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We have identified a new cyclic-nucleotide phosphodiesterase isoform, PDE3A, and cloned its cDNA from cultured aortic myocytes. The nucleotide sequence of its coding region is similar to that of the previously cloned myocardial isoform except for the absence of the initial 300-400 nt that are present in the latter, as confirmed by reverse-transcriptase-mediated PCR, 5' rapid amplification of cDNA

Sedan våren 2005 har en grupp tonåriga pojkar inom habiliteringen i Region Skåne engagerats i en till synes udda fritidsaktivitet. Tillsammans med medlemmar i en motorförening och en fritidsförening samlas de en kväll i veckan på en motorgård i Väla utanför Helsingborg för att meka med en gammal bil. ”Projekt Raggarbil” har på kort tid blivit mycket populärt bland ungdomarna, deras föräldrar och

1. Stocking of piscivores in shallow, eutrophicated lakes to reduce cyprinid densities is a common approach in lake restorations. Young-of-the-year (YOY) pike Esox lucius are frequently used to reduce cyprinid densities, but their effectiveness is equivocal. This study uses a simple model to assess the efficacy of pike stocking as a lake restoration tool. 2. The model evaluates YOY pike consumptio

Cell culture models were used to study the effects of long-term ethanol exposure on neuronal cells. Effects on phospholipase C and phospholipase D mediated signal transduction were investigated by assaying receptor-binding, G protein function, activities of lipases, formation of second messengers and c-fos mRNA. The signal transduction cascades displayed abnormal activities from 2 to 7 days of exp

Ground-based FTIR-measurements have been performed at the NDSC (Network for Detection of Stratospheric Change) station on Spitsbergen ((79)degrees N, 12 degrees E). We have investigated several well isolated absorption lines of isotopically heavy O-3 in the 10 mu m region that allowed us to quantify their natural abundances in the arctic atmosphere for the period April 1994 to August 1995, On the

In Sweden application of granulated wood ash has been suggested as a method to supplement nutrient loss resulting from harvesting of forest residues for bioenergy production. Mycelia of two ectomycorrhizal fungi Piloderma sp.I and Ha-96-3. were commonly found to colonise ash granules in a wood ash fertilised spruce forest. Thirty-eight fungal isolates were selected from 10 taxa to investigate the

With material from a Swedish study of the utilization of social research in city welfare agencies, the authors advocate a sociological analysis of the utilization contexts where use of research takes place. The bases of compliance in the organization and the position of the agencies in regard to conflicts in social welfare politics are shown to have great importance for the way organizations use a

High-voltage outdoor insulators made from silicone rubber are sometimes reported to be colonised by microorganisms. When the hydrophobic polymeric surface is covered by a hydrophilic biofilm, the electrical properties of the insulator are altered. In this work, mixed biofilms, similar to those formed on the surfaces of polymeric insulators in the field, were successfully grown on five types of sil

This study aimed to compare the duration of protection against exercise-induced bronchoconstriction (EIB) after inhalation of formoterol (Oxis) Turbuhaler with that of terbutaline Turbuhaler and placebo Turbuhaler in asthmatic patients treated regularly with formoterol Turbuhaler 9 microg b.i.d. and inhaled steroids. The study. performed at three centres (Goteborg and Lund, Sweden, and Trondheim,

Purpose: Bladder outlet obstruction leads to bladder enlargement and subsequent decreases in contractile function in vivo and in vitro. We determined whether there were regional differences in bladder wall properties and in vitro contractile responses after 2 weeks of bladder outlet obstruction. Materials and Methods: Male rabbits underwent cystometry. The bladder was then filled to 40 ml. and the