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Potential subtype-specific therapeutic approaches in small cell lung cancer

PURPOSE OF REVIEW: Small cell lung cancer (SCLC) remains one of the most aggressive thoracic malignancies with an especially dismal prognosis. While the detection of various targetable driver mutations and immune checkpoints have revolutionized the treatment of non-small cell lung cancer (NSCLC), there has been only modest therapeutic innovation over the past decades in SCLC. In this review, we ai

Slowly recurrent Collet–Eckmann maps with non-empty Fatou set

In this paper, we study rational Collet–Eckmann maps for which the Julia set is not the whole sphere and for which the critical points are recurrent at a slow rate. In families where the orders of the critical points are fixed, we prove that such maps are Lebesgue density points of hyperbolic maps. In particular, if all critical points are simple, these maps are Lebesgue density points of hyperbol

A Simple End-to-End Computer-Aided Detection Pipeline for Trained Deep Learning Models

Recently, there has been a significant rise in research and development focused on deep learning (DL) models within healthcare. This trend arises from the availability of extensive medical imaging data and notable advances in graphics processing unit (GPU) computational capabilities. Trained DL models show promise in supporting clinicians with tasks like image segmentation and classification. Howe

Injury patterns in Swedish elite female and male ice hockey – A cross-sectional comparison of past-season's injuries

Objectives: To describe and compare seasonal prevalence, anatomical location, severity, and onset of injuries between female and male elite ice hockey players. Design: Cross-sectional survey study. Setting: Elite ice hockey. Participants: Swedish elite ice hockey players (170 females & 190 males). Main outcome measures: Past season injuries reported on a modified version of the Oslo Sports Tra

Body mass index and weight gain in pregnancy and cardiovascular health in middle age : A cohort study

Objective: To examine associations between body mass index (BMI) in early pregnancy and gestational weight gain (GWG) with cardiovascular health in middle age using the ‘Life's Essential 8’ (LE8) concept of the American Heart Association (AHA). Design: Population-based cohort study. Setting: Swedish CardioPulmonary bioImage Study (SCAPIS). Population: A total of 8871 women from SCAPIS were include

Application of bipolar membrane electrodialysis for acidification of skim milk. A comprehensive study on process performance and effects on ion-exchange membranes

Bipolar membrane electrodialysis (EDBM) can be applied for the electro-acidification of skim milk (SM) using a water-splitting effect. A new method of SM acidification gives opportunities and perspectives to the development of alternative and novel products in the dairy industry. The present study assessed the effect of temperatures from 5 °C to 30 °C of EDBM on the electro-acidification of SM in

Collaboration and connectivity : Historical evidence from patent records

Why has collaboration become increasingly central to technological progress? We document the role of lowered travel costs by combining patent data with the rollout of the Swedish railroad network in the 19th and early-20th century. Inventors that gain access to the network are more likely to produce collaborative patents, which is partly driven by long-distance collaborations with other inventors

Impacts of landscape heterogeneity on bottom-up effects affecting biological control

Conservation biological control of crop pests by natural enemies relies on management strategies to favour their trophic interactions. In agricultural landscapes, natural enemies acting across habitat boundaries may feed on non-pest prey, resulting in apparent competition between non-pest prey and pests. Such communities, including pests, non-pest prey, and natural enemies have been shown to be af

Civil Society Elites : Exploring the Composition, Reproduction, Integration, and Contestation of Civil Society Actors at the Top

This open access book introduces a groundbreaking concept - civil society elites - and serves as an essential resource for scholars, researchers and students interested in the complexities of power and influence within contemporary civil societies. Through a series of unique empirical studies, the authors offer a comprehensive examination of the individuals occupying the upper echelons of influent

Cleric, Cadre, Businessman : China's Development Strategy in Sri Lanka

Join us in exploring China's fascinating use of religion in foreign policy and its vital role in China's soft power strategy. Tabita Rosendal Ebbesen unravels Chinese Development policy, governance practices and the use of Buddhism in diplomatic and public diplomacy efforts in Sri Lanka in conversation with Frode Hübbe.Mentioned in the article is Tabita’s great article China’s Buddhist Strategic N

Effects of breathing variables on modelled particle lung deposition at physical activity for children and adults

The respiratory tract deposited fraction (DF) is the link between exposure and health effects of airborne particles. Here, we investigate how breathing pattern alterations at increasing physical activity affect DF in different regions of the respiratory tract and compare DF between adults and children (5 and 10 years old). We performed a literature review on the alteration of tidal volume with min

Constructing type-II CuInSe2/CuInS2 core/shell quantum dots for high-performance photoelectrochemical cells

CuInSe2 (CISe) quantum dots (QDs) have shown promising applications in photoelectrochemical (PEC) cells due to their nontoxicity, high extinction coefficient, and wide optical absorption range; however, their low PEC performance prevents their applications due to insufficient charge carrier separation and severe charge recombination. Herein, CISe/CuInS2 (CISe/CIS) core/shell structured QDs are des

Bees, Wasps, and Weasels : Zoomorphic Slurs and the Delegitimation of Deborah and Huldah in the Babylonian Talmud

In this book, Blaženka Scheuer explores the zoomorphic content of Zibburta (bee/wasp) and Karkušta (weasel)—demeaning names given by R. Naḥman of b. Meg 14b to Deborah and Huldah, two distinguished prophets of the Hebrew Bible. Looking closely at relevant texts, she explores ancient beliefs about bees, wasps, and weasels, recounting a variety of key literary and visual motifs that highlight the di

The Rape of the Lock : Or a Comparison between Miniature Images of the Eighth and Eighteenth Centuries

This paper discusses Scandinavian gold foil igures from the early part ofthe Scandinavian Late Iron Age (AD 550-1050) as well as miniature portrait pendants of the eighteenth century. he paper examines the possibility of comparing the two categories of objects, and what may be gained by contrasting historic and prehistoric images. he comparison is made through using Mitchell’s concept meta-picture

Imagery beyond representation

Pictorial and visual elements are special types of archaeological data that transgress boundaries: between us and the past and between the material and immaterial. Traditionally, images have been discussed in terms of what they represent, mean or symbolize. In this volume, the authors explore other ways in which images a!ect and engage the beholder and the modes in which they are entangled in past