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Intra-droplet acoustic particle focusing : simulations and experimental observations

The aim of this paper is to study resonance conditions for acoustic particle focusing inside droplets in two-phase microfluidic systems. A bulk acoustic wave microfluidic chip was designed and fabricated for focusing microparticles inside aqueous droplets (plugs) surrounded by a continuous oil phase in a 380-μm-wide channel. The quality of the acoustic particle focusing was investigated by conside

Mechanisms of Crystalloid versus Colloid Osmosis across the Peritoneal Membrane

Background Osmosis drives transcapillary ultrafiltration and water removal in patients treated with peritoneal dialysis. Crystalloid osmosis, typically induced by glucose, relies on dialysate tonicity and occurs through endothelial aquaporin-1 water channels and interendothelial clefts. In contrast, the mechanisms mediating water flow driven by colloidal agents, such as icodextrin, and combination

Imaging the Right Heart-Pulmonary Circulation Unit : The Role of MRI and Computed Tomography

The different components of the right heart pulmonary circulation unit can be investigated by MRI and computed tomography. MRI has clear advantages over echocardiography for accurate definition of right heart function and structure and to derive functional information regarding the pulmonary vasculature. Computed tomography is superior for the assessment of parenchymal and vascular pathologies of

The Right Heart International Network (RIGHT-NET) : Rationale, Objectives, Methodology, and Clinical Implications

The Right Heart International Network is a multicenter international study aiming to prospectively collect exercise Doppler echocardiography tests of the right heart pulmonary circulation unit (RHPCU) in large cohorts of healthy subjects, elite athletes, and individuals at risk of or with overt pulmonary hypertension. It is going to provide standardization of exercise stress echocardiography of RH

The Merry-Go-Round of Meetings : Embracing Meetings in a Swedish Youth Care Project

Modern society has been called “a society of organizations,” and meetings are considered indispensable. However, a recurring cultural theme in contemporary working life is complaints about excessive and time-consuming meetings. The present article analyzes a contrasting case concerning a Swedish youth care project that employed a set of “coordinators” to maintain close contact with young people an

Female-Specific Association Between Variants on Chromosome 9 and Self-Reported Diagnosis of Irritable Bowel Syndrome

Background & Aims: Genetic factors are believed to affect risk for irritable bowel syndrome (IBS), but there have been no sufficiently powered and adequately sized studies. To identify DNA variants associated with IBS risk, we performed a genome-wide association study (GWAS) of the large UK Biobank population-based cohort, which includes genotype and health data from 500,000 participants. Meth

Artificial recharge efficiency assessment by soil water balance and modelling approaches in a multi-layered vadose zone in a dry region

To assess recharge through floodwater spreading, three wells, approx. 30 m deep, were dug in a 35-year-old basin in southern Iran. Hydraulic parameters of the layers were measured. One well was equipped with pre-calibrated time domain reflectometry (TDR) sensors. The soil moisture was measured continuously before and after events. Rainfall, ponding depth and the duration of the flooding events wer

Prevention Models of Childhood Obesity in Sweden

The impact of childhood obesity on the Swedish Health Care system is described. Childhood Obesity and Diabetes Type 2 is increasing for the last 10 years, but not Diabetes Type 1. Thus, prevention is needed. How to define prevention of obesity? Could treatment of childhood obesity be regarded as prevention of adult obesity? Of course it could, but we are lacking a long term follow-up from childhoo

Benzylpenicillin versus wide-spectrum beta-lactam antibiotics as empirical treatment of Haemophilus influenzae-associated lower respiratory tract infections in adults; a retrospective propensity score-matched study

There is consensus that definitive therapy for infections with H. influenzae should include antimicrobial agents with clinical breakpoints against the bacterium. In Scandinavia, benzylpenicillin is the recommended empirical treatment for community-acquired pneumonia (CAP) except in very severe cases. However, the effect of benzylpenicillin on H. influenzae infections has been debated. The aim of t

Age-dependent alpha-synuclein accumulation and aggregation in the colon of a transgenic mouse model of Parkinson's disease

Background: Parkinson's disease (PD) is one of the most common neurodegenerative diseases, neuropathologically characterized by misfolded protein aggregation, called Lewy bodies and Lewy neurites. PD is a slow-progressive disease with colonic dysfunction appearing in the prodromal stage and lasting throughout the course of the disease. Methods: In order to study PD pathology in the colon, we exami

Bosonic Szilard engine assisted by Feshbach resonances

It was recently found that the information-to-work conversion in a quantum Szilard engine can be increased by using a working medium of bosons with attractive interactions. In the original scheme, the work output depends on the insertion and removal position of an impenetrable barrier that acts like a piston, separating the chambers of the engine. Here, we show that the barrier removal process can

Wetlands for wastewater treatment and subsequent recycling of treated effluent : a review

Due to water scarcity challenges around the world, it is essential to think about non-conventional water resources to address the increased demand in clean freshwater. Environmental and public health problems may result from insufficient provision of sanitation and wastewater disposal facilities. Because of this, wastewater treatment and recycling methods will be vital to provide sufficient freshw

Femtosecond laser-induced cyano chemiluminescence in methane-seeded nitrogen gas flows for near-wall velocimetry

We demonstrate a velocimetric technique based on femtosecond laser-induced cyano (CN) chemiluminescence (FLICC). High intensity emission originated from CN(B-X) fluorescence was observed in filaments generated by focusing a femtosecond laser in methane-seeded nitrogen gas flows. The emission is strong and can last for hundreds of microseconds with a proper methane concentration. FLICC was adopted

Importance of standardizing timing of hematocrit measurement when using cardiovascular magnetic resonance to calculate myocardial extracellular volume (ECV) based on pre- and post-contrast T1 mapping

Background: Cardiovascular magnetic resonance (CMR) can be used to calculate myocardial extracellular volume fraction (ECV) by relating the longitudinal relaxation rate in blood and myocardium before and after contrast-injection to hematocrit (Hct) in blood. Hematocrit is known to vary with body posture, which could affect the calculations of ECV. The aim of this study was to test the hypothesis t

Inter-rater agreement of the Quality of Life-Alzheimer's Disease (QoL-AD) self-rating and proxy rating scale : Secondary analysis of RightTimePlaceCare data

Background: To assess the quality of life of people with dementia, measures are required for self-rating by the person with dementia, and for proxy rating by others. The Quality of Life in Alzheimer's Disease scale (QoL-AD) is available in two versions, QoL-AD-SR (self-rating) and QoL-AD-PR (proxy rating). The aim of our study was to analyse the inter-rater agreement between self- and proxy rating

The Efficiency Index (EFFi), based on volumetric capnography, may allow for simple diagnosis and grading of COPD

Background: Spirometry, the main tool for diagnosis and follow-up of COPD, incompletely describes the disease. Based on volumetric capnography (VCap), an index was developed for the diagnosis and grading of COPD, aimed as a complement or alternative to spirometry. Methods: Nine non-smokers, 10 smokers/former smokers without COPD and 54 smokers/ former smokers with COPD were included in the study.

The Molecular Basis for Inhibition of Stemlike Cancer Cells by Salinomycin

Tumors are phenotypically heterogeneous and include subpopulations of cancer cells with stemlike properties. The natural product salinomycin, a K+-selective ionophore, was recently found to exert selectivity against such cancer stem cells. This selective effect is thought to be due to inhibition of the Wnt signaling pathway, but the mechanistic basis remains unclear. Here, we develop a functionall

Implementation of observed sky-view factor in a mesoscale model for sensitivity studies of the urban meteorology

The sky view factor (SVF) is an important radiometric parameter for assessing the canopy energy budget of urban areas. There are several methods to determine the SVF observationally. The most common is taking a photo with a digital camera equipped with a fish-eye lens and then converting ratio of sky area to canopy area into SVF. However, most urban canopy models use this variable as derived from

Familial Risks of Glaucoma in the Population of Sweden

Background: Glaucoma has a familial component but detailed data on the modification of familial risks are lacking. The aim of the study was to determine detailed familial risks for medically diagnosed glaucoma based on nationwide hospital and population records. Methods: Subjects were obtained from the Multigeneration Register, contains the Swedish population in families, and glaucoma patients wer