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Effects of 24-h and 36-h Sleep Deprivation on Human Postural Control and Adaptation.

This study investigated whether human postural stability and adaptation were affected by sleep deprivation and the relationship between motor performance and subjective scores of sleepiness (visuo-anlogue sleepiness scores, VAS). Postural stability and subjective sleepiness were examined in 18 healthy subjects (mean age 23.8 years) following 24 and 36 h of continued wakefulness, ensured by portabl

Co-adsorption of cadmium(II) and glyphosate at the water-manganite (gamma-MnOOH) interface

The co-adsorption of Cd(II) and glyphosate (N-(phosphonomethyl)glycine, PMG) at the manganite (gamma-MnOOH) surface has been studied in the pH range 6-10 at 25 degrees C and with 0.1 M Na(Cl) as ionic medium. Batch adsorption experiments, Fourier transform infrared spectroscopy (FTIR), X-ray photoelectron spectroscopy (XPS) and extended X-ray absorption fine Structure (EXAFS) spectroscopy were use

IdeS and SpeB: immunoglobulin-degrading cysteine proteinases of Streptococcus pyogenes.

The Gram-positive bacterium Streptococcus pyogenes is a major human pathogen causing substantial morbidity and mortality in society. S. pyogenes has evolved numerous molecular mechanisms to avoid the various actions of the human immune system and has established means to modulate both adaptive and innate immune responses. S. pyogenes produces and secretes proteolytic enzymes, which have an importa

Phase behavior and protein partitioning in aqueous two-phase systems of cationic-anionic surfactant mixtures

Cationic-anionic surfactant mixtures can form aqueous two-phase systems. Such aqueous surfactant two-phase systems (ASTP systems) can be used for separation and purification of biomaterials. In this work we investigated the phase behavior and the partitioning of BSA and lysozyme in the ASTP system formed by mixtures of dodecyltriethylammonium bromide and sodium dodecylsulfate (SDS). The pseudo ter

The collaborative learning methodology CORONET-Train: Implementation and guidance

The introduction of new methodologies into a software organization is a non-trivial problem because it usually requires the alteration of existing business and development processes and the change of habits and beliefs of software engineers and managers. This is particularly true for comprehensive methodologies that integrate e-learning and knowledge management. An example is the web-based collabo

Is there screwiness at the end of the QCD cascades?

We discuss what happens at the end of the QCD cascades. We show that, with just a few reasonable assumptions, the emission of soft gluons is constrained to produce an ordered field in the form of a helix. We describe how to modify the Lund fragmentation scheme in order to fragment such a field. Our modified fragmentation scheme yields results which are consistent with current experimental measurem

Comprehensive evaluation of the genetic variants of interferon regulatory factor 5 (IRF5) reveals a novel 5 bp length polymorphism as strong risk factor for systemic lupus erythematosus

We analyzed a comprehensive set of single-nucleotide polymorphisms (SNPs) and length polymorphisms in the interferon regulatory factor 5 (IRF5) gene for their association with the autoimmune disease systemic lupus erythematosus (SLE) in 485 Swedish patients and 563 controls. We found 16 SNPs and two length polymorphisms that display association with SLE (P < 0.0005, OR > 1.4). Using a Bayesian mod

Subnormal operators with compact selfcommutator

If $S$ is a hyponormal operator, then Putnam's inequality gives an estimate on the norm of the self-commutator $[S^*,S]$, while the Berger-Shaw theorem gives (under appropriate cyclicity hypotheses) a corresponding estimate on the trace of $[S^*,S]$. Of course these results hold when $S$ is subnormal. In the subnormal setting, the author obtains useful estimates on the norm and essential norm of

Genetic structure of the diploid–polyploid fish Squalius alburnoides in southern Iberian basins Tejo and Guadiana, based on microsatellites

Several studies have demonstrated the hybrid origin of Squalius alburnoides, a complex of diploid, triploid and tetraploid fish, with Squalius pyrenaicus as the maternal ancestor and an Anaecypris hispanica-like species as the paternal ancestor. The aim of this study was to assess patterns of genetic diversity and similarity between sympatric forms of the different ploidy levels of S. alburnoides

Residual platelet ADP reactivity after clopidogrel treatment is dependent on activation of both the unblocked P2Y(1) and the P2Y (12) receptor and is correlated with protein expression of P2Y (12).

Two ADP receptors have been identified on human platelets: P2Y(1) and P2Y(12). The P2Y(12) receptor blocker clopidogrel is widely used to reduce the risks in acute coronary syndromes, but, currently, there is no P2Y(1) blocker in clinical use. Evidence for variable responses to clopidogrel has been described in several reports. The mechanistic explanation for this phenomenon is not fully understoo

The Agenda-Shaping Powers of the EU Council Presidency

Existing literature is overwhelmingly sceptical about the capacity of the Council Presidency to shape the EU agenda. The Presidency's ability to promote private concerns is considered highly limited and, typically, the Presidency is depicted as a "responsabilité sans pouvior'. This article challenges the conventional wisdom on theoretical and empirical grounds. Theoretically, it develops a concept

Suicide-attempters having immunoglobulin G with affinity for doparnine in cerebrospinal fluid

Altered immunological functions and changes in the monoaminergic neurotransmitter systems are two important observations made previously in the study of possible etiological and pathophysiological factors for psychiatric disorders. In search of tentative autoimmune mechanisms involved in these disorders we studied the presence of immunoglobulin G (DA-IgG) with affinity for the monoamine dopamine (

Model process for separation based on unfolding and refolding of chymotrypsin inhibitor 2 in thermoseparating polymer two-phase systems

For the design of a new separation process based on unfolding and refolding of protein, the partitioning behaviour of proteins was studied in thermoseparating polymer two-phase systems with varying pH and temperature. Chymotrypsin inhibitor 2 (CI2), which unfolds reversibly in a simple two-state manner, was partitioned in an aqueous two-phase system (ATPS) composed of a random copolymer of ethylen

A decision support system improves the interpretation of myocardial perfusion imaging.

PURPOSE: The aim of this study was to investigate the influence of a computer-based decision support system (DSS) on performance and inter-observer variability of interpretations regarding ischaemia and infarction in myocardial perfusion scintigraphy (MPS). METHODS: Seven physicians independently interpreted 97 MPS studies, first without and then with the advice of a DSS. Four physicians had long

Illness-related complaints in women with chronic widespread pain: importance of a contextual approach

The study, comprising 125 sick-listed women aged 25-64 (m = 46.9 years) with widespread chronic pain, aimed at evaluating biopsychosocial problems as perceived by these women, studying such problems within a contextual framework, relating the findings to sociodemographic and medical data. Musculoskeletal complaints, fatigue, inability to work, sleep disturbances and uncertainty about the future we