For the amine transaminase (ATA)-catalyzed synthesis of chiral amines, the choice of donor substrate is of high importance for reaction and process design. Alanine was investigated as an amine donor for the reductive amination of a poorly water-soluble ketone (4-phenyl-2-butanone) in a combined in situ product removal (ISPR) approach using liquid-membrane extraction together with an enzyme cascade

The recent discovery of a subfossil polar bear (Ursus maritimus) jawbone in the Poolepynten coastal cliff sequence, western Svalbard, and its implications for the natural history of the polar bear motivated an effort to better constrain the environmental history and age envelope of the Poolepynten sediment sequence. The focus of the present study is on the lithostratigraphy of the coastal cliffs a

Increased age, BMI and HbA1c levels are risk factors for several non-communicable diseases. However, the impact of these factors on the genome-wide DNA methylation pattern in human adipose tissue remains unknown. We analyzed DNA methylation of ∼480,000 sites in human adipose tissue from 96 males and 94 females, and related methylation to age, BMI and HbA1c. We also compared epigenetic signatures i

Cardiac dysfunction has been shown in cases of placental insufficiency, but few reports exist on fetal atrial function. The aim of this study was to generate reference values for atrial strain and compare them to results in fetuses with signs of increased placental resistance and abnormal venous circulation.

Our aim was to study how breast density relates to tumor characteristics in breast cancer with emphasis on mode of detection. Among 17,035 women in the Malmö Diet and Cancer Study 826 incident cases have been diagnosed (1991-2007). Data on tumor characteristics, mode of detection, and density at diagnosis were collected. Associations between density and tumor characteristics were analyzed using lo

A Diels-Alder reaction is used as a key step in a synthetic study toward communesin F, in order to simultaneously introduce both of the all-carbon quaternary stereocenters with complete control of relative stereochemistry. Further manipulations of the cycloadduct, toward the hexacyclic core-structure of communesin F, are also disclosed.

Abstract Clinical measurements are necessary in many routine follow-ups and scientific evaluations, but the accuracy of these measurements is seldom challenged. The size of the reconstructed ear is one important parameter in the follow-up regarding patients operated on due to microtia. With the introduction of digital morphometry one was obliged to evaluate its accuracy in comparison to its analog

Compassion may be directed at a broad range of targets. The present study investigated interrelations among other-directed compassion, self-compassion and environmental compassion in early adolescence (age 12-14; N = 256) and examined how the different manifestations of compassion related to age and sex during this age period. Dispositional compassion directed at different targets was assessed thr

Fisheries exemplify the immense complexity of interactions in social-ecological systems (SESs). This complexity has created management challenges and raises concerns for the sustainability of our marine natural resource systems. This article contributes to SES fisheries research and management in two ways: first, it enhances our understanding of lobster fisheries as complex social-ecological syste

Thaw lakes in permafrost areas are sources of the strong greenhouse gas methane(1-5). They develop mostly in sedimentary lowlands with permafrost and a high excess ground ice volume, resulting in large areas covered with lakes and drained thaw-lake basins (DTLBs; refs 6,7). Their expansion is enhanced by climate warming, which boosts methane emission and contributes a positive feedback to future c

Given a set of commodities and a network where some arcs can fail while others are reliable, we consider a routing problem with respect to a survivability requirement that each commodity can be split among pairs of failure-disjoint paths. Two paths p and p′ form a pair of failure-disjoint paths if they share only reliable arcs. The same flow is sent over p and p′, but the flow sent on a common rel

BRCA1-associated breast and ovarian cancer risks can be modified by common genetic variants. To identify further cancer risk-modifying loci, we performed a multi-stage GWAS of 11,705 BRCA1 carriers (of whom 5,920 were diagnosed with breast and 1,839 were diagnosed with ovarian cancer), with a further replication in an additional sample of 2,646 BRCA1 carriers. We identified a novel breast cancer r

We applied the new injury severity scoring system and studied mechanisms of injury and risk factors for mortality, in order to find potential preventive measures, in the present Scandinavian trauma cohort triaged through red trauma alarm according to the Medical Emergency Triage and Treatment System.

Global change may substantially affect biodiversity and ecosystem functioning but little is known about its effects on essential biotic interactions. Since different environmental drivers rarely act in isolation it is important to consider interactive effects. Here, we focus on how two key drivers of anthropogenic environmental change, climate change and the introduction of alien species, affect p

Aim: Our aim was to test the hypothesis that dual endothelin receptor blockade with tezosentan attenuates hypoxia induced pulmonary vasoconstriction. Methods: 14 anaesthetised, ventilated pigs, with a mean±SEM weight of 30,5±0,6 kg, were studied, in normoxia (FiO(2) â0,21) and with tezosentan (5mg·kg(-1) ) infusion during (n=7) or before (n=7) hypoxia (FiO(2) ∼0,10). Results: Compared to normoxia,

We have recorded extreme ultraviolet spectra from W11+ to W15+ ions using a flat-field spectrometer installed at the Shanghai high-temperature superconducting electron-beam ion trap. The spectra were recorded at beam energies ranging between 200 and 400 eV and showed spectral lines and transition arrays in the 170-260 angstrom region. The charge states and spectra transitions were identified by co