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Age at Menopause and the Risk of Stroke : Observational and Mendelian Randomization Analysis in 204 244 Postmenopausal Women

BACKGROUND: Observational studies have shown that women with an early menopause are at higher risk of stroke compared with women with a later menopause. However, associations with stroke subtypes are inconsistent, and the causality is unclear. METHODS AND RESULTS: We analyzed data of the UK Biobank and EPIC-CVD (European Prospective Investigation Into Cancer and Nutrition-Cardiovascular Diseases)

Sub-picosecond time-resolved cavity ring-down spectroscopy

This project aims to develop a time-resolved spectroscopic method that can resolve and characterize transient processes of optically thin samples. With that purpose, we investigate the combination of the pump-probe technique with cavity ring-down spectroscopy.

Places of Pain and Spaces of Silence : Re-Visiting a Bosnian Rape Camp

The relation between gender, silence, place and space is theorised in this article through an analysis of the former rape camp Vilina Vlas in Bosnia and Herzegovina. Combining a spatial perspective with narrative analysis, we dissect spatial practices and narrative silences that shape and reshape a particular place defined by gendered violence. We suggest that ‘places of pain’ and ‘spaces of silen

Head-to-head comparison of relative cerebral blood flow derived from dynamic [18F]florbetapir and [18F]flortaucipir PET in subjects with subjective cognitive decline

Background: Dynamic PET imaging studies provide accurate estimates of specific binding, but also measure the relative tracer delivery (R1), which is a proxy for relative cerebral blood flow (rCBF). Recently, studies suggested that R1 obtained from different tracers could be used interchangeably and is irrespective of target tissue. However, the similarities or differences of R1 obtained from diffe

Geometrical Magnetoresistance as a Tool for Carrier Mobility Extraction in InGaAs MOSFETs

In this work, we for the first time show that the geometrical magnetoresistance (gMR) effect is a powerful tool for extracting the carrier mobility in diffusive InGaAs near-surface quantum well MOSFETs. The technique shows excellent agreement to Hall effect measurements, confirming its validity. In addition, the gMR approach is less time-consuming, is suitable for measurements directly on the FETs

Structural-functional properties of direct-pathway striatal neurons at early and chronic stages of dopamine denervation

The dendritic arbour of striatal projection neurons (SPNs) is the primary anatomical site where dopamine and glutamate inputs to the basal ganglia functionally interact to control movement. These dendritic arbourisations undergo atrophic changes in Parkinson's disease. A reduction in the dendritic complexity of SPNs is found also in animal models with severe striatal dopamine denervation. Using 6-

Identification of bile acid-CoA:amino acid N-acyltransferase as the hepatic N-acyl taurine synthase for polyunsaturated fatty acids

N-acyl taurines (NATs) are bioactive lipids with emerging roles in glucose homeostasis and lipid metabolism. The acyl chains of hepatic and biliary NATs are enriched in polyunsaturated fatty acids (PUFAs). Dietary supplementation with a class of PUFAs, the omega-3 fatty acids, increases their cognate NATs in mice and humans. However, the synthesis pathway of the PUFA-containing NATs remains undisc

Coherent FDA Receiver and Joint Range-Space-Time Processing

When a target is masked by mainlobe clutter with the same Doppler frequency, it is difficult for conventional airborne radars to determine whether a target is present in a given observation using regular space-time adaptive processing techniques. Different from phased-array and multiple-input multiple-output (MIMO) arrays, frequency diverse arrays (FDAs) employ frequency offsets across the array e

The legal aspects of cruise ship passenger contracts

The purpose of this chapter is to discuss the legal issues relating to cruise ship passenger contracts, their nature and salient features, parties to the contract and their rights and obligations. Claims arising out of passenger carriage subject to applicable law and contracts containing standard terms and conditions are addressed. It is rare for passengers to examine the terms and conditions of t

Holistic management of patients with progressive pulmonary fibrosis

Progressive pulmonary fibrosis (PF) is a complex interstitial lung disease that impacts substantially on patients’ daily lives, requiring personalised and integrated care. We summarise the main needs of patients with PF and their caregivers, and suggest a supportive care approach. Individualised care, education, emotional and psychological support, specialised treatments, and better access to info

Genetic modification of inflammation- and clonal hematopoiesis-associated cardiovascular risk

Clonal hematopoiesis of indeterminate potential (CHIP) is associated with an increased risk of cardiovascular diseases (CVDs), putatively via inflammasome activation. We pursued an inflammatory gene modifier scan for CHIP-associated CVD risk among 424,651 UK Biobank participants. We identified CHIP using whole-exome sequencing data of blood DNA and modeled as a composite, considering all driver ge

Extending the cystatin C based EKFC-equation to children – validation results from Europe

Background: A new cystatin C based European Kidney Function Consortium (EKFCCysC) equation was recently developed for adults, using the same mathematical form as the previously published full age spectrum creatinine based EKFC-equation (EKFCCrea). In the present study the cystatin C based EKFC-equation is extended to children, by defining the appropriate cystatin C rescaling factor QCysC. Methods:

Marchantiana pyramus, M. ramulicola and Austroplaca thisbe (Teloschistaceae, lichenized Ascomycota) - three new twig lichens from southern Patagonia

Three twig-growing lichen species belonging to the family Teloschistaceae from southern Patagonia are described as new to science: Marchantiana pyramus sp. nov., with minute apothecia, orange due to dominant content of emodin, M. ramulicola sp. nov., with minute olive apothecia with dominant parietin and Austroplaca thisbe sp. nov., with clear yellow apothecia also with dominant parietin. Marchant

Autism in adult psychiatric out-patients : self-reported suicidal ideation, suicide attempts and non-suicidal self-injury

Background The prevalence of self-reported suicidal ideation, suicide attempts and non-suicidal self-injury (NSSI) remains unclear among adults with autism unrecognised in childhood who attend psychiatric services. Aims We aimed to estimate the prevalence of suicidal ideation, suicide attempts and NSSI; identify factors associated with suicide attempts and NSSI; and describe NSSI in this group. Me

Critical Step in the HCl Oxidation Reaction over Single-Crystalline CeO2-x(111) : Peroxo-Induced Site Change of Strongly Adsorbed Surface Chlorine

The catalytic oxidation of HCl by molecular oxygen (Deacon process) over ceria allows the recovery of molecular chlorine from the omnipresent HCl waste produced in various industrial processes. In previous density functional theory (DFT) model-calculations by Amrute et al. [ J. Catal. 2012, 286, 287−297.], it was proposed that the most critical reaction step in this process is the displacement of

Making hot Jupiters in stellar clusters - II. Efficient formation in binary systems

Observations suggested that the occurrence rate of hot Jupiters (HJs) in open clusters is largely consistent with the field (∼ 1 per cent) but in the binary-rich cluster M67, the rate is ∼ 5 per cent. How does the cluster environment boost HJ formation via the high-eccentricity tidal migration initiated by the extreme-amplitude von Zeipel–Lidov–Kozai (XZKL) mechanism forced by a companion star? Ou

Modular 3D printed platform for fluidically connected human brain organoid culture

Brain organoid technology has transformed both basic and applied biomedical research and paved the way for novel insights into developmental processes and disease states of the human brain. While the use of brain organoids has been rapidly growing in the past decade, the accompanying bioengineering and biofabrication solutions have remained scarce. As a result, most brain organoid protocols still

Cost-effectiveness analysis of bimekizumab for the treatment of active psoriatic arthritis in Sweden

Aims: To evaluate the cost-effectiveness of bimekizumab, an inhibitor of IL-17F and IL-17A, against biologic and targeted synthetic disease-modifying antirheumatic drugs (DMARD) for psoriatic arthritis (PsA) from the Swedish healthcare system perspective. Materials and methods: A Markov model was developed to simulate the clinical pathway of biologic [b] DMARD-naïve or tumor necrosis factor inhibi

Adjusted to reality? Mandate and functioning of the General Integral Commission of the Grande Tárcoles Rivershed in Costa Rica

The Grande de Tárcoles River in Costa Rica is one of the most polluted and degraded river basins in Central America. At the same time Costa Rica is a country internationally recognized for progressive environmental management. At least on paper, the country fosters sustainable river management in the form of integrated water resources management (IWRM). In the specific case of the Grande de Tárcol