Mutations that cause X-linked agammaglobulinemia (XLA) appear throughout the Bruton tyrosine kinase (Btk) sequence, including the pleckstrin homology (PH) domain. To analyze the basis of this disease with respect to protein structure, we studied the relationships between PH domain sequences and structures by comparing sequence-based profiles of physicochemical properties and solvent accessibility

Popular Abstract in Swedish Förmaksflimmer är den vanligaste rytmrubbningen i hjärtat som kräver behandling. Risken att drabbas ökar med åldern och 8% av alla åttioåringar lider av förmaksflimmer. Förmaksflimmer är i sig inte livshotande, men den förhöjda risken för proppbildning i förmaken kan leda till allvarliga komplikationer såsom stroke. Det finns olika behandlingsstrategier för förmaksflimmThis thesis deals with signal processing algorithms for analysis of the electrocardiogram (ECG) during atrial fibrillation (AF). Such analysis can be used for diagnosing patients, and for monitoring and predicting their response to various treatment. The thesis comprises an introduction and five papers describing methods for ECG-based modeling and characterization of AF. Paper I--IV deal with meth

Purpose: Biokinetic and dosimetry studies in laboratory animals often precede clinical radionuclide therapies in humans. A reliable evaluation of therapeutic efficacy is essential and should be based on accurate dosimetry data from a realistic dosimetry model. The aim of this study was to develop an anatomically realistic dosimetry model for Brown Norway rats to calculate S factors for use in eva

This article aims to contribute to the critical examination of the notions of health and activity, and to discuss how these cultural and social constructs have impact on elderly people’s lives. An ethnographic perspective gives fruitful inputs to explore how old people deal with the image of old age as one of decay and decline, while they simultaneously relate to the normative idea of so-called su

The murine chemokine receptor 2 (mCXCR2) controls resistance to urinary tract infection. We have previously shown that mCXCR2 knockout mice develop severe acute pyelonephritis and renal tissue damage with sub-epithelial neutrophil entrapment. In this study we examined the relative importance of neutrophil- and epithelial-specific mCXCR2 expression for bacterial clearance in bone marrow chimeric mi

AIMS/HYPOTHESIS: This study aimed to examine hand disorders, symptoms, overall hand function, activities of daily living (ADLs), and life satisfaction in elderly men with type 2 diabetes mellitus (DM), impaired glucose tolerance (IGT), and normal glucose tolerance (NGT). METHODS: Subjects were interviewed and evaluated with a battery of clinical and laboratory tests, including hand assessment, and

In this paper I argue that Small pro is not needed as a representative for null subjects in languages like Italian, Spanish, Standard Arabian etc. Instead I propose the Person Phrase hypothesis, which claims that agreement originates as the head of the subject argument. this argument is analyzed as PersP, seen as an expanded DP, [PersP Agr DP]. Agr is a bound morpheme, and thus cannot survive with

The reasons for loss of credibility are first scientism and evasion, which feed oversimplification and confusion as the primary reasons. A case study from central Sudan is used to illustrate of these issues. Credibility has drained away with the deflection of focus from matters that are patently “ desertification” ; and with the deployment of confusing science. The choice to emphasize land degrada

Choline acetyltransferase (ChAT) is the key-enzyme for acetylcholine (ACh) synthesis and constitutes a reliable marker for the integrity of cholinergic neurons. Cortical ChAT activity is decreased in the brain of patients suffering from Alzheimer's and Parkinson's diseases. The standard method used to measure the activity of ChAT enzyme relies on a very sensitive radiometric assay but can only be

Adolescents with immigrant or ethnic minority background suffering from asthma receive on average less appropriate anti-asthmatic medication (AAM) than the majority population. However, those findings are based on analyses of differences between group averages which prevents our understanding of individual heterogeneity around the averages. Taking into account individual socioeconomic factors and

Popular Abstract in Swedish Potatis är ett av våra viktigaste baslivsmedel, men erbjuder trots det stor variation. Traditionella recept varvas med nya innovationer i hushåll och restauranger, och inom livsmedelsindustrin processas potatisen till en rad olika produkter. Från traditionell kokt potatis med sås inom husmanskosten har våra matvanor förändrats radikalt. Ökade krav på snabb och enkel tilThe potato is one of our most important food crops, being sold in its natural state or processed into a wide range of products. Starch, by far the most abundant component in the tuber, is greatly affected by heat processing. Therefore it is logical to study starch thermal properties within the tuber tissue, although most previous studies have focused on starch-water model systems. One of the main

Popular Abstract in Swedish I avhandlingen studeras plasminogenaktiverings-systemets (PA-systemets) komponenter i livmoderslemhinnan. PA-systemet reglerar omvandlingen av plasminogen till plasmin. Plasminogen är ett inaktivt enzym som finns överallt i kroppsvätskor samt i kroppens olika organ. Aktiveringen katalyseras av aktivatorer, antingen urokinase plasminogen activator (uPA) eller tissue plasThe release of urokinase plasminogen activator (uPA) from endometrial stromal cells decreased after progesterone stimulation, due to upregulation of PA inhibitor 1 (PAI-1) and uPA receptor (uPAR). Subsequently, the uPA:PAI-1 complex was internalized and degraded via uPAR. Predecidual cells in the late secretory phase expressed PAI-1 and uPAR, supporting a specific role for predecidual cells in the