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Hoxa9/hoxb3/hoxb4 compound null mice display severe hematopoietic defects

Obyective. Members of the box family of homeodomain-containing transcription factors, including hoxa9, hoxb3, and hoxb4 play an important role in the regulation of differentiation, proliferation and self-renewal of hematopoietic stem and progenitor cells. Lack-of-function studies using hoxa9, hoxb4, or hoxb3/hoxb4 null mice demonstrate that all these mutations compromise the repopulating ability o

Significance of a halysitid-heliolitid mud-facies autobiostrome from the Middle Silurian of Gotland, Sweden.

A low-diversity halysitid-heliolitid autobiostrome from the Late Wenlock Halla Formation at Blåhäll 1, Gotland, indicates a brief period of particular environmental conditions. The reef is 0.3–0.5 m thick, internally without bedding structures, and had a sheet-like distribution on a low-relief soft-bottom, in marginal platform, graptolitiferous strata (height-width ratio is 1:900 in outcrop). The

Blood pressure and other cardiovascular risk factors among treated hypertensives in Swedish primary health care

Objective - To evaluate antihypertensive treatment and other cardiovascular risk factors in primary health care. Design - Cross-sectional survey of consecutive patients with treated hypertension in 1999. Setting - 17 primary care centres in Sweden. Subjects - 512 patients (mean age 67; SD 11 years). Main outcome measures - Antihypertensive treatment, cardiovascular risk factors. Results - Patients

Cutaneous human papillomavirus 88: Remarkable differences in viral load.

A human papillomavirus (HPV) was cloned from a patient with multiple squamous cell carcinomas (SCCs) and identified as HPV88, recently categorized into a new species within the genus Gamma. The HPV88 viral load in an SCC of the index patient exceeded 1 million copies/cell. By contrast, a survey of 447 skin lesions (79 actinic keratoses, 73 seborrhoeic keratoses, 169 basal cell carcinomas and 126 S

Demand-driven evaluation of collection attributes

n order to make attribute grammars useful for complicated analysis tasks, a number of extensions to the original Knuth formalism have been suggested. One such extension is the collection attribute mechanism, which allows the value of an attribute to be defined as a combination of contributions from distant nodes in the abstract syntax tree. Another extension that has proven useful is circular attr

Optimal design of plate heat exchangers with and without pressure drop specifications

The traditional design method for plate heat exchangers(PHEs), either epsilon-number of transfer units (epsilon-NTU) or logarithmic mean temperature difference method, involves many trials in order to meet the pressure drop constraints. This can be avoided through the developed design method, which takes the full utilization of the allowable pressure drops as a design objective. The proposed metho

Daily physical activity and its relation to aerobic fitness in children aged 8-11 years.

A positive relationship between daily physical activity and aerobic fitness exists in adults. Studies in children have given conflicting results, possibly because of differences in methods used to assess daily physical activity and fitness. No study regarding daily physical activity and fitness in children has been published, where fitness has been assessed by direct measurement of maximum oxygen

Ice-dammed lakes and rerouting of the drainage of northern Eurasia during the Last Glaciation

During the Quaternary period, ice sheets centred over the Barents and Kara seas expanded several times onto mainland Russia and blocked northflowing rivers, such as the Yenissei, Ob, Pechora and Mezen. Large ice-dammed lakes with reversed outlets, e.g. toward the Caspian Sea, formed south of these ice sheets. Some lakes are reconstructed from shorelines and lacustrine sediments, others mainly from

Seasonal denitrification potential in wetland sediments with organic matter from different plant species

Vegetation both physically and biochemically influences denitrification in wetlands. Litter from various plant species supplies various amounts and qualities of organic carbon to denitrifying bacteria, and may thus affect denitrification capacity. We explore whether there is seasonal variation in the denitrification potential in stands of Glyceria maxima, Phragmites australis, Typha latifolia, and

Selective etching of III-V nanowires for molecular junctions

Selective etching of heterostructure III-V nanowires can be used to form tips and narrow gaps simultaneously on multiple nanowires on a single wafer. In this study we tested bromine based etching of gallium arsenide segments in gallium phosphide nanowires. Depending on the etchant and etching conditions, a variety of gap topologies and tip-like structures were observed. The method is compatible wi

Mate choice, male condition-dependent ornamentation and MHC in the pheasant

The Hamilton and Zuk model predicts that genes for resistance to various pathogens may be continuously heritable due to selection disequilibria caused by coadaptional cycles of hosts and pathogens. The model further suggests that the expression of male secondary ornaments is condition-dependent and that only individuals with superior genetic disease resistance and vigour can fully express exaggera

Holocene organic carbon burial rates in the Baltic coast

To estimate Holocene changes in organic carbon mass accumulation rates (Corg MARs) in the southeastern Swedish Baltic Sea, two sediment cores were studied in combination with biogeochemical modelling. Prior to 11 300 cal. BP, Corg MARs were extremely low, indicating low organic matter production on the catchment of the Baltic Ice Lake. Following a brief regression, the Ancylus Lake stage occurred

Performance of the projectile fragmentation wall at CELSIUS storage ring

The projectile fragmentation wall [Budzanowski, A. et al., Nucl. Instr. Meth. A482, 528 (2002).] (PFW) is a part of it bigger detection system comprising of the CHICSi detector [Jakobsson, B., Nucl. Phys. News Int. 9:2 22 (1999). Siwek, A., Nucl. Phys., A654, 2695 (1999)] and a recoil detectors array [Kuznetsov, A. V. et al, Nucl. Instr. Meth. A452, 525 (2000)]. The system is designed to register

Progress in miniaturisation of proteon arrays - a step closer to high-density nanoarrays

Protein microarrays is a technology with great promise for high-throughput proteomics. Designing high-performance protein microarrays for global proteome analysis has, however, turned out to be challenging. To this end, major efforts are under way to design novel array formats capable of harboring the tremendous range of probes required to target complex proteomes composed of more than 10 000 anal

Climacteric medicine: European Menopause and Andropause Society (EMAS) 2004/2005 position statements on peri- and postmenopausal hormone replacement therapy

In women experiencing distressing climacteric symptoms during the peri- and postmenopause there is conclusive evidence from abundant randomised controlled trials that systemic hormone replacement therapy (HRT) of any type affords symptom relief, with no alternative treatment producing similar effect. Though this evidence is accumulating, the question of how to provide best clinical practice in an

VHY, a novel myristoylated testis-restricted dual specificity protein phosphatase related to VHX

The human DUSP15 gene encodes an uncharacterized 235-amino acid member of the subfamily of small dual specificity protein phosphatases related to the Vaccinia virus VH1 phosphatase. Similar to VHR-related MKPX (VHX) (DUSP22), the predicted protein has an N-terminal myristoylation recognition sequence, and we show here that both are indeed modified by the attachment of a myristate to Gly-2. In reco