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Cutaneous human papillomaviruses found in sun-exposed skin: Beta-papillomavirus species 2 predominates in squamous cell carcinoma

Background. A spectrum of cutaneous human papillomaviruses (HPVs) is detectable in nonmelanoma skin cancers, as well as in healthy skin, but the significance that the presence of these types of HPV DNA has for the pathogenesis of skin cancer remains unclear. Methods. We studied 349 nonimmunosuppressed patients with skin lesions (82 with squamous cell carcinomas, 126 with basal cell carcinomas, 49

Regeneration of commercial TiO2-V2O5-WO3SCR catalysts used in bio fuel plants

Deactivation of SCR catalysts applied in bio fuel plants is a major problem due to higher amounts of potassium in bio fuel compared to other fuels. Regeneration of deactivated catalysts seems to be a promising way for minimising the total cost of bio fuel plants and great potential lies in finding regeneration processes that can be used commercially. The first applied regeneration method was washi

Absence of mutations of the BRAF gene in malignant melanoma of soft parts (clear cell sarcoma of tendons and aponeuroses)

Malignant melanoma of soft parts (MMSP), also called clear cell sarcoma of tendons and aponeuroses, is cytogenetically characterized by the t(12;22)(q13;q12) resulting in the chimeric EWSR1/ATF1 gene. MMSP shares a number of morphologic, histologic, and immunohistochemical features with malignant melanoma of the skin, causing diagnostic difficulties in the distinction between MMSP and metastatic m

Melatonin as antioxidant, geroprotector and anticarcinogen

The effect of the pineal indole hormone melatonin on the life span of mice, rats and fruit flies has been studied using various approaches. It has been observed that in female CBA, SHR, SAM and transgenic HER-2/neu mice long-term administration of melatonin was followed by an increase in the mean life span. In rats, melatonin treatment increased survival of male and female rats. In D. melanogaster

Videoradiographic analysis of how carbonated thin liquids and thickened liquids affect the physiology of swallowing in subjects with aspiration on thin liquids.

Purpose: To analyze how carbonated thin liquids affected the physiology of swallowing in dysphagic patients. Material and Methods: 40 patients were analyzed; 36 were neurologically impaired. During a therapeutic videoradiographic swallowing examination the patients had to swallow liquids with the following consistencies three times: thin, thickened and carbonated. The liquids were given in doses

Impact of iron status on cadmium uptake in suckling piglets

Low iron status is known to increase the uptake of dietary cadmium in both adolescents and adults and there are indications that cadmium is absorbed from the intestine by the two major iron transporters divalent metal transporter 1 (DMT1) and ferroportin 1 (FPN1), In addition, it has been suggested that duodenal metallothionein (MT) may limit the transport of cadmium across the intestinal epitheli

The VO2* defect in silicon

The vacancy-dioxygen complex (VO2) is one of the main defects formed in irradiated Cz-Si crystals upon annealing (or irradiation) in the temperature range 300-400degreesC. In this defect two oxygen atoms share a vacancy, each bonded to two silicon neighbors. Independent vibrations of these 0 atoms give rise to one infrared absorption band at 895.5 cm(-1) at 10 K. We report on an experimentally dis

A first search for coincident gravitational waves and high energy neutrinos using LIGO, Virgo and ANTARES data from 2007

We present the results of the first search for gravitational wave bursts associated with high energy neutrinos. Together, these messengers could reveal new, hidden sources that are not observed by conventional photon astronomy, particularly at high energy. Our search uses neutrinos detected by the underwater neutrino telescope ANTARES in its 5 line configuration during the period January - Septemb

The protease inhibitor cystatin C is differentially expressed among dendritic cell populations, but does not control antigen presentation

Dendritic cells (DC) undergo complex developmental changes during maturation. The MHC class H (MHC H) molecules of immature DC accumulate in intracellular compartments, but are expressed at high levels on the plasma membrane upon DC maturation. It has been proposed that the cysteine protease inhibitor cystatin C (CyC) plays a pivotal role in the control of this process by regulating the activity o

Light-induced linear dichroism in photoreversibly photocromic sensor pigments 6. Relation between the 2 pigments of the mycochrome system in Alternaria-Chichorii

Conidiation in A. cichorii Nattras is reversibly stimulated by near UV radiation (NUV .apprx. 313 nm) and inhibited by blue light (.apprx. 450 nm) and apparently is a mycochrome-mediated process. After induction with plane-polarized NUV, blue light polarized perpendicularly to the NUV was more effective in counteracting the induction than was blue light polarized parallel to the NUV. Both the blue

Hydrolysis of the cubic liquid-crystalline phase of glyceryl monooleate by human pancreatic lipases

Glyceryl monooleate (GMO) and other unsaturated long-chain monoglycerides show peculiar phase behaviour characterised by the presence of one or more cubic liquid-crystalline phases. In the present study, hydrolysis of cubic lipid-water phases formed by GMO were determined. Human pancreatic carboxyl ester lipase (CEL), colipase-dependent lipase with colipase, human duodenal contents and rat pancrea

Predictive markers for tamoxifen response in primary breast cancer

Popular Abstract in Swedish Bröstcancer är den vanligaste cancersjukdomen hos kvinnor i västvärlden och årligen nydiagnosticeras omkring 7000 patienter, bara i Sverige. Antalet nyinsjuknade ökar för varje år medan dödligheten sjunker och de främsta orsakerna till detta tros vara förbättrad diagnostik via mammografiscreening och nya behandlingsmöjligheter. Bröstcancer behandlas primärt med kirurgi,It is well-known that a majority of breast cancers are hormone-dependent, making endocrine therapy an important adjuvant treatment after surgery. Susceptibility to endocrine treatment is determined by the presence of estrogen receptors (ER) and progesterone receptors (PR) in the tumors. Tamoxifen is the most well-established endocrine treatment available, inhibiting tumor growth and improving surv

Seasonality extraction by function fitting to time-series of satellite sensor data

A new method for extracting seasonality information from time-series of satellite sensor data is presented. The method is based on nonlinear least squares fits of asymmetric Gaussian model functions to the time-series. The smooth model functions are then used for defining key seasonality parameters, such as the number of growing seasons, the beginning and end of the seasons, and the rates of growt

A novel interaction between type IV pili of Neisseria gonorrhoeae and the human complement regulator C4B-binding protein

C4b-binding protein (C4BP) is an important plasma inhibitor of the classical pathway of complement activation. Several bacterial pathogens bind C4BP, which may contribute to their virulence. In the present report we demonstrate that isolated type IV pili from Neisseria gonorrhoeae bind human C4BP in a dose-dependent and saturable manner. C4BP consists of seven identical alpha-chains and one beta-c

Supplementation with conjugated linoleic acid causes isomer-dependent oxidative stress and elevated C-reactive protein - A potential link to fatty acid-induced insulin resistance

Background-Conjugated linoleic acids (CLAs), a group of fatty acids shown to have beneficial effects in animals, are also used as weight loss supplements. Recently, we reported that the t10c12 CLA-isomer caused insulin resistance in abdominally obese men via unknown mechanisms. The aim of the present study was to examine whether CLA has isomer-specific effects on oxidative stress or inflammatory b

HIV/AIDS knowledge and condom use among Somali and Sudanese immigrants in Denmark.

Aims: This study explores the knowledge, attitudes and practices among Somali and Sudanese immigrants in Denmark with regard to HIV/AIDS and condom use. Material and methods: A 78-item questionnaire, divided into five thematic sections, was given to 192 purposively selected Sudanese and Somalis of both sexes, aged 18-49, who had lived in Denmark for one or more years. It was administered in Arabic

The impact of active intervention on the spread of penicillin-resistant streptococcus pneumoniae in Swedish day-care centres

Policies for handling cases of penicillin-non-susceptible Streptococcus pneumoniae (PNSP) in day-care groups vary between different counties in Sweden. The aim of this study was to evaluate the epidemiological effect of excluding PNSP-carriers from children's day-care centres (DCC). We followed the incidence in 14 DCC groups with ongoing PNSP-spread, by repeated group screens until no further case