Familial, sequencing, and genome-wide association studies (GWASs) and genetic correlation analyses have progressively unraveled the shared or pleiotropic germline genetics of breast and ovarian cancer. In this study, we aimed to leverage this shared germline genetics to improve the power of transcriptome-wide association studies (TWASs) to identify candidate breast cancer and ovarian cancer suscep

The vast majority of the energy consumed for urban water services is used to heat tap water. Heat recovery from wastewater is consequently an area of rapidly growing concern, both in research and by commercial interest, promoting the path towards a circular economy. To facilitate a system-wide evaluation of heat recovery from wastewater, this paper compares two one-dimensional models (mechanistic

Objective: To report on safety and effectiveness of subcutaneous cladribine (Litak®) in multiple sclerosis (MS) patients. Methods: Litak® was offered to MS-patients irrespective of disease course. Litak® 10 mg was administered for 3–4 days during week 1. Based on lymphocyte count at week 4, patients received another 0–3 doses at week 5. A second course was administered 11 months later. Follow-up i

Accurate fluid pressure in the fetal lung is critical for its development, especially at the beginning of the saccular stage when alveolar epithelial type 1 (AT1) and type 2 (AT2) cells differentiate from the epithelial progenitors. Despite our growing understanding of the role of physical forces in lung development, the molecular mechanisms that regulate the transduction of mechanical stretch to

Purpose: To investigate how an artificial intelligence (AI) system performs at digital mammography (DM) from a screening population with ground truth defined by digital breast tomosynthesis (DBT), and whether AI could detect breast cancers at DM that had originally only been detected at DBT. Materials and Methods: In this secondary analysis of data from a prospective study, DM examinations from 14

Syftet med den här avhandlingen var att undersöka om användningen avpersonlighet i teamforskning kan göras på ett sådant sätt att individuella skillnader,som är det som typiskt studeras i personlighetsforskning, bibehålls. Två olika sättatt applicera personlighet i teamforskning, utan att ändra analysenheten frånindivider till team, föreslogs och demonstrerades med exempeldata. Personlighethos indThe aim of this doctoral dissertation was to investigate whether the application of personality in team research canbe performed so that the individual differences, that are typically studied in personality research, are maintained.Two different approaches to apply personality to team research, without changing the unit of study from individualsto teams, were suggested and demonstrated with exampl

Vitamin A supplementation for children 6-59 months old is an important intervention that boosts immune function, especially where children do not consume enough vitamin-A-rich foods. However, the low coverage of vitamin A supplementation is a persistent problem in low- and middle-income countries. We first estimated the percentage of children 6-23 months old receiving the minimum dietary diversity

Svensk byggindustri är under förändring. Stora delar av produktionen läggs idag ut på entreprenad och byggföretag förlitar sig på underentreprenörer i större utsträckning än tidigare. Som en del av en global trend av kostnadsreducering inom byggindustrin, försöker byggföretag minimera antalet anställda hantverkare och istället utkontraktera arbete till underentreprenörer i strävan efter organisatoThe organisation of work in the Swedish building sector is changing due to increased subcontracting and the adoption of construction management. In this study, construction management refers to a specific subcontracting regime, in which contractors externalise all parts of the production process and organise work through subcontractors. Echoing global trends of cost-cutting, this externalisation b