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Most carcinomas are prone to metastasize despite successful treatment of the primary tumor. One way to address this clinical challenge may be targeted therapy with α-emitting radionuclides such as astatine-211 (211At). Radioimmunotherapy utilizing α-particle emitting radionuclides is considered especially suitable for the treatment of small cell clusters and single cells, although lesions of diffe
Popular Abstract in Swedish POPULÄRVETENSKAPLIG SAMMANFATTNING Halsbränna och sura uppstötningar är vanliga åkommor i den svenska befolkningen där upp till 20 procent av de tillfrågade uppger sig ha besvär av dessa symtom varje vecka. Både halsbränna och sura uppstötningar anses vara symtom på att magsäcksinnehåll flödar tillbaka upp genom övre magmunnen till matstrupen sk gastroesofageal reflux.This thesis investigates several aspects on gastroesophageal reflux disease (GERD) and associated complications as Barrett’s esophagus and esophageal adenocarcinoma. I. To clarify the natural course of GERD, a pH-metry verified cohort was re-evaluated after 20 years. The course of GERD may well be progressive. A statement based on the evidence that reflux induced complications as esophagitis and
The bit-error rate of a 60 GHz wireless impulse radio link is investigated at a bit-rate of 4 Gbps using on-off keying. The measurement results show that it is possible to have a BER below 10(-12), and the measured BER vs. E-b/N-o is approximately 1 dB from the theoretical value. The reliability of the wideband 60 GHz wavelet generator is furthermore confirmed by studying the number of faulty wave
This study has investigated the impact of presynaptic factors on the development of dyskinesia during chronic L-DOPA treatment in a rat model of Parkinson’s disease (PD). The mechanisms causing dyskinesia are not completely understood but have been proposed to involve changes in gene and protein expression in striatal neurons, which are the main target of dopamine (DA) projections from the substan
Oxyfuel process is a promising technique for carbon capture and storage, and a new application of perovskite-type oxide is as oxygen carrier for CO2 capture in oxy-fuel combustion system. This study proposed a novelty process and an optimization study on the synthesis of the BaCoO3-delta perovskite powders using microwave-assisted EDTA method. OA(16) (4(5)) orthogonal experiments were employed to
Water vapor sorption isotherms are essential data in models to predict the service life of cement based structures. This study investigates the influence of water to binder ratio (0.4, 0.5 and 0.6), and the presence of two SCMs (70% slag and 10% silica fume) on sorption isotherms, both in the hygroscopic and in the super-hygroscopic relative humidity (RH) ranges. In the present paper desorption is
The performance of traditional continuous-time (CT) delta-sigma analog-to-digital converters (ADCs) is limited by their large sensitivity to feedback pulse-width variations caused by clock jitter in their feedback digital-to-analog converters (DACs). To mitigate that effect, we propose a modified switched-capacitor (SC) feedback DAC technique, with a variable switched series resistor (SR). The arc
This review provides a comprehensive account of what is known presently about Amazonian aerosol particles and concludes by formulating outlook and priorities for further research. The review is organized to follow the life cycle of Amazonian aerosol particles. It begins with a discussion of the primary and secondary sources relevant to the Amazonian particle burden, followed by a presentation of t
Abstract in UndeterminedRejections of infants among non-human primates occasionally occur in the wild as well as in captive settings. Controlled adoptions of orphans and introductions of individuals into new groups are therefore sometimes necessary in captivity. Consequently, behavioral research on integration procedures and on the acceptance of infants by adoptive mothers is much needed. In this
With a centre-of-mass energy of 5.5 TeV per nucleon, Pb–Pb collisions at the LHC are expected to provide a copious yield of heavy quarks. In this paper, an overview of the ALICE perspectives for heavy flavour physics will be presented. The ALICE experiment will detect quarkonia both in the e+e− and in the μ+μ− decay channels. Open heavy flavoured hadrons will be studied in the semileptonic decay c
Many studies have found close relationships between accessibility and various socio-economic indicators. Yet, since accessibility tends to have differentiated effects, both socially and spatially, there is a need for a model which allows for a disaggregated analysis of accessibility. The model should be possible to use in areas where road network data is incomplete. In this paper such an accessibi
Dying is inescapable yet remains a neglected issue in modern health care. The research question in this study was "what is going on in the field of dying today?" What emerged was to eventually present a grounded theory of control of dying focusing specifically on how people react in relation to issues about euthanasia and physician-assisted suicide (PAS).
The J/ψ is considered to be among the most important probes for the deconfined quark–gluon plasma (QGP) created by relativistic heavy-ion collisions. While the J/ψ is thought to dissociate in the QGP by Debye color screening, there are competing effects from cold nuclear matter (CNM), feed-downs from excited charmonia (χc and ψ') and bottom quarks, and regeneration from uncorrelated charm quarks.
Despite recent attempts to relax the phase-noise demands on voltage-controlled oscillators (VCOs) for cellular communications [1], mainstream radios require harmonic VCOs capable of a very low phase noise with moderate power consumption, associated to a large tuning range (TR) and a high insensitivity to interfering signals. Ideally, the TR should be in excess of one octave, since this allows the
Although solitary bees are considered to play key roles in ecosystem functions, surprisingly few studies have explored their population dynamics. We investigated the population dynamics of a rare, declining, solitary bee (Andrena humilis) in a landscape of 80 km 2 in southern Sweden from 2003 to 2011. Only one population was persistent throughout all years studied; most likely this population supp
