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The National Spinal Cord Injury Registry of Iran (NSCIR-IR) is a not-for-profit, hospital-based, and prospective observational registry that appraises the quality of care, long-term outcomes and the personal and psychological burden of traumatic spinal cord injury in Iran. Benchmarking validity in every registry includes rigorous attention to data quality. New publication in Chinese Journal of Tra

https://www.lupop.lu.se/article/national-spinal-cord-injury-registry-iran-nscir-ir-critical-appraisal-its-strengths-and-weaknesses - 2025-10-15

Vascunet has previously published an international comparison of registry data within vascular surgery. Data validity and completeness in participating registries is essential for a meaningful interpretation of differences between countries. The Vascunet collaboration has therefore developed a methodology for validation of international vascular registry data, previously used for validation of two

https://www.lupop.lu.se/article/international-validation-danish-vascular-registry-karbase-vascunet-report - 2025-10-15

The use of clinical autopsy has been in decline for many years throughout healthcare systems of developed countries despite studies showing substantial discrepancies between autopsy results and pre-mortal clinical diagnoses. We conducted a study to evaluate over time the use and results of clinical autopsies in Sweden. We reviewed the autopsy reports and autopsy referrals of 2410 adult (age > 17)

https://www.lupop.lu.se/article/cause-death-and-significant-disease-found-autopsy - 2025-10-15

Inflammatory bowel disease (IBD) is a chronic, inflammatory relapsing disease with increasing incidence. IBD research and long-term follow-up of patients have, however, been hampered by lack of detailed data on disease phenotype, patient-reported outcome measures, Physician Global Assessment, disease activity, and hospital-administered drugs. New publication in Scandinavian Journal of Gastroentero

https://www.lupop.lu.se/article/swedish-inflammatory-bowel-disease-register-swibreg-nationwide-quality-register - 2025-10-15

The World Cancer Research Fund International has concluded strong evidence for that high intake of dairy products and foods containing dietary fiber and low intake of processed meat are associated with decreased risk of colorectal cancer (CRC). As food items are consumed together, it is important to study dietary patterns. New publication in European Journal of Cancer Prevention

https://www.lupop.lu.se/article/colorectal-cancer-diet-quality-index-inversely-associated-colorectal-cancer-malmo-diet-and-cancer - 2025-10-15

Orphan drugs are medicines intended to treat, prevent, or diagnose a rare and serious condition. The collection of pre-marketing safety and efficacy data for orphan drugs is very challenging for several reasons related to the rarity of the diseases. This highlights the need for robust post-marketing evidence generation. Real-world data sources, such as claims databases, electronic healthcare recor

https://www.lupop.lu.se/article/role-healthcare-databases-and-registries-surveillance-orphan-drugs-real-world-setting-italian-case - 2025-10-15

Patient registries are routinely used in dermatology and psoriasis registries offer pertinent long-term safety information regarding conventional systemic therapies and biologic agents for psoriasis. New publication in Journal of Dermatological Treatment

https://www.lupop.lu.se/article/review-european-registries-psoriasis - 2025-10-15

Oestrogen receptor-positive (ER+) and human epidermal receptor 2-negative (HER2–) breast cancers are classified as Luminal A or B based on gene expression, but immunohistochemical markers are used for surrogate subtyping. The aims of this study were to examine the agreement between molecular subtyping (MS) and surrogate subtyping and to identify subgroups consisting mainly of Luminal A or B tumour

https://www.lupop.lu.se/article/agreement-between-molecular-subtyping-and-surrogate-subtype-classification-contemporary-population - 2025-10-15

Patient registries, ‘organised systems that use observational methods to collect uniform data on a population defined by a particular disease, condition, or exposure, and that is followed over time’, are potentially valuable sources of data for supporting regulatory decision-making, especially for products to treat rare diseases. Nevertheless, patient registries are greatly underused in regulatory

https://www.lupop.lu.se/article/patient-registries-underused-resource-medicines-evaluation - 2025-10-15

To assess the impact on exposure time and outcome misclassifications, and consequent impact on exposure-outcome associations from treatment episode construction. We investigated the dosage assumptions of 1 unit per day, and 1 DDD per day, versus actual prescribed dosage under different handling of gaps and overlaps of prescriptions. New publication in European Journal of Clinical Pharmacology

https://www.lupop.lu.se/article/methods-constructing-treatment-episodes-and-impact-exposure-outcome-associations - 2025-10-15

The aim of this study was to examine whether the self‐reported use of analgesics is associated with being a victim of bullying. New publication in Acta Paediatrica

https://www.lupop.lu.se/article/bullying-pain-and-analgesic-use-school-age-children - 2025-10-15

Sibling comparison designs have long been used to assess causal effects of exposures for which randomized studies are impossible and measurement of all relevant confounding is unobtainable. The idea is to utilize the fact that siblings often share a lot of unobserved variables. Therefore, it is proposed that in certain cases, comparing siblings is equivalent to comparing exchangeable individuals,

https://www.lupop.lu.se/article/what-causal-interpretation-sibling-comparison-designs - 2025-10-15

A central element of assimilation theory is that increasing time and number of previous immigrant generations in a host country leaves immigrants and their children more integrated and capable of navigating the host society. However, the underperformance of some immigrant groups in Sweden calls into question this relationship. Additionally, many studies regard intermarriage as an outcome of immigr

https://www.lupop.lu.se/article/time-and-generation-parents-integration-and-childrens-school-performance-sweden-1989-2011 - 2025-10-15

The Swedish Twin Registry functions as research infrastructure containing information on 216,258 twins born between 1886 and 2015, of whom 86,199 pairs have zygosity determined by DNA, an intrapair similarity algorithm, or being of opposite sex. In essence, practically all twins alive and currently 9 years or older have been invited for participation and donation of DNA on which genomewide single

https://www.lupop.lu.se/article/swedish-twin-registry-content-and-management-research-infrastructure - 2025-10-15

Periodontal disease is associated with cardiovascular disease (CVD) but it is unknown if periodontal disease severity is associated with asymptomatic carotid plaque. The aim of the current population‐based, observational study was to investigate if signs of periodontal disease are associated with the occurrence of carotid plaque and total plaque area (TPA). New publication in Journal of Internal M

https://www.lupop.lu.se/article/periodontal-disease-associated-carotid-plaque-area-malmo-offspring-dental-study-mods - 2025-10-15

Implications of study findings include underreporting, prescribing and outcome misclassification, and reduced generalizability to population risk groups, information of importance to epidemiologists and researchers using PDMP data. New publication in Epidemiology

https://www.lupop.lu.se/article/record-linkage-approaches-using-prescription-drug-monitoring-program-and-mortality-data-public - 2025-10-15

To compare the risk and severity of prostate cancer between men achieving fatherhood by assisted reproduction and men conceiving naturally. New publication in the bmj

https://www.lupop.lu.se/article/risk-prostate-cancer-men-fathering-through-assisted-reproduction-nationwide-population-based-0 - 2025-10-15

Psychiatric re-hospitalisation rates have been of longstanding interest as health care quality metric for planners and policy makers, but are criticized for not being comparable across hospitals and countries due to measurement unclarities. The objectives of the present study were to explore the interoperability of national electronic routine health care registries of six European countries (Austr

https://www.lupop.lu.se/article/using-national-electronic-health-care-registries-comparing-risk-psychiatric-re-hospitalisation-six - 2025-10-15

The purpose of this study was to report on the prevalence and incidence of mild cognitive impairment (MCI) across age, sex, and subtypes according to various criteria in a population-based sample. New publication in Dementia and Geriatric Cognitive Disorders

https://www.lupop.lu.se/article/prevalence-and-incidence-mild-cognitive-impairment-across-subtypes-age-and-sex - 2025-10-15

Although the registers in this collaboration have similar designs, we found numerous differences in the variables collected. This survey of the status quo of current pregnancy registers is the first step towards identifying data collected uniformly across registers in order to facilitate joint analyses. New publication in Arthritis Research & Theraphy

https://www.lupop.lu.se/article/european-network-pregnancy-registers-rheumatology-eunep-overview-procedures-and-data-collection - 2025-10-15