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TNF-alpha-induced self expression in human lung endothelial cells is inhibited by native and oxidized alpha 1-antitrypsin

Endothelial cells are among the main physiological targets of the pro-inflammatory cytokine tumor necrosis factor-alpha (TNF-alpha). In endothelial cells TNF-alpha elicits a broad spectrum of biological effects including differentiation, proliferation and apoptosis. alpha 1-antitrypsin (AAT), an endogenous inhibitor of serine proteases plays a vital role in protecting host tissue from proteolytic

How to form planetesimals from mm-sized chondrules and chondrule aggregates

The size distribution of asteroids and Kuiper belt objects in the solar system is difficult to reconcile with a bottom-up formation scenario due to the observed scarcity of objects smaller than similar to 100 km in size. Instead, planetesimals appear to form top-down, with large 100 1000 km bodies forming from the rapid gravitational collapse of dense clumps of small solid particles. In this paper

Skandinavien och första världskriget

The centenary of the outbreak of the First World War in 1914 has spurred a lively popular and academic debate about the conflict's role in shaping the twentieth century and the European present. This article examines the war from a slightly different perspective, taking as its point of departure the impact of the war on neutral Scandinavia and its place in contemporary Scandinavian historical cons

Models and Methodology for Optimal Vehicle Maneuvers Applied to a Hairpin Turn

There is currently a strongly growing interest in obtaining optimal control solutions for vehicle maneuvers, both in order to understand optimal vehicle behavior and to devise improved safety systems, either by direct deployment of the solutions or by including mimicked driving techniques of professional drivers. However, it is nontrivial to find the right mix of models, formulations, and optimiza

"This is what we did last time". Uncertainty over landscape analysis and its procurement in the Swedish road planning process

In some European countries, landscape analysis has long been used in support of large-scale planning or major projects such as new trunk roads and mainline rail routes, in line with both the UN's Convention on Environmental Impact Assessment and the European Landscape Convention. Some countries, however, lack a regulatory framework for what should be analysed, how a landscape analysis should be co

The Price of Responsibility: Ethics of Animal Husbandry in a Time of Climate Change

This paper examines the challenges that climate change raises for animal agriculture and discusses the contributions that may come from a virtue ethics based approach. Two scenarios of the future role of animals in farming are set forth and discussed in terms of their ethical implications. The paper argues that when trying to tackle both climate and animal welfare issues in farming, proposals that

The influence of micro-chacracteristics and the region in different modes of globalization of innovation A comparative study of Pune region and Beijing region

Since the seminal work of Archibugi and Michie (1995) on the globalization of innovation, several authors have attempted to understand the complex relationship between innovation and internationalization. However, most tend to focus on industrialized countries, just one mode of globalization of innovation and often one traditional indicator of innovation, such as patents or R&D investment, thu

Tuning the oxidation degree in sub-10 nm silver-oxide nanoparticles: From Ag2O monoxide to AgOx(x > 1) superoxide

A preparation method for silver-oxide containing nanoparticles is described. The suggested approach allows varying the oxidation degree from monoxide to an oxygen-rich state resembling superoxide The method is based on magnetron reactive sputtering and vapour aggregation, and utilizes silver-oxygen interaction in the vapour phase - prior to the nanoparticle aggregation from the vapour. Synchrotron

Onset of color decoherence for soft gluon radiation in a medium

We report on recent studies of the phenomenon of color decoherence in jets in QCD media. The effect is most clearly observed in the radiation pattern of a quark-antiquark antenna, created in the same quantum state, traversing a dense color deconfined plasma. Multiple scattering with the medium color charges gradually destroys the coherence of the antenna. In the limit of opaque media, this ultimat

Röde Orms många liv

Artikel om mottagandet av Röde Orm från 1940-talet till våra dagar samt en analys av romanens mediering, det vill säga de nya gestaltningar som den fått i form av till exempel spelfilm och tecknad serie.

The MAXIII storage ring

One of the primary goals of the 700MeV MAX III synchrotron radiation source is to test and gain experience with new magnet and accelerator technology. Each magnet cell is machined out of two solid iron blocks that are then sandwiched together after coil and quadrupole installation. The MAX III ring makes extensive use of combined function magnets to obtain a compact lattice. In order to obtain fle

Effect of pressure, temperature, fluorine doping, and rare earth elements on the phonon density of states of LFeAsO studied by nuclear inelastic scattering

We have performed systematic studies of the lattice dynamics in LFeAsO (L = La, Ce, Pr, Nd, Sm) in the parent and in the similar to 10% F-doped compounds as a function of pressure and temperature. We have found that the modifications in the partial Fe density of phonon states are mainly governed by the Fe-As bond length. The change of this bond length explains the change of the Fe density of phono

Environmental variation in ecological communities and inferences from single-species data

Data are often collected for a single species within an ecological community, so quantitative tools for drawing inferences about the unobserved portions of the community from single-species data are valuable. In this paper, we present and examine a method for estimating community dimension (the number of strongly interacting species or groups) from time series data on a single species. The dynamic

The comparison of particle oxidation and surface structure of diesel soot particles between fossil fuel and novel renewable diesel fuel

Conventional fossil diesel fuel and renewable diesel fuel based on hydrotreated vegetable oils (HVO) were compared regarding the oxidation characteristics of the generated soot particulate. The comparison was performed by utilizing a high-temperature oxidation tandem differential mobility analyser in which monodisperse soot aerosol was first selected and then heated in a high-temperature furnace.