mortality after primary intracerebral haemorrhage (ICH) whereas long term prognosis and causes of death have been less studied. We therefore examined these issues in a population based cohort of 1 year ICH survivors. METHODS: ICH patients in a defined Swedish population (1.14 million inhabitants) were prospectively registered during 1996. Patie

Features of the Nyström method for the Sherman-Lauricella equation on Piecewise Smooth Contours

The stability of the Nyström method for the Sherman-Lauricella equation on contours with corner points $c_j$, $j=0,1,...,m$ relies on the invertibility of certain operators $A_{c_j}$ belonging to an algebra of Toeplitz operators. The operators $A_{c_j}$ do not depend on the shape of the contour, but on the opening angle $\theta_j$ of the corresponding corner $c_j$ and on parameters of the approxim

Degradation of neutrophil extracellular traps is decreased in patients with antiphospholipid syndrome.

A decreased ability to degrade neutrophil extracellular traps (NETs) is seen in a subgroup of patients with systemic lupus erythematosus (SLE) and correlates with the presence of autoantibodies. Antiphospholipid syndrome (APS) can develop secondary to SLE or as a primary disease. In the current study we investigated the ability of sera from patients with APS to degrade NETs. The presence of antibo

Dynamics of wave fluctuations in the homogeneous Yang-Mills condensate

In the present work, the Yang-Mills (YM) quantum-wave excitations of the classical homogeneous YM condensate have been studied in quasi-classical approximation. The formalism is initially formulated in the Hamilton gauge and is based upon canonical quantisation in the Heisenberg representation. This canonical framework is then extended and related to YM dynamics in arbitrary gauge and symmetry gro

Stability in the metamemory realism of eyewitness confidence judgments

The stability of eyewitness confidence judgments over time in regard to their reported memory and accuracy of these judgments is of interest in forensic contexts because witnesses are often interviewed many times. The present study investigated the stability of the confidence judgments of memory reports of a witnessed event and of the accuracy of these judgments over three occasions, each separate

Preoperative and perioperative use of levosimendan in cardiac surgery: European expert opinion.

In cardiac surgery, postoperative low cardiac output has been shown to correlate with increased rates of organ failure and mortality. Catecholamines have been the standard therapy for many years, although they carry substantial risk for adverse cardiac and systemic effects, and have been reported to be associated with increased mortality. On the other hand, the calcium sensitiser and potassium cha

Portraits of Call Centre Employees: Understanding control and identity work

This paper examines how employees respond to managements’ conflicting use of technocratic forms of control to ensure efficiency and socio-ideological control to produce an ‘on brand’ employee identity. The paper proposes a portrait-based form of ethnography as a way to illustrate both commonalities and differences in employees’ identity work and responses to managerial control within the call cent

Positive patch test reactions to oxidized limonene: exposure and relevance

Background. R-Limonene is a common fragrance terpene found in domestic and industrial products. R-Limonene autoxidizes on air exposure, and the oxidation products can cause contact allergy. In a recent multicentre study, 5.2% (range 2.3-12.1%) of 2900 patients showed a positive patch test reaction to oxidized R-limonene. Objective. To study the exposure to limonene among consecutive dermatitis pat

Generalised and Particularistic Thinking in Policy Analysis and Practice: The Case of Governance Reform in South Africa

This article is concerned with the relationship between generalised and particularistic knowledge in the context of policy-making and policy analysis. It argues that it is problematic to assume that a reform model will generate similar outcomes across a wide variety of contexts. It presents a conceptual framework, including the concepts of transaction domain and domain consensus, that enables cont

Statistical Modeling and Estimation of Censored Pathloss Data

Pathloss is typically modeled using a log-distance power law with a large-scale fading term that is log-normal. However, the received signal is affected by the dynamic range and noise floor of the measurement system used to sound the channel, which can cause measurement samples to be truncated or censored. If the information about the censored samples is not included in the estimation method, as i

Fracture Mechanics of Collagen Fibrils: Influence of Natural Cross-Links

Tendons are important load-bearing structures, which are frequently injured in both sports and work. Type I collagen fibrils are the primary components of tendons and carry most of the mechanical loads experienced by the tissue, however, knowledge of how load is transmitted between and within fibrils is limited. The presence of covalent enzymatic cross-links between collagen molecules is an import

Earwitnesses: the type of voice lineup affects the proportion of correct identifications and the realism in confidence judgments.

According to Tulving and Thomson (1973), similarity in encoding and recall contexts will facilitate recall. We investigated if similarity between the original voice event and the voice lineup helps people to identify the target from a voice lineup and helps improve the realism in participants' confidence judgments of the identification reports. Participants (n = 199) tried to identify a voice hear

Responsiveness of the OARSI-OMERACT osteoarthritis pain and function measures

Objective: To assess the responsiveness of the Intermittent and Constant Osteoarthritis Pain (ICOAP) measure, Hip Disability and Osteoarthritis Outcome Score Physical Function Short Form (HOOS-PS), and the Knee Disability and Osteoarthritis Outcome Score Physical Function Short Form (KOOS-PS) in a pharmacological trial. Methods: Data were obtained from a randomized double-blind trial comparing nap