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Declining bond yields and rising public debts have caused many economists to suggest raising the debt ceiling in the EU’s Stability and Growth Pact. Implicitly, they argue for replacing GDP as the anchor with the bond yield. We discuss the risks of such a shift. While such a change would provide shortterm relief to highly indebted EU member states, it is based on the expectation that bond yields wDeclining bond yields and rising public debts have caused many economists to suggest raising the debt ceiling in the EU’s Stability and Growth Pact. Implicitly, they argue for replacing GDP as the anchor with the bond yield. We discuss the risks of such a shift. While such a change would provide short-term relief to highly indebted EU member states, it is based on the expectation that bond yields

Arrangements for collaboration in knowledge production across academia, government, non-governmental organisations, and corporations have several names, such as citizen-science, community-based participatory research, engaged research and hybrid forums. The multiplicity of schemes does not lie only in the high number of names for various versions of collaborative knowledge production. Different sc

X-ray microscopy is an essential imaging method in many scientific fields, which can be extended to three-dimensional (3D) using tomography. Recently, metal halide perovskite (MHP) nanomaterials have become a promising candidate for X-ray scintillators, due to their high light yield, high spatial resolution, and easy fabrication. Tomography requires many projections and therefore scintillators wit

Objective While the incidence of children suffering from autoimmune type 1 diabetes (T1D) is increasing in Sweden and worldwide, the underlying etiology and cellular mechanisms behind this remain unknown. The predisposition of the high-risk HLA DR-DQ genotype and as yet unknown environmental triggers lead to autoimmunity and the onset of T1D, which is preceded by islet beta-cell autoantibodies a

Objective. The objective of this study was to explore whether recombinant GAD65 conjugated hydroxide (GAD-alum) treatment affected peripheral blood T-cell subpopulations in healthy children with multiple beta cell autoantibodies. Method. The Diabetes Prevention–Immune Tolerance 2 (DiAPREV-IT 2) clinical trial enrolled 26 children between 4 and 13 years of age, positive for glutamic acid decarboxyl

Purpose: The optimal ventilatory settings in patients after cardiac arrest and their association with outcome remain unclear. The aim of this study was to describe the ventilatory settings applied in the first 72 h of mechanical ventilation in patients after out-of-hospital cardiac arrest and their association with 6-month outcomes. Methods: Preplanned sub-analysis of the Target Temperature Manage

Iridium pincer complexes of the type (POCOP)Ir (POCOP = 2,6-(tBu2PO)2C6H3) are very productive catalysts for dehydrogenation of secondary alcohols. To our surprise, we found that turnover frequencies demonstrated by (POCOP)IrH2 (IrH2) are higher in more dilute solutions of the catalyst, which triggered a mechanistic study of alcohol dehydrogenation by IrH2. Here, we provide strong evidence that ac

The present disclosure relates to compositions for reprogramming cells into conventional dendritic cells (cDC), particularly into cDC type 2 (hereinafter referred to as “cDC2” or “CD11b-positive dendritic cells”), methods and uses thereof. The present disclosure relates to the development of methods for making conventional dendritic cells with antigen presenting capacity from differentiated, multi

The present disclosure relates to compositions, constructs and vectors for reprogramming cells into plasmacytoid dendritic cells or interferon type I-producing cells, methods and uses thereof. The present disclosure relates to the development of methods for making plasmacytoid dendritic cells or interferon type I-producing cells that promote antiviral and anti-tumoral immune responses from differe

The present disclosure relates to compositions, nucleic acid constructs, methods and kits thereof for cell induction or reprogramming cells to the dendritic cell state or antigen presenting cell state, based, in part, on the surprisingly effect described herein of novel use and combinations of transcription factors that permit induction or reprogramming of differentiated or undifferentiated cells

We assemble the Irish industrial data currently available for the years 1800-1921, the period during which the entire island was in a political Union with Great Britain, and construct an annual index of Irish industrial output for 1800-1913. We also construct a new industrial price index. Irish industrial output grew by an average of 1.3 per cent per annum between 1800 and the outbreak of the Firs

The disclosure relates to the development of methods for making hematopoietic stem cells from differentiated cells by introducing and expressing transcription factors. More particularly, the disclosure provides methods for redirecting differentiated cells to a hematopoietic stem cell state or to a hemogenic endothelial cell state by direct programming with specific combinations of transcription fa

In the philosophy of J. L. Schellenberg, “evolutionary religion” is a religious stance oriented towards the deep future. According to Schellenberg, the best form of evolutionary religion is non-doxastic faith in ultimism. I reject Schellenberg’s arguments for preferring ultimism and suggest that committing non-doxastically to traditional religion makes more sense from an evolutionary perspective.