Metastatic model of colon cancer in wild type and cysteinyl leukotriene receptor 1-/- B6 mice
Background: Colorectal cancer constitutes a major malignancy and the fourth major cause of deaths associated with cancer. Chronic inflammatory bowel diseases like Crohn´s disease and ulcerative colitis are one of the risk factors for the development of CRC. Cysteinyl leukotrienes (CysLTs) regulate both acute and chronic inflammation through lipophilic signaling. Upregulation of the expression of C
