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The development of biotechnological products is becoming more and more expensive. One type of protein attracting a great deal of attention in the biopharmaceutical industry is antibodies, which was used in this work. The cost of producing antibodies is, however, high, mainly due to the downstream processing, which constitutes 50–80% of the total cost. This work describes model-based methods to des

The concept of personality is scrutinized as used both in common parlance and in more sophisticated frames of reference. Current multidimensional models are criticized for their reliance on self-descriptive questionnaires and for their lack of a hierarchical dimension, differentiating more or less decisive determinants of behavior. A possible psychoanalytic model is viewed with more benevolence bu

Modelling of 2D resistivity imaging was done in order to understand the principle resolution of the technique in different geological situations, and for assessing the behaviour of the interpretation methods under controlled circumstances. The Wenner array was used throughout. The results show that the 1D approximation only provides reasonable results in environments with very gradual lateral resi

We propose and investigate a unifying class of sparse random graph models, based on a hidden coloring of edge-vertex incidences, extending an existing approach, random graphs with a given degree distribution, in a way that admits a nontrivial correlation structure in the resulting graphs. The approach unifies a number of existing random graph ensembles within a common general formalism, and allows

The article discusses the sociocultural dimensions to the Chinese courtesy titles 'nüshi' (ladies) and 'xiansheng' (gentlemen).

This paper reflects how anti-islanding protection has developed with increasing DG penetration. Starting from a local issue it has developed to possibly affect system security. The focus here is on how islanding detection methods and anti-islanding protection settings relate to distribution level and TSO requirements. It is confirmed using field measurements and simulations that the most common pa

The reaction of [Co2{μ-C2(CO2Me)2}(CO)6] with the ligand diphenyl-2-thienylphosphine, PPh2(C4H3S), yields the complexes [Co2{μ-C2(CO2Me)2}(CO)5{PPh2(C4H3S)}] (1) and [Co2{μ-C2(CO2Me)2}(CO)4{PPh2(C4H3S)}2] (2). The related complex [Co3(μ3CMe)(CO)9] reacts with the same ligand to give [Co3(μ3-CMe)(CO)8{PPh2(C4H3S)}] (3) and [Co3(μ3-CMe)(CO)7{PPh2(C4H3S))2] (4). Thermolysis of 1 at 80°C leads to part

Antigenic variation of surface proteins allows microorganisms to evade the immune system of the infected host. This phenomenon represents an apparent paradox, because the variable protein must retain an important function, while its antigenic properties vary extensively. The surface associated M protein of Streptococcus pyogenes, a common human pathogen, exhibits antigenic variation due to an N-te

Background Because of current cost restrictions, we studied the effect of a shorter hospital stay on function, pain and quality of life (QOL) after total hip replacement (THR). Patients and methods 50 patients from two hospitals were randomized into a study group (SG) of 27 patients receiving preoperative and postoperative education programs, as well as home visits from an outpatient team, and a c

Most patients referred to physiotherapy with low back pain are without a precise medical diagnosis. Identification of subgroups of non-specific low back pain patients may improve clinical outcomes and research efficiency. A pathoanatomic classification system has been developed, classifying patients with non-specific low back pain into 12 different syndromes and three subcategories based on histor

Essay regarding current debates in Sweden about the various functions of art criticism in relation to the public sphere. Language: Swedish.

Play audiometry is part of the general developmental screening covering 4-year-old children in the city of Malmo (Sweden). In an open study, 10% of the cohort was tested with transient-evoked otoacoustic emissions (TEOAEs), using the ILO88 system. The aim was to reveal a hearing loss exceeding 25 dB HL in 4-year-old children. As the first step in determining whether emissions can be used as an eff

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