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Non-conventional endpoints show higher sulfoxaflor toxicity to Chironomus riparius than conventional endpoints in a multistress environment

Evidence grows that standard toxicity testing might underestimate the environmental risk of neurotoxic insecticides. Behavioural endpoints such as locomotion and mobility have been suggested as sensitive and ecologically relevant additions to the standard tested endpoints. Possible interactive effects of chemicals and additional stressors are typically overlooked in standardised testing. Therefore

Effect of GB1107, a novel galectin-3 inhibitor on pro-fibrotic signalling in the liver

Background and purpose: Galectin-3 (Gal-3) is a pro-fibrotic β-galactoside binding lectin highly expressed in fibrotic liver and implicated in hepatic fibrosis. GB1107 is a novel orally active Gal-3 small molecule inhibitor that has high affinity for Gal-3 >1000-fold selectively over other galectins. The aim of this study was to characterise GB1107 and galectin-3 in vitro and in vivo in the contex

Impaired blood pressure regulation in post-COVID-19 postural orthostatic tachycardia syndrome: novel disease mechanisms beyond sinus tachycardia

Background: Postural orthostatic tachycardia syndrome (POTS) is a prevalent cardiovascular disorder after COVID-19 infection. Although POTS is characterized by the presence of sinus tachycardia, other hemodynamic disturbances including blood pressure (BP) regulation, remain largely unexplored.Aims: We investigated BP changes using 24-hour ambulatory-BP-monitoring in patients with new-onset POTS af

Collection display at MoMA : Aggregate States of Matters

With her film installation Aggregate States of Matters, Rosa Barba poses a question: How can a form of visual expression convey the environmental and social impact of an issue as fraught as climate change?For this work, the artist interviewed members of Indigenous Quechua communities in Peru, who have had to adapt their daily practices due to the melting of a nearby glacier. Abandoning journalisti

Assessment of intraepidermal nerve fiber densities in 5 µm sections from arm and leg - a search for normative age-related values

Background and aims: Normative values are lacking regarding intraepidermal nerve fiber density (IENFD) in thin sections of 5 µm. Thus, we aimed to assess IENFD in thin sections in a healthy adult population as well as to investigate whether IENFD is related to age, sex, and site of excision.Methods: Archival skin biopsies or excisions at the Department of Pathology, Lund, Sweden, from arm and leg

Inserted Between The Painted Glass

This exhibition of new sculptural works by the artist coincides with the launch of a new series of prints by Rosa Barba published by, and only available through Cahiers d’Art; featuring two distinct series of unique Monoprints and two Limited Edition print series. After spending time among the archives of Cahiers d’Art, Rosa Barba drew inspiration from the original copper printing plates featuring

Evoking a Space Beyond Cinema

The exhibition features Aggregate States of Matters (2019), a film shot in the Peruvian Andes with the support of proyectoamil, in addition to a selection of her recent work. In 2002, Rosa Barba had one of her first exhibitions at the Sala Luis Miro-Quesada Garland in Miraflores (Lima) which started her enduring connection with Peru. During that visit Barba travelled extensively throughout the cou

Comparing terrestrial laser scanning (TLS) and satellite imagery for estimating carbon stocks in trees of a semi-arid savannah

Due to the intensifying impacts of climate change, accurate estimation of global carbon stocks is crucial, with aboveground vegetation biomass representing a significant carbon reservoir. Savannahs, which cover approximately 50% of the African continent, play a vital role in carbon storage, as trees within these ecosystems contribute substantially to the continent’s total carbon stocks. Estimating

Flood Risk Assessment for the Kävlinge River for Present and Future Climate Scenarios using HEC-RAS Rain-on-Grid

Extrema klimathändelser, såsom betydande översvämningar, utgör en risk för naturkatastrofer. På grund av klimatförändringarnas effekter förväntas södra Sverige få fler betydande regnväder som kan orsaka översvämningar i allt högre grad med mängden utsläpp. I denna studie undersöks dagens och framtidens översvämningsrisk i ett litet område i denna region, inom Kävlinges avrinningsområde. I det framExtreme climate events, such as significant flooding, pose a natural disaster risk. Due to climate change effects, the southern region of Sweden is anticipated to receive more significant rainstorms that could cause flooding increasingly with the quantity of emissions. This study examines the present-day and future climate’s flooding risk in a small area in this region, within the Kävlinge Watersh

Voice Engine & Hear, There Where the Echoes Are

Rosa Barba takes the components of cinema apart, giving each element a position in space and then starts playing with them. Designed as a promenade through the gallery, teeming with memories, the work offers a sensory experience that is further reinforced and enlivened with sound recordings of the vocal and musical performances.

The origin of the H αline profiles in simulated disc galaxies

Observations of ionized H αgas in high-redshift disc galaxies have ubiquitously found significant line broadening, σH α∼10 -100 km s-1 . To understand whether this broadening reflects gas turbulence within the interstellar medium (ISM) of galactic discs, or arises from out-of-plane emission in mass-loaded outflows, we perform radiation hydrodynamic simulations of isolated Milky Way-mass disc galax

Breast cancer hormone receptor levels and benefit from adjuvant tamoxifen in a randomized trial with long-term follow-up

BACKGROUND: Hormone receptor positivity predicts benefit from endocrine therapy but the knowledge about the long-term survival of patients with different tumor receptor levels is limited. In this study, we describe the 25 years outcome of tamoxifen (TAM) treated patients.PATIENTS AND METHODS: Between 1983 and 1992, a total of 4,610 postmenopausal patients with early-stage breast cancer were random

Prediction of High Nodal Burden in Patients With Sentinel Node-Positive Luminal ERBB2-Negative Breast Cancer

IMPORTANCE: In patients with clinically node-negative (cN0) breast cancer and 1 or 2 sentinel lymph node (SLN) macrometastases, omitting completion axillary lymph node dissection (CALND) is standard. High nodal burden (≥4 axillary nodal metastases) is an indication for intensified treatment in luminal breast cancer; hence, abstaining from CALND may result in undertreatment.OBJECTIVE: To develop a

Signal amplification in molecular sensing by imprinted polymers

In the field of sensing, the development of sensors with high sensitivity, accuracy, selectivity, sustainability, simplicity, and low cost remains a key focus. Over the past decades, optical and electrochemical sensors based on molecular imprinting techniques have garnered significant attention due to the above advantages. Molecular imprinting technology utilizes molecularly imprinted polymers (MI

Vestibular stimulation for promoting development and preventing morbidity in preterm infants

Objectives: This is a protocol for a Cochrane Review (intervention). The objectives are as follows:. To assess the benefits and harms of vestibular stimulation compared to standard care or non-vestibular stimulation for physical and neurological development in preterm infants. To assess whether the effects of vestibular stimulation differ according to gestational age at birth; the type, frequency,