In the post-genomic era, it has become evident that genetic changes alone are not sufficient to understand most disease processes including pancreatic cancer. Genome sequencing has revealed a complex set of genetic alterations in pancreatic cancer such as point mutations, chromosomal losses, gene amplifications and telomere shortening that drive cancerous growth through specific signaling pathways

The modernisation of Swedish households during the twentieth century prompted a considerable productivity growth in household production. This paper examines the association between this process and the allocation of female time in Swedish urban households during the period 1920-1990. Estimates presented in the paper suggest a minimum potential time reduction for a fixed volume of routine househol

A search is presented for narrow diboson resonances decaying to [Formula: see text] or [Formula: see text] in the final state where one [Formula: see text] boson decays leptonically (to an electron or a muon plus a neutrino) and the other [Formula: see text] boson decays hadronically. The analysis is performed using an integrated luminosity of 20.3 fb[Formula: see text] of [Formula: see text] coll

A search for first generation scalar and vector leptoquarks produced in ep collisions is performed by the H1 experiment at HERA. The full H1 data sample is used in the analysis, corresponding to an integrated luminosity of 446 pb(-1). No evidence for the production of leptoquarks is observed in final states with a large transverse momentum electron or with large missing transverse momentum, and co

Purpose – The two-fold purpose of this paper is identifying areas of difficulty in managing the needs of end-users in the course of the design and delivery of construction projects and suggesting possible solutions. Design/methodology/approach – The focus of the paper is the interaction between three principal parties: end-users, project leader (a selected end-user) and facility planner (a facil

In electromyographic (EMG) and functional magnetic resonance imaging (fMRI) studies, muscle and brain activity was compared during low levels of tooth clenching using a novel biting device to control bite force. A total of 21 healthy subjects performed motor tasks, comprising tooth clenching at 5, 10 and 20N. During all measurements, subjects kept the novel bite device between the anterior teeth d

Nitric oxide (NO) was described to inhibit the proliferation of neural stem cells. Some evidence suggests that NO, under certain conditions, can also promote cell proliferation, although the mechanisms responsible for a potential proliferative effect of NO in neural stem cells have remained unaddressed. In this work, we investigated and characterized the proliferative effect of NO in cell cultures

This case study investigates the role of social-psychological variables in the general public's intention to support conservation of five local biotopes. A questionnaire survey of 245 people was carried out in Kristianstad Municipality, Sweden. In hierarchical regression analyses, public intention to support conservation was partly predicted by attitude toward biodiversity conservation and by pers

Background: Epidemiologic data and animal models suggest that, despite the predominant role of human papillomavirus infection, sex steroid hormones are also involved in the etiology of invasive cervical carcinoma (ICC). Methods: Ninety-nine ICC cases, 121 cervical intraepithelial neoplasia grade 3 (CIN3) cases and 2 control women matched with each case for center, age, menopausal status and blood

Background. For Diffuse large B-cell lymphoma (DLBCL), the International Prognostic Index is the major tool for prognostication and considers an age above 60 years as a risk factor. However, there are several indications that increasing age is associated with more biological complexity, resulting in differences in DLBCL biology depending on age. Methods. We conducted a registry-based retrospective

BACKGROUND: Treatment of idiopathic membranous nephropathy with nephrotic syndrome is still controversial. There is currently little known about the clinical use of renal biomarkers which may explain contradictory results obtained from clinical trials. In order to assess whether IgG-uria can predict the outcome in membranous nephropathy, we examined the value of baseline EF-IgG in predicting remis

The visual behaviour of consumers buying (or searching for) products in a supermarket was measured and used to analyse the stages of their decision process. Traditionally metrics used to trace decision-making processes are difficult to use in natural environments that often contain many options and unstructured information. Unlike previous attempts in this direction (i.e. Russo & Leclerc, 1994

This paper is the fourth in a series discussing experiences in applying the Strategic Systemic Thinking (SST) framework. The framework was originally proposed for the purpose of supporting contextual analysis into complex problem spaces as part of information systems analysis. Previous papers have dealt with an application supporting strategic development of work in an academic university departme

Diabetes is increasing worldwide and hence the risk developing complications where retinopathy is the theme of this study. The aim of the study was to evaluate the presence of (vascular) retinopathy in subjects with the pre-diabetes stage, impaired fasting glucose (IFG), and the development of retinopathy in these subjects during five years. In the second part of the study diabetes patients with d

Background: Enhancement of enzymatic digestibility by some supplementations could reduce enzyme loading and cost, which is still too high to realize economical production of lignocellulosic biofuels. A recent study indicates that yeast hydrolysates (YH) have improved the efficiency of cellulases on digestibility of furfural residues (FR). In the current work, the components of YH were separated by