The transcription factor PAX5 is a critical regulator of B-cell commitment and development. Although normally not expressed in myeloid progenitors, PAX5 has recently been shown to be frequently expressed in myeloid malignancies and to suppress expression of myeloid differentiation genes, compatible with an effect on the differentiation or maintenance of myeloid progenitors. However, previous studi

Background: Vibration to the head or neck excites vestibular and neck muscle spindle afferents. Can such vibrations improve the sensitivity of the subjective visual horizontal (SVH) test to chronic unilateral deficit of the vestibular system? Design: Controlled experimental study. Setting: Tertiary referral center. Patients and Controls: Thirteen healthy subjects and 23 patients with chronic unila

It has been suggested that nestlings use begging to increase their share of parental resources at the expense of current or future siblings. There is ample evidence that siblings compete over food with nestmates by begging, but only short-term effects of begging on parental provisioning rates have been shown. In this study, we use a new experimental design to demonstrate that pied flycatcher (Fice

Abstract in UndeterminedBackground: The long-term experience of living with peripheral arterial disease (PAD) and the durability of improvements after revascularisation are sparsely described in the literature. The primary goals of medical treatment and nursing care for PAD are to provide relief of symptoms, improve quality of life, and prevent the progression of arterial disease and cardiovascula

The prediction of impurity peaking in future fusion devices such as ITER necessitates the study of the dependence on Z of the impurity transport in present devices. In this paper we describe a novel technique to determine the transport of impurities with different atomic numbers independently. A technique has been developed that allows simultaneously the measurement of the transport of Ne and Ar i

It is plausible that polymorph isms in the estrogen receptor alpha and beta genes (ESR1 and ESR2) may modulate the association between enterolactone and breast cancer. Seven polymorph isms in ESR1 (rs827422, rs1709184, rs2347867, rs3020328, rs72207, rs2982896, and rs2234693) and 5 polymorphisms in ESR2 (rs915057, rs1269056, rs1256033, rs3020450, and rs3020443) were selected. The risk of breast can

A selective and sensitive method is presented for biogenic amines (BA) determination. The novelty consists in coupling a highly selective electrochemical biosensor to a weak acid cation-exchange column for online detection of amines. A bienzyme design, based on a recently isolated amine oxidase from grass pea and commercial horseradish peroxidase, was used for the biosensor construction. The enzym

A continuous supermacroporous monolithic chromatographic matrix has been characterized using a capillary model, experimental breakthrough curves, and pressure drop experiments. The model describes the convective flow and its dispersive mixing effects, mass transfer resistance, pore size distribution, and the adsorption behavior of the monolithic matrix. It is possible to determine an effective por

Hordeins from H. vulgare, H. murinum, H. pusillum, H. bulbosum, and H. brevisubulatum were probed with five monoclonal antibodies raised against different hordein polypeptides from Hordeum vulgare cv. ‘Bomi’. The response pattern differed widely among species. One of the antibodies, CMpBChorl, was found to react with hordein from every tested species, and all of the antibodies reacted with at leas

Genetic diversity in eight populations of Sphagnum capillfolium from different Bulgarian mountains was investigated by means of isozyme electrophoresis. High levels of allelic diversity were found (H-s = 0.119), comparable to earlier estimates for northern European populations (H-s = 0.116). Strong differentiation among populations and a low number of widespread genotypes suggest a high degree of

Allergic contact dermatitis to rubber is caused by residues of chemicals used in manufacturing a rubber product. Several different additives are used to achieve a final product of the desired characteristics. Accelerators such as thiurams, dithiocarbamates, and mercaptobenzothiazoles are often among the additives responsible for allergic reactions recognized by dermatologists. The chemistry of the

Two experiments examined the realism in the confidence of 8-9-year-olds,12-13-year-olds and adults in their free recall and answers to focused questions after viewing a short videoclip. A different videoclip was shown in each experiment and the focused questions differed in difficulty. In both experiments the youngest age group, in contrast to the two other age groups, showed no overconfidence in

Effectors of the innate immune system, the anti-bacterial peptides, have pivotal roles in preventing infection at epithelial surfaces. Here we show that proteinases of the significant human pathogens Pseudomonas aeruginosa, Enterococcus faecalis, Proteus mirabilis and Streptococcus pyogenes, degrade the antibacterial peptide LL-37. Analysis by mass spectrometry of fragments generated by P. aerugin

The first identification of a sex pheromone of a pine sawfly (Hymenoptera, Diprionidae) dates back almost thirty years. Since then, female-produced pheromones of over twenty diprionid species have been investigated by solvent extraction followed by separation and identification. However, no study has shown what the females actually release. Collection of airborne compounds using absorbtion on char

Mutations in type 3 repeats of cartilage oligomeric matrix protein (COMP) cause two skeletal dysplasias, pseudoachondroplasia (PSACH) and multiple epiphyseal dysplasia (MED). We expressed recombinant wild-type COMP that showed structural and functional properties identical to COMP isolated from cartilage. A fragment encompassing the eight type 3 repeats binds 14 calcium ions with moderate affinity

Of patients with in-hospital cardiac arrest, those with pulseless electrical activity ( PEA) have the worst outcome. Especially in these patients effective chest compressions according to the guidelines may be the key strategy to improve survival. Recently, a novel automatic mechanical chest compression device (LUCAS-CPR) has been shown to ensure effective continuous compressions without interrupt