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Breaking barriers : a statistical and machine learning-based hybrid system for predicting dementia

Introduction: Dementia is a condition (a collection of related signs and symptoms) that causes a continuing deterioration in cognitive function, and millions of people are impacted by dementia every year as the world population continues to rise. Conventional approaches for determining dementia rely primarily on clinical examinations, analyzing medical records, and administering cognitive and neur

Detection of Pre-and Post-Trigger Atrial Fibrillation in Long-Term Photoplethysmogram Signals Acquired in Free-Living

Modifiable factors, such as alcohol or physical exertion, may trigger atrial fibrillation (AF) episodes. Identifying and eliminating these triggers can lead to effective strategies which reduce risk of AF recurrence. This study aims to evaluate pre-and post-trigger AF in long-term photo-plethysmogram (PPG) signals obtained during daily living from patients with paroxysmal AF. Thirty-seven patients

The Corded Ware Complex in Europe in Light of Current Archaeogenetic and Environmental Evidence

Corded Ware is one of the main archaeological phenomena of the third millennium before the common era (BCE), with a wide geographic spread across much of central and northeastern Europe, from Denmark, the Rhineland, and Switzerland in the west to the Baltic and Western Russia in the east, and broadly restricted to the temperate, continental zones north of the Alps, the Carpathians, and the steppe/

Reconfiguration of cognitive control networks during a long-duration flanker task

Continuous task engagement generally leads to vigilance decrement and deteriorates task performance. However, how conflict effect is modulated by vigilance decrement has no consistent evidence, and little is known about the underlying neural mechanisms. Here we adopted an electroencephalogram dataset collected during a prolonged flanker task to examine the interactions between vigilance and congru

Structural basis of Cfr-mediated antimicrobial resistance and mechanisms to evade it

The bacterial ribosome is an essential drug target as many clinically important antibiotics bind and inhibit its functional centers. The catalytic peptidyl transferase center (PTC) is targeted by the broadest array of inhibitors belonging to several chemical classes. One of the most abundant and clinically prevalent resistance mechanisms to PTC-acting drugs in Gram-positive bacteria is C8-methylat

Retrospective validation study of an artificial neural network-based preoperative decision-support tool for noninvasive lymph node staging (NILS) in women with primary breast cancer (ISRCTN14341750)

Background: Surgical sentinel lymph node biopsy (SLNB) is routinely used to reliably stage axillary lymph nodes in early breast cancer (BC). However, SLNB may be associated with postoperative arm morbidities. For most patients with BC undergoing SLNB, the findings are benign, and the procedure is currently questioned. A decision-support tool for the prediction of benign sentinel lymph nodes based

Heat transfer enhancement with additively manufactured rough surfaces: Insights from large-eddy simulations

To study the impact of additively manufactured (AM) roughness on fluid flow and heat transfer, we performed a series of high-fidelity large-eddy simulations on turbulent heat transfer over a three-dimensional AM rough surface with varying bulk Reynolds number and average roughness height values. We considered rough surfaces created using AM techniques at Siemens based on Nickel Alloy IN939 materia

Polygon Detection for Room Layout Estimation using Heterogeneous Graphs and Wireframes

This paper presents a neural network based semantic plane detection method utilizing polygon representations. The method can for example be used to solve room layout estimations tasks and is built on, combines and further develops several different modules from previous research. The network takes an RGB image and estimates a wireframe as well as a feature space using an hourglass backbone. From t

Neighbourhood socioeconomic status and pain among older adults—A cross-sectional study

Background: Pain is associated with falls, disability and a poor quality of life among older adults. It is highly prevalent in many societies, and studies have shown that pain could be preventable or managed more effectively at the population level. However, few studies have investigated who is at higher risk of pain in the general population, which is important for development of effective interv

Photonic sensors reflect variation in insect abundance and diversity across habitats

To mitigate ongoing insect biodiversity declines, there is a need for efficient yet accurate monitoring methods. The use of traditional catch-based survey methods is constrained both by costs and need for expertise for manual taxonomic identification. Emerging methods, such as eDNA and robotic sorting, have the potential to reduce workload but still require resource-intensive sample collection in

Proximity and Inequality in Academia

When mattering is defined as being able to disseminate ideas on a global scale, not all universities and researchers matter equally. Along with many other factors, geographical location can be a source of inequality in the science system, which is characterized by a persistent core–semi-periphery–periphery structure. Collaboration between high-, middle-, and low-income countries, frequently enable

NATO or Not

Using a framework for analyzing security policy consisting of a synthesis of the Multiple Streams Framework by Kingdon (2014) and Securitization theory as described by Balzacq (2010), this study aims to explain the process of Sweden’s national security policy between 2014 and 2022. Such an investigation has relevance particularly for studies of peace, security and policy processes, since it relate

Outcomes and performance of the ACURATE neo2 transcatheter heart valve in clinical practice : one-yearresults of the ACURATE neo2 PMCF Study

BACKGROUND: Transcatheter aortic valve implantation is an effective treatment for patients with aortic stenosis; however, complications related to paravalvular leakage (PVL) persist, including increased risk of mortality, cardiovascular mortality, and rehospitalisation. AIMS: We sought to evaluate the clinical outcomes and valve performance at 1 year in patients with severe aortic stenosis treated

Detecting potential outliers in longitudinal data with time-dependent covariates

Background: Outliers can influence regression model parameters and change the direction of the estimated effect, over-estimating or under-estimating the strength of the association between a response variable and an exposure of interest. Identifying visit-level outliers from longitudinal data with continuous time-dependent covariates is important when the distribution of such variable is highly sk

Real estate crisis resolution regimes and residential REITs : emerging socio-spatial impacts in Barcelona

This paper explores the development of residential Spanish Real Estate Investment Trusts (REITs, known as SOCIMIs) in the country’s growing rental market, unpacking their connection with the resolution of the 2008 financial crisis. Focus is placed on the emerging socio-spatial dynamics of one of the country’s first large-scale residential SOCIMIs in Barcelona from the global private equity firm Bl

Adapting the environmental risk transition theory for urban health inequities : An observational study examining complex environmental riskscapes in seven neighborhoods in Global North cities

Theories of epidemiologic transition analyze the shift in causes of mortality due to changes in risk factors over time, and through processes of urbanization and development by comparing risk factors between countries or over time. These theories do not account for health inequities such as those resulting from environmental injustice, in which minority and lower income residents are more likely t

Natural outdoor environments’ health effects in gentrifying neighborhoods : Disruptive green landscapes for underprivileged neighborhood residents

Background: Cities are restoring existing natural outdoor environments (NOE) or creating new ones to address diverse socio-environmental and health challenges. The idea that NOE provide health benefits is supported by the therapeutic landscapes concept. However, several scholars suggest that NOE interventions may not equitably serve all urban residents and may be affected by processes such as gent

Effekter av statisk stretching på muskelstyrka - En litteraturstudie

Denna litteraturstudie visar att statisk stretching har olika utfall på muskelstyrkan beroende på vilken typ av effekt som undersöks men även val av stretching intervention. Akuta effekter på muskelstyrkan är mer undersökt än långsiktiga effekter. Flertalet studier i denna litteraturstudie visar att långvarig statisk stretching innan träning (akuta effekter) påverkar muskelstyrkan negativt. I kont