OBJECTIVE - To analyze the effect of antibodies to glutamic acid decarboxylase (GAD65Ab) and islet cells (ICA512Ab) on glycemic control early in IDDM. RESEARCH DESIGN AND METHODS - GAD65Ab and ICA512Ab were measured twice in 35 patients (10 male, 25 female; age 1040 years) initially within 2 years of diagnosis and again 1 year later. The glycosylated hemoglobin was measured one to four times each

Serine hydroxymethyltransferase 2 (SHMT2) regulates one-carbon transfer reactions that are essential for amino acid and nucleotide metabolism, and uses pyridoxal-5′-phosphate (PLP) as a cofactor. Apo SHMT2 exists as a dimer with unknown functions, whereas PLP binding stabilizes the active tetrameric state. SHMT2 also promotes inflammatory cytokine signalling by interacting with the deubiquitylatin

We present a study of lνbb and l++l-bb production at hadron colliders. Our results, accurate to the next-to-leading order in QCD, are based on automatic matrix-element calculations performed byMadLoop andMadFKS, and are given at both the parton level, and after the matching with the Herwig event generator, achieved with aMC@NLO. We retain the complete dependence on the bottom-quark mass, and inclu

The next-to-leading order accuracy for MC@NLO results exclusive in J light jets is achieved if the computation is based on matrix elements that feature J and J + 1 QCD partons. The simultaneous prediction of observables which are exclusive in different light-jet multiplicities cannot simply be obtained by summing the above results over the relevant range in J; rather, a suitable merging procedure

We present an interface between the multipurpose Monte Carlo tool MadGraph5_aMC@NLO and the automated amplitude generator GoSam. As a first application of this novel framework, we compute the NLO corrections to (Formula presented.) (Formula presented.) and (Formula presented.) (Formula presented.) matched to a parton shower. In the phenomenological analyses of these processes, we focus our attenti

Global dementia rates will more than triple by 2050, thus challengingsociety. Due to ageing in place policies, informal caregiving is increasing asmore people with dementia continue living at home despite significant careneeds. While most caregivers are willing to act as such, they are notalways adequately supported, thus reporting a high burden, worse mentaland physical health. Innovative Assisti

Alzheimer's disease has a long preclinical phase during which amyloid pathology and neurodegeneration accumulate in the brain without producing overt cognitive deficits. It is currently unclear whether these early disease stages are associated with a progressive disruption in the communication between brain regions that subsequently leads to cognitive decline and dementia. In this study we assesse

The origin of cometary volatiles remains a major open question in planetary science. Comets may have either agglomerated from crystalline ices condensed in the protosolar nebula (PSN) or from amorphous ice originating from the molecular cloud and interstellar medium. Here, based on the recent argon, krypton, and xenon measurements performed by the ROSINA mass spectrometer on board the European Spa

The ice giants Uranus and Neptune are the least understood class of planets in our solar system but the most frequently observed type of exoplanets. Presumed to have a small rocky core, a deep interior comprising ∼70% heavy elements surrounded by a more dilute outer envelope of H 2 and He, Uranus and Neptune are fundamentally different from the better-explored gas giants Jupiter and Saturn. Becau

Vi reser ut från planeten Jorden, förbi Månen och planeterna i vårt solsystem, ut bland stjärnorna. Vi får reda på hur långt ut vi har, än så länge, skickad våra astronomer och våra rymdsonder. Vi får reda på hur litet det avståndet är jämfört med avståndet som sträcker sig mellan avlägsna stjärnor. Vi reser vidare och observerar hela vår galax, Vintergatan, Vi observerar hur det dvärggalaxer och We leave planet Earth and fly past the Moon and the planets in our Solar System. Out among the stars. We observe how far our astronauts and space probes have traveled, so far, and we discover how that distance compares to the enormous distances between the stars surrounding us.We go further and get to see our entire galaxy, the Milky Way. We observe how dwarf galaxies and globular clusters orbit o

GAD65Ab and ICA512Ab are strongly associated with insulin-dependent (Type 1) diabetes mellitus. A novel, simple radio-antigen binding assay with microSepharose conjugated with monoclonal antibodies specific for human immunoglobulin light chains was developed to provide diagnostic sensitivity and specificity of GAD65Ab and ICA512Ab for Type 1 diabetes. The Receiver Operating Characteristic (ROC) cu

Background: The bladder exstrophy-epispadias complex (BEEC) is a congenital malformation of the bladder and urethra. The underlying causes of this malformation are still largely unknown; however, aside from environment, genetics is thought to play an essential role. The recurrent 22q11.2 microduplication is the most persistently detected genetic aberration found in BEEC cases. Methods: We performe

The ability of echocardiography to diagnose sources of embolism and the role of the examination in the prediction of thromboembolism are reviewed. In addition, the yield of transthoracic (TTE) and transoesophageal echocardiography (TEE) is analysed in patients with suspected embolism and guidelines are proposed for performing echocardiography in this setting. In general, echocardiography is reliab

This paper describes a search for pairs of neutral, long-lived particles decaying in the ATLAS calorimeter. Long-lived particles occur in many extensions to the Standard Model and may elude searches for new promptly decaying particles. The analysis considers neutral, long-lived scalars with masses between 5 and 400 GeV, produced from decays of heavy bosons with masses between 125 and 1000 GeV, whe