Background: Cystic Fibrosis is a pleiotropic disease in humans with primary morbidity and mortality associated with a lung disease phenotype. However, knockout in the mouse of cftr, the gene whose mutant alleles are responsible for cystic fibrosis, has previously failed to produce a readily, quantifiable lung phenotype. Results: Using measurements of pulmonary mechanics, a definitive lung phenotyp

The conflicts concerning the preservation or destruction of the deserted church of Mårup in Denmark is followed from the the moment in 1928, when the church became redundant, untill 2004. The protection of the church is in conflict with the protection of the eroding cliff, the church as a symbol in conflict with the church as a source material, and the local people in conflict with central authori

The affinity and enantioselectivity have been determined for designed propranolol derivatives as ligands for Cel7A by capillary electrophoresis (CE) at pH 7.0. These results have been compared to measurements at pH 5.0. In agreement with previous studies, the affinity increased at the higher pH. However, the affinity was not as dependent of the ligand structure at pH 7.0 as at pH 5.0, and the sele

Context: The impact of long-term GH replacement on cerebrovascular and cardiovascular diseases and diabetes mellitus in hypopituitary patients is unknown. Objective: The incidence of nonfatal stroke and cardiac events, and prevalence of type 2 diabetes mellitus ( T2D) and cardioprotective medication were compared between cohorts of GH-deficient (GHD) patients and population controls. Design and Pa

I describe briefly the status of the ARIADNE program implementing the Dipole Cascade Model and comment both on its performance at HERA, and the uncertainties relating to the extrapolation to LHC energies.

Human papillomavirus (HPV) type 16 is the major cause of cervical carcinoma, the incidence of which is decreasing in western countries. In Finland the incidence is, however, increasing in women aged

he aim of this study was to explore aspects of the meaning of home as experienced by very old single-living people in Sweden. A grounded theory approach was used, and interviews were conducted with 40 men and women aged 80-89. The findings indicate that home has a central place in the lives of very old people because it is where they live and spend so much time. The significance of the home is bas

A third order conservative reconstruction, in the context of finite volume schemes for hyperbolic conservation laws, is constructed based on logarithmic functions. This logarithmic method reconstructs without the use of a limiter, any preprocessing of input data, special treatments for local extrema, or shock solutions. Also the method is local in the sense that data from only the nearest neighbor