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Kronisk myeloisk leukemi : Förebild för målstyrd terapi

Vid kronisk myeloisk leukemi har målstyrd, kontinuerlig behandling med tyro­sinkinashämmare lett till dramatiskt förbättrad överlevnad.Chronic myeloid leukemia (CML) pioneered as the first human malignancy linked to a specific cytogenetic aberration (the Philadelphia chromosome), which led the way to specific targeted therapies with imatinib (Glivec) and later tyrosine kinase inhibitors (TKI). Continuous TKI administration, blocking the oncogenic fusion protein Bcr-Abl, has revolutionized the outcome of CML, transforming an almos

Neighbourhood deprivation and risk of morbidity and mortality in people with lung cancer: A multilevel analysis from Sweden

Objectives: To analyze whether there is an association between neighbourhood deprivation and morbidity and mortality of lung cancer, beyond individual level characteristics. Design: The entire Swedish population aged over 50, a total of 3.2 million individuals, was followed from January 1, 2000, until admission due to morbidity or mortality of lung cancer during the study period, or the end of the

Emotion regulation group therapy for deliberate self-harm : A multi-site evaluation in routine care using an uncontrolled open trial design

Objective Emotion regulation group therapy (ERGT) has shown promising results in several efficacy trials. However, it has not been evaluated outside a research setting. In order to increase the availability of empirically supported treatments for individuals with borderline personality disorder and deliberate self-harm, an evaluation of ERGT in routine clinical care was conducted with therapists o

When children undergo radiotherapy. Exploring care, developing and testing preparation procedures

Radiotherapy (RT) is a repetitive treatment divided into daily fractions, scheduled five days a week from one up to several weeks depending upon the child’s diagnosis. Although RT is painless and non-invasive, children experience anxiety. Depending on the child’s age, anxiety or inability to comply, they may require sedation or general anaesthesia (GA), meaning that some children receive GA over 3

Wireline Communications in a Wireless World

The whole society is digitalizing, filled with streaming services, cloud computing and an ambition of ubiquitous connectivity. To address the data demand, ultra-fast broadband, at the speeds of 1Gbps and more, is developed and deployed. Optical fibers have been long viewed as a future-proof carrier for the ultra-fast broadband. However, the physical deployment of fiber networks, including digging,

Prescription of potentially inappropriate medications among older people with intellectual disability: a register study

BACKGROUND: Older people have a greater disease burden and are more likely than younger to be prescribed medications. They are also more sensitive to adverse effects. With this in mind, a range of medications have been suggested inappropriate in this population. People with intellectual disability (ID) have a higher disease burden than the general population, putting them at even greater risk of p