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Purpose: Some 10% of familial adenomatous polyposis (FAP) and 80% of attenuated polyposis (AFAP) cases remain molecularly unexplained. We scrutinized such cases by exome-wide and targeted methods to search for novel susceptibility genes. Methods: Exome sequencing was conducted on 40 unexplained (mainly sporadic) cases with FAP or AFAP from Finland. The DNA mismatch repair (MMR) gene MLH3 (MutL Hom
Heteroleptic iron based complexes bearing the 2,6-bis[3-(2,6-diisopropylphenyl)imidazol-2-ylidene]pyridine motif and a polypridine ligand have been synthesized and characterized in their ground and excited state. This series of complexes includes a first example of a hetero-bimetallic complex connecting an iron N-heterocyclic carbene photosensitizer with a cobalt dimethylglyoxime fragment. Focus i
BackgroundThe forest biorefinery plays an important part in the evolving circular bioeconomy due to its capacity to produce a portfolio of bio-based and sustainable fuels, chemicals, and materials. To tap into its true potential, more efficient and environmentally benign methods are needed to fractionate woody biomass into its main components (cellulose, hemicellulose, and lignin) without reducing
The clustering of different types of B-cell malignancies in families raises the possibility of shared aetiology. To examine this, we performed cross-trait linkage disequilibrium (LD)-score regression of multiple myeloma (MM) and chronic lymphocytic leukaemia (CLL) genome-wide association study (GWAS) data sets, totalling 11,734 cases and 29,468 controls. A significant genetic correlation between t
Length-of-stay (LOS) is a key parameter in destination management that determines the number of guest nights relative to arrival numbers, with concomitant repercussions for revenue generation and other performance indicators. This article investigates the development of LOS for 32 destinations in developed and emerging economies as well as Small Islands and Developing States (SIDS). The analysis i
The Paris Climate Agreement is based on pledges from 195 countries to substantially reduce emissions of greenhouse gases (GHG) to prevent dangerous climate change. The tourism sector has likewise pledged to reduce its GHG emissions (−70% by 2050); however, current emission trends would result in a tripling in the same timeframe. In order to understand how the sector understands the decarbonisation
Hydrotropic extraction (HEX) is a method for the delignification of lignocellulose that has been given increasing amounts of attention during the last couple of years. A hydrotrope is an amphiphilic substance, which, in high enough concentrations, can improve solubility of otherwise poorly soluble substances in water. The most commonly used substance for HEX-delignification is sodium xylenesulfona
The forest industry is one of Sweden’s most important business areas. As the use of paper is declining the need for this sector to find other alternatives is increasing. An attractive option to meet this demand is the establishment of forest biorefineries. However, economically suitable pretreatment methods for woody biomass, which minimize degradation of the structural carbohydrates and allow the
Background: Frailty is considered highly prevalent among the aging population. Fruit and vegetable intake is associated with positive health outcomes across the life-span; however, the relationship with health benefits among older adults has received little attention. Aim: The aim was to examine if a relationship exists between meal frequency or frequency of vegetable intake and the development of
This paper explores trade connections – or the lack of such – between copperworks and copper processing plants in the Oldenburg Monarchy in the eighteenth century. Domestic customs areas, high tariffs on raw material export and import bans sought to encourage domestic copper and brass goods production of Norwegian copper raw material, however this was only realised halfway. The raw material from N
The 2013 reform of the Common Agricultural Policy (CAP) introduced compulsory ‘greening’ measures with the goal to mitigate environmental degradation caused by intensive agriculture. This paper aims to investigate how the implementation of the Ecological Focus Areas (EFA) obligation will affect regional agricultural development, the economic performance of farms and land use (including choices of
The demand for energy in the world is increasing steadily. As the standard of living for people in the developing countries is increasing so is the net energy use per capita. The main contributor to the energy consumption is the use of fossil fuels, which is also the major emission source for carbon dioxide. Carbon dioxide is in turn one of the most significant greenhouse gases and will enhance te
ALK mutations occur in 10% of primary neuroblastomas and represent a major target for precision treatment. In combination with MYCN amplification, ALK mutations infer an ultra-high-risk phenotype resulting in very poor patient prognosis. To open up opportunities for future precision drugging, a deeper understanding of the molecular consequences of constitutive ALK signaling and its relationship to
Pancreatic cancer (PC) has an exceptionally low survival rate and primary prevention strategies are limited. Folate plays an important role in one-carbon metabolism and has been associated with the risk of several cancers, but not consistently with PC risk. We aimed to investigate the association between dietary folate intake and PC risk, using the standardised folate database across 10 European c
Den senaste reformen av EU:s gemensamma jordbrukspolitik (CAP) sjösattes 2015 med avsikten att göra det europeiska jordbruket mer konkurrenskraftigt och mer hållbart. Syftet med den här rapporten är att analysera vilka effekter reformen kan väntas få på svenskt jordbruk på områdena konkurrenskraft och miljö, för att undersöka om målen med reformen uppfylls eller ej. Analysen bygger på simuleringar
