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Huntington's disease (HD) is an inherited neurodegenerative disorder caused by a CAG repeat expansion in the huntingtin (HTT) gene. Both central and peripheral innate immune activation have been described as features of the disease. Isolated human HD monocytes have been shown to produce more cytokines upon LPS stimulation compared to control monocytes. Understanding alterations in the signalling c
Polyelectrolytes with amphiphilic counterions, PEACs, are water insoluble because the amphiphiles self-assemble into highly charged micelles that strongly associate with the equally highly charged polyions. However, in the presence of water soluble cyclodextrins (CDs) that form inclusion complexes with the amphiphiles and prevent micellization, PEACs become soluble as the dispersed amphiphiles beh
Obituary of Professor Lars Österlin (1923-2006)
In this article we consider how the operator of an electric power system should activate bids on the regulating power market in order to minimize the expected operation cost. Important characteristics of the problem are reaction times of actors on the regulating market and ramp-rates for production changes in power plants. Neglecting these will in general lead to major underestimation of the opera
Viral vector-mediated gene transfer is emerging as a novel therapeutic approach with clinical utility in treatment of Parkinson's disease. Recombinant adeno-associated viral (rAAV) vector in particular has been utilized for continuous l-3,4 dihydroxyphenylalanine (DOPA) delivery by expressing the tyrosine hydroxylase (TH) and GTP cyclohydrolase 1 (GCH1) genes which are necessary and sufficient for
Addition of tri(2-furyl)phosphine. PFu(3), to [Os-3(CO)(10)(mu-H)(2)] at room temperature gives [HOs3(CO)(10)(PFu(3)) (mu-H)] (1), while in refluxing toluene the same reactants afford [Os-3(CO)(9)(mu(3)-PFu(2)(C4H2O))(mu-H)] (2) resulting from orthometallatation of a furyl ring. Reaction of PFu(3) with [Os-3(CO)(10-n)(NCMe)n] (n = 0, 1, 2) affords the substituted clusters [Os-3(CO)(12-n)(PFu(3))(n
The Child and Adolescent Twin Study in Sweden (CATSS) is an ongoing longitudinal twin study targeting all twins born in Sweden since July 1, 1992. Since 2004, parents of twins are interviewed regarding the children's somatic and mental health and social environment in connection with their 9th or 12th birthdays (CATSS-9/12). By January 2010, 8,610 parental interviews concerning 17,220 twins had be
Sleep plays a vital role in physical and mental functioning. It is increasingly recognized that disturbed sleep is a highly prevalent and chronic condition that merits greater awareness due to the wide-ranging and serious repercussions associated with it. Nocturia is one of the causes of sleep disturbance and has been shown to impair functioning, quality of life, health and productivity, with thos
A dietary fiber containing material, named as alcohol insoluble residue (AIR), was recovered from the olive mill wastewater (OMW). It was separated into different fractions (water soluble and insoluble AIR) and characterized with regard to fiber and ion content. Dynamic rheological tests of the water soluble fraction (WSAIR) were conducted in order to examine its gelling ability. Thereafter, AIR a
In this paper we present an investigation of to perform simultaneous measurements of the D/H-ratio by coincidence measurements using proton-proton scattering and proton-deuteron scattering or deuteron-deuteron scattering and deuteron-proton scattering. This is performed with the use of a double sided silicon strip detector (DSSSD), which provides both position information and energy information. T
The present study was conducted to explore whether single nucleotide polymorphisms (SNPs) in Th1 and Th17 cell-mediated immune response genes differentially influence the risk of rheumatoid arthritis (RA) in women and men. In phase one, 27 functional/tagging polymorphisms in C-type lectins and MCP-1/CCR2 axis were genotyped in 458 RA patients and 512 controls. Carriers of Dectin-2(rs4264222T) alle
The main purpose of the study was to investigate Hypothalamic-Pituitary-Adrenal (HPA) axis characteristics in relation to suicidal intent among suicide attempters with Major Depressive Disorder (MDD) and Adjustment Disorders (AD). The relationship between suicidal intent, assessed by means of the Suicidal Intent Scale (SIS), and serum cortisol after a Dexamethasone Suppression Test (DST) was inves
Coordination during disaster recovery is one of the most neglected areas of disaster risk management, as the majority of literature on coordination focuses on disaster response. The purpose of the study is to investigate the factors affecting coordination for long-term recovery. For this purpose, the study uses semi-structured interviews with different actors involved in the recovery process of th
The palynofloral changes around the Cretaceous-Paleogene (K-Pg) mass extinction event reveal the fine details of vegetation response to a global environmental crisis-in this case an asteroid impact in Mexico 65.5 million years ago. Due to the extinction of several plant taxa at the K-Pg boundary, palynostratigraphy is a prime tool for localizing the Cretaceous-Paleogene boundary in non-marine succ
Essay rereading Haraways Cyborg Manifesto
Divergent selection and local adaptation are responsible for many phenotypic differences between populations, potentially leading to speciation through the evolution of reproductive barriers. Here we evaluated the morphometric divergence among west European populations of Reed Bunting in order to determine the extent of local adaptation relative to two important selection pressures often associate
