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Raoul Wallenberg : Life and legacy

The Swedish diplomat Raoul Wallenberg was responsible for saving the lives of thousands of Jews in Budapest between 1944 and 1945. He is recognised by the Israeli state as one of the Righteous among the Nations. This book examines both Wallenberg's activities during the Holocaust and the ways posterity has remembered him. It explores secret Swedish diplomacy and how Wallenberg was transformed over

Förstföderskors upplevelser av delaktighet vid medicinska interventioner i samband med födsel på sjukhus.

Bakgrund: De senaste två decennierna har medicinska interventioner i samband med födsel ökat globalt. Förstföderskor har en högre incidens av medicinska interventioner än omföderskor. Vid rutinanvändning av medicinska interventioner ökar risken för att kvinnors delaktighet negligeras, vilket kan leda till en negativ förlossningsupplevelse. Det saknas studier om hur förstföderskor upplever delaktig

Epigenetics of the non-coding RNA nc886 across blood, adipose tissue and skeletal muscle in offspring exposed to diabetes in pregnancy

Background: Diabetes in pregnancy is associated with increased risk of long-term metabolic disease in the offspring, potentially mediated by in utero epigenetic variation. Previously, we identified multiple differentially methylated single CpG sites in offspring of women with gestational diabetes mellitus (GDM), but whether stretches of differentially methylated regions (DMRs) can also be identifi

ALG13-Congenital Disorder of Glycosylation (ALG13-CDG) : Updated clinical and molecular review and clinical management guidelines

ALG13-Congenital Disorder of Glycosylation (CDG), is a rare X-linked CDG caused by pathogenic variants in ALG13 (OMIM 300776) that affects the N-linked glycosylation pathway. Affected individuals present with a predominantly neurological manifestation during infancy. Epileptic spasms are a common presenting symptom of ALG13-CDG. Other common phenotypes include developmental delay, seizures, intell

An Early Evaluation Method of the Compatibility of Alternative Jet Fuels with Elastomer Seals

Klimatomställningar har gjorts inom de flesta delar av transportsektorn, som ofta pekas ut som boven i dramat när det kommer till utsläpp av koldioxid. Bilar som går på elektricitet är ett typiskt exempel. Denna omställning är svårare att göra när det gäller flygindustrin. Elektriska flygplan är inte realistiska just nu då batterierna hade behövt vara enorma. Fördelen med flytande bränslen är attThe aviation industry is a contributor to the global greenhouse gas emissions. Moving away from fossil-based fuels has proven to be more difficult than expected. One possibility for the aviation industry is the development of sustainable aviation fuels (SAFs), produced from renewable sources such as biomass and waste. Certain problems have been discovered with using SAFs, however. The fuels are us

Fixel-Based Analysis Reveals Tau-Related White Matter Changes in Early Stages of Alzheimer’s Disease

Several studies have shown white matter (WM) abnormalities in Alzheimer’s disease (AD) using diffusion tensor imaging (DTI). Nonetheless, robust characterization of WM changes has been challenging due to the methodological limitations of DTI. We applied fixel-based analyses (FBA) to examine microscopic differences in fiber density (FD) and macroscopic changes in fiber cross-section (FC) in early s

LGR6 is a prognostic biomarker for less differentiated tumors in lymph nodes of colon cancer patients

Introduction: The aim was to investigate whether the stem cell marker LGR6 has prognostic value in colon cancer, alone or in combination with the prognostic biomarkers CEA and CXCL16. Methods: LGR6 mRNA levels were determined in 370 half lymph nodes of 121 colon cancer patients. Ability to predict relapse after curative surgery was estimated by Kaplan-Meier survival model and Cox regression analys

Genome-wide investigation of persistence with methotrexate treatment in early rheumatoid arthritis

Objectives: To investigate the influence of genetic factors on persistence with treatment of early RA with MTX monotherapy. Methods: We conducted a genome-wide association study (GWAS) in a sample of 3902 Swedish early-RA patients initiating MTX in DMARD monotherapy as their first-ever DMARD. The outcome, short-and long-Term MTX treatment persistence, was defined as remaining on MTX at 1 and at 3

Dexmedetomidine for analgesia and sedation in newborn infants receiving mechanical ventilation

Background: Dexmedetomidine is a selective alpha-2 agonist with minimal impact on the haemodynamic profile. It is thought to be safer than morphine or stronger opioids, which are drugs currently used for analgesia and sedation in newborn infants. Dexmedetomidine is increasingly being used in children and infants despite not being licenced for analgesia in this group. Objectives: To determine the o

A thermodynamically consistent phase transformation model for multiphase alloys : application to Ti6Al4V in laser powder bed fusion processes

Titan aluminium alloys belong to the group of α–β-alloys, which are used for many applications in industry due to their advantageous mechanical properties, e.g. for laser powder bed fusion (PBF-LB) processes. However, the composition of the crystal structure and the respective magnitude of the solid fraction highly influences the material properties of titan aluminium alloys. Specifically, the the

Prevalence of left atrial appendage thrombus and spontaneous echo contrast on transesophageal echocardiography in patients scheduled for pulmonary vein isolation

Background: To avoid causing a thromboembolic event in patients undergoing catheter ablation for atrial fibrillation (AF), patients are treated with oral anticoagulants (OAC) prior to the procedure. Despite being on anticoagulants, some patients develop a left atrial appendage thrombus (LAAT). To exclude the presence of LAAT, transesophageal ultrasound (TEE) is performed in all patients prior to t

Occupational second-hand smoke exposure : A comparative shotgun proteomics study on nasal epithelia from healthy restaurant workers

Non-smokers exposed to second-hand smoke (SHS) present risk of developing tobacco smoke-associated pathologies. To investigate the airway molecular response to SHS exposure that could be used in health risk assessment, comparative shotgun proteomics was performed on nasal epithelium from a group of healthy restaurant workers, non-smokers (never and former) exposed and not exposed to SHS in the wor

Multi-objective Optimization and GIS to Improve Climate Change Induced Disaster Risk Management in Africa

We live in an era that suffers from climate change issues, not least disaster risks induced by climate change. While measures, such as proper evacuation plans, are required to reduce the negative impacts of disasters when they hit, actions should also be taken to reduce climate change effects by e.g. increasing the use of renewable energies or proper urban land-use allocation, where climate change

Muslim women in Ireland

This chapter explores the experiences of Muslim women, both migrants and converts, in Ireland. For migrant Muslim women an attachment to the particular cultural understanding of Islam in their countries of origin is dominant. Irish converts likewise do not constitute a monolithic entity but also espouse various understandings of Islam, from Salafism to cultural definitions of Islam of the converts

Mapping Shia muslim communities in Europe : Local and transnational dimensions: An introduction to the special issue

This article provides an introduction to the special issue on Mapping Shia Muslim Communities in Europe.1 With six empirically rich case studies on Shia Muslim communities in various European countries, this issue intends: first, to illustrate the historical developments and emergence of the Shia presence in Europe; second, to highlight the local particularities of the various Shia communities wit

Shiʿi Materiality Beyond Karbala : Religion That Matters

This book examines material and multi-sensorial expressions of Shiʿi Islam in diverse, and understudied demographic and geographic contexts.It engages with conceptual debates and makes several propositions that push the frontiers of scholarship on Islamic and Religious Studies, Material Religion, Heritage Studies, and Anthropology and Sociology of Religion.The contributions presented in this volum