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Insights into the Hierarchical Assembly of a Chemically Diverse Peptide Hydrogel Derived from Human Semenogelin I

A peptide corresponding to a 13-residue segment of the human protein semenogelin I has been shown to generate a hydrogel consisting of amyloid-like fibrils. The relative chemical diversity (compared to synthetic de novo sequences) with 11 distinct amino acids makes this peptide (P0) an ideal candidate for investigating the role of individual residues in gelation. Herein, the N-terminal residues ha

Longitudinal molecular profiling elucidates immunometabolism dynamics in breast cancer

Although metabolic reprogramming within tumor cells and tumor microenvironment (TME) is well described in breast cancer, little is known about how the interplay of immune state and cancer metabolism evolves during treatment. Here, we characterize the immunometabolic profiles of tumor tissue samples longitudinally collected from individuals with breast cancer before, during and after neoadjuvant ch

Imaging NRF2 activation in non-small cell lung cancer with positron emission tomography

Mutations in the NRF2-KEAP1 pathway are common in non-small cell lung cancer (NSCLC) and confer broad-spectrum therapeutic resistance, leading to poor outcomes. Currently, there is no means to non-invasively identify NRF2 activation in living subjects. Here, we show that positron emission tomography imaging with the system xc- radiotracer, [18F]FSPG, provides a sensitive and specific marker of NRF

(G)Patching up mis-splicing in cancer

Benbarche, Pineda, Galvis, et al. delineate an essential role for the G-patch motif-containing protein GPATCH8 in mis-splicing associated with cancer-driving mutations of the splicing factor SF3B1. GPATCH8 cooperates with SF3B1 mutants, affecting the splicing machinery. Targeting GPATCH8 reveals therapeutic opportunities for SF3B1 mutant cancers and other splicing-related diseases.

The hepatitis C virus envelope protein complex is a dimer of heterodimers

Fifty-eight million individuals worldwide are affected by chronic hepatitis C virus (HCV) infection, a primary driver of liver cancer for which no vaccine is available1. The HCV envelope proteins E1 and E2 form a heterodimer (E1/E2), which is the target for neutralizing antibodies2. However, the higher-order organization of these E1/E2 heterodimers, as well as that of any Hepacivirus envelope prot

The effect of audit and feedback and implementation support on guideline adherence and patient outcomes in cardiac rehabilitation : a study protocol for an open-label cluster-randomized effectiveness-implementation hybrid trial

Background: Providing secondary prevention through structured and comprehensive cardiac rehabilitation programmes to patients after a myocardial infarction (MI) reduces mortality and morbidity and improves health-related quality of life. Cardiac rehabilitation has the highest recommendation in current guidelines. While treatment target attainment rates at Swedish cardiac rehabilitation centres is

Boosting Membrane Interactions and Antimicrobial Effects of Photocatalytic Titanium Dioxide Nanoparticles by Peptide Coating

Photocatalytic nanoparticles offer antimicrobial effects under illumination due to the formation of reactive oxygen species (ROS), capable of degrading bacterial membranes. ROS may, however, also degrade human cell membranes and trigger toxicity. Since antimicrobial peptides (AMPs) may display excellent selectivity between human cells and bacteria, these may offer opportunities to effectively “tar

Shifts in soil C stabilization mechanisms are linked to reindeer-induced changes in plant communities and associated fungi in subarctic tundra

Arctic tundra ecosystems store a significant proportion of the global soil organic carbon (C). However, warming-induced shrub encroachment and reindeer (Rangifer tarandus L.) grazing regimes promoting graminoid vegetation may strongly influence tundra soil C stability. Here, we studied how reindeer grazing intensity and experimental warming affect soil C stabilization in a tundra ecosystem. We hyp

Heart failure with preserved ejection fraction management : a systematic review of clinical practice guidelines and recommendations

Multiple guidelines exist for the diagnosis and management of heart failure with preserved ejection fraction (HFpEF). We systematically reviewed current guidelines and recommendations, developed by national and international medical organizations, on the management of HFpEF in adults to aid clinical decision-making. We searched MEDLINE and EMBASE on 28 February 2024 for publications over the last

Stakeholder interfaces for excess heat-based urban heat supply— Input from Swedish cases

Excess heat is generated from different industrial processes and from urban infrastructure (sewage water, transport, datacentres and buildings). Thirty-five percent of the European energy demand for heating and cooling could be met by excess heat. Today, however, this energy reserve is barely exploited. There are known barriers to excess heat recovery but limited information on stakeholder interac

Lifestyle and cardiovascular risk in working young adults : insights from a nationwide Spanish cohort

Introduction and objectives: This study aimed to describe the cardiovascular risk profile of working young adults from Spain and its association with lifestyle. Methods: Participants (18-30 years) were recruited from a nationwide cohort of economically active adults insured by a large occupational risk prevention company, with data obtained from routine medical assessments. The participants were c

Challenging the green machine : Rejoinder to Schwartzman

We respond to David Schwartzman’s critique of our paper. We argue that his“solar communism,” his approach to the question of energy return on energyinvestment (EROI), and his critique of Georgescu-Roegen’s fourth law ofthermodynamics situate him as a left ecomodernist, albeit with sympathy fordegrowth. Schwartzman’s take on these issues illustrates how the ontologicalseparation of human ingenuity

Patient-related prognostic factors for function and pain after shoulder arthroplasty : a systematic review

Background: While shared decision making is a cornerstone of orthopedic care, orthopedic surgeons face challenges in tailoring their advice and expectation management to individual shoulder arthroplasty patients due to the lack of systematically summarized evidence-based knowledge. This systematic review aims to provide an overview of current knowledge on independent predictive effects of patient-

Linearly convergent nonoverlapping domain decomposition methods for quasilinear parabolic equations

We prove linear convergence for a new family of modified Dirichlet–Neumann methods applied to quasilinear parabolic equations, as well as the convergence of the Robin–Robin method. Such nonoverlapping domain decomposition methods are commonly employed for the parallelization of partial differential equation solvers. Convergence has been extensively studied for elliptic equations, but in the case o

Skin Anatomy, Bone Histology and Taphonomy of a Toarcian (Lower Jurassic) Ichthyosaur (Reptilia: Ichthyopterygia) from Luxembourg, with Implications for Paleobiology

A partial ichthyosaur skeleton from the Toarcian (Lower Jurassic) bituminous shales of the ‘Schistes Carton’ unit of southern Luxembourg is described and illustrated. In addition, associated remnant soft tissues are analyzed using a combination of imaging and molecular techniques. The fossil (MNHNL TV344) comprises scattered appendicular elements, together with a consecutive series of semi-articul

Hypoaldosteronism due to a novel SEC61A1 variant successfully treated with fludrocortisone

Background: Genetic variants in SEC61A1 are associated with autosomal dominant tubulointerstitial kidney disease. SEC61A1 is a translocon in the endoplasmic reticulum membrane and variants affect biosynthesis of renin and uromodulin. Methods: A patient is described that presented at 1 year of age with failure-to-thrive, kidney failure (glomerular filtration rate, GFR, 18 ml/min/1.73m2), hyperkalem

2D Vanadium Sulfides : Synthesis, Atomic Structure Engineering, and Charge Density Waves

Two ultimately thin vanadium-rich 2D materials based on VS2 are created via molecular beam epitaxy and investigated using scanning tunneling microscopy, X-ray photoemission spectroscopy, and density functional theory (DFT) calculations. The controlled synthesis of stoichiometric single-layer VS2 or either of the two vanadium-rich materials is achieved by varying the sample coverage and sulfur pres

The Role of Small-Bowel Capsule Endoscopy in the Diagnostic Algorithm of Complicated Perianal Disease

Introduction: Complicated perianal disease (cPD) may be the sole presentation of Crohn’s disease (CD). The role of small-bowel capsule endoscopy (SBCE) in the diagnostic algorithm of cPD is unclear. We aimed to evaluate the role of SBCE as a diagnostic tool, in patients with cPD, after a negative standard workup for CD. Methods: A multicenter, retrospective, cross-sectional study, in patients with