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A multicentre study on the reliability of qualitative and quantitative nail-fold videocapillaroscopy assessment.

Objective. To investigate the inter- and intra-observer reliability of both qualitative and quantitative parameters used in the assessment of nail-fold capillaroscopy images.Methods. Fifty mosaic nail-fold images of healthy controls (n = 10), patients with primary RP (n = 10) and SSc (n = 30) were assessed in random order by two blinded observers on two occasions at centres in Sweden, UK and The N

To analyse measurements is to know!

Popular Abstract in Swedish Fjärrvärme är ett centraliserat uppvärmningssystem där varmt vatten distribueras i ett rörnätverk och används främst till byggnadsuppvärmning och för att värma varmvatten. Fjärrvärme finns i alla länder på norra halvklotet men har störst marknadsandel i Norden och Baltikum. I Sverige används fjärrvärme för att värma c:a 60% av all byggnadsyta. Två stora fördelar med fjäRenewable energy sources dominated the world energy supply until the beginning of the 20th century, when fossil energy became the dominant energy source worldwide. Today, fossil fuels contribute to over 80% of world energy supply. But there are two major reasons why fossil energy use has to stop. First, fossil energy is limited and will not last forever. Second, emissions of carbon dioxide change

The GLAST Satellite Calorimeter

The Gamma Ray Large Area Space Telescope (GLAST) is a multi-national satellite mission with aim to study the high-energy gamma ray sky. The main instrument is the Large Area Telescope (LAT) that consists of 16 towers, each housing a silicon strip precision tracker and a CsI(Tl) calorimeter. The calorimeter is made in a hodoscopic fashion from position sensitive crystal rods measuring 333.0 × 26.7

Cost-effectiveness of Screening for Abdominal Aortic Aneurysm in Combination with Medical Intervention in Patients with Small Aneurysms.

Screening for abdominal aortic aneurysm (AAA) among 65 year old men has been proven cost-effective, but nowadays is conducted partly under new conditions. The prevalence of AAA has decreased, and endovascular aneurysm repair (EVAR) has become the predominant surgical method for AAA repair in many centers. At the Malmö Vascular Center pharmacological secondary prevention with statins, antiplatelet

RIFM fragrance ingredient safety assessment, 2,6-Dimethyl-5-heptenal, CAS Registry Number 106-72-9.

The use of this material under current use conditions is supported by the existing information. This material was evaluated for genotoxicity, repeated dose toxicity, developmental toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity, skin sensitization potential, as well as environmental assessment. Repeated dose toxicity was determined to have the most conservative systemic

Deltas Apart - Factor Endowments, Colonial Extraction and Pathways of Agricultural Development in Vietnam

This study provides an explanation of the different pathways of agricultural change and economic development in north and south Vietnam. It shows that pre-colonial factor endowments conditioned the development of the rice economies of the two deltas in Tonkin and Cochinchina. The study relates to, and deviates from, the new literature on the colonial origins of contemporary development (Acemoglu,

Photodynamic therapy utilising topical delta-aminolevulinic acid in non-melanoma skin malignancies of the eyelid and the periocular skin

Purpose: Photodynamic therapy utilising delta-aminoleuvlinic acid-induced protoporphyrin IX photosensitisation, was evaluated as a treatment modality for nonmelanoma skin malignancies of the eyelids and the periocular skin, Methods: Photodynamic therapy with laser light at 635 nm was performed in 13 patients with 19 basal cell carcinomas and one patient with 3 cutaneous T-cell lymphoma lesions. A

AIB1 is a predictive factor for tamoxifen response in premenopausal women.

BACKGROUND: Clinical trials implicate the estrogen receptor (ER) coactivator amplified in breast cancer 1 (AIB1) to be a prognostic and a treatment-predictive factor, although results are not unanimous. We have further investigated this using a controlled randomised trial of tamoxifen versus control. Materials and methods: A total of 564 premenopausal women were entered into a randomised study ind

Cleavage of the Vesicular GABA Transporter under Excitotoxic Conditions Is Followed by Accumulation of the Truncated Transporter in Nonsynaptic Sites.

GABA is the major inhibitory neurotransmitter in the CNS and changes in GABAergic neurotransmission affect the overall activity of neuronal networks. The uptake of GABA into synaptic vesicles is mediated by the vesicular GABA transporter (VGAT), and changes in the expression of the transporter directly regulate neurotransmitter release. In this work we investigated the changes in VGAT protein leve

Chemorefractory rhabdomyosarcoma treated with radiotherapy, bevacizumab, statins and surgery and maintenance with bevacizumab and chemotherapy.

BACKGROUND: Rhabdomyosarcoma is a rare disease in children and young adults, usually responsive to chemotherapy. Here we report on a patient with chemorefractory disease, treated in an unconventional approach. CASE REPORT: A young woman presented with an embryonal rhabdomyosarcoma of the retromaxillary space. She exhibited progressive disease to two chemotherapy regimens. The patient started hyper

Interleukin-1beta up-regulates tumor necrosis factor receptors in the mouse airways.

Cytokines like interleukin-1beta (IL-1beta) and tumor necrosis factor alpha (TNFalpha), released during the inflammatory process, play important roles in the development of airway hyperresponsiveness. The effects of these cytokines are mediated by cell surface receptors, specific for each cytokine. The expression of cytokine receptors is a dynamic process, where receptors can be up- or down-regula