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Multiple sclerosis (MS) is a chronic inflammatory disease of central nervous system (CNS) which is thought to arise from a breakdown of immunological tolerance in CD4 cells. The aim of this thesis is to improve our understanding of regulation mechanisms of T cell-dependent chronic inflammation in the CNS and explore ways to overcome the onset and progression of the disease, which can be an importa

High-spin states of a number of nuclei near Ni-56 have been studied by means of the Si-28(Ar-36,x alpha ypzn) reaction. The GAMMASPHERE array in conjunction with light charged particle and neutron detectors were used to identify and cleanly select the fusion-evaporation products. In addition to significantly extending the level schemes of many previously known N = Z nuclei from Fe-52 to Cu-58, exc

The aqueous gallium(III)-acetate system was studied in 0.6 M Na(Cl) at 25 degreesC using a multi-technique approach, including potentiometry, IR spectroscopy, EXAFS spectroscopy and molecular orbital calculations. The potentiometric data were satisfactorily explained by a model which includes one mononuclear and one binuclear complex. The corresponding equilibrium constants defined according to th

The present work studies the separated flow in a square channel with ribs on one wall by using the PIV method. In this study, the spacing between ribs is kept constant and the heights of rib are varied in order to investigate the influence of the pitch-to-height ratio, P/e on the flow structures. Depending on the various pitch ratios, the enclosure between ribs can be regarded as closed or open ca

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Data erasure is considered an essential requirement for a practical optical time-domain memory, and it requires that the laser used have very good frequency stability. Such a laser is developed for this work, and data erasure is demonstrated with a sample of YSiO5:Eu3+ for write/rewrite pulse sequences of up to a duration of 100 μs. This is two orders of magnitude longer than had been achieved pre

Popular Abstract in Swedish Stroke är en vanlig och mycket allvarlig form av hjärt-kärlsjukdom som uppkommer på grund av försämrat blodflöde i en del av hjärnan. Eftersom hjärnan är extremt beroende av kontinuerlig tillförsel av syre och näringsämnen leder tillståndet snabbt till hjärnskada. Det finns tre typer av stroke; hjärninfarkt, hjärnblödning och subaraknoidalblödning (blödning under en hjäThe present thesis aimed to examine how ischemic stroke affects the vascular endothelin and angiotensin systems in cerebral arteries. To study vascular receptor changes in ischemic stroke transient focal ischemia was induced in rats. In addition, rat cerebral arteries and arterial smooth muscle cells were cultured for further analysis of cerebrovascular receptor regulation. For functional studies

Dispersion coefficients for turbulent flow are commonly available, but the common models are not easily implemented for fast computation of dispersion in time-dependent large flow systems. Criteria were developed to aid in the choice of parameters for a model combining plug flow with the N-continuously stirred-tanks model to obtain the best agreement with the pure axial-dispersed plug-flow model,

A stirred tank membrane reactor is used to study the kinetics of polygalacturonic acid (PGA) enzymatic hydrolysis. The reactor operates in semicontinuous configuration: the native biopolymer is loaded at the initial time and the system is continuously fed with the buffer. The effect of retention time (from 10 1 to 142 min) and membrane molecular weight cutoff (from I to 30 kDa) on the rate of perm

High resolution core level spectroscopy in combination with density functional theory calculations are used to study the satellite feature of the Ru-3d(5/2), core level spectrum whose interpretation is still a matter of debate. We present evidence that the satellite peak is not related to any structural properties of the RuO2(1 1 0) surface. The binding energy shift between the Ru-3d(5/2) componen

Resistance to the HER-2 targeting drug trastuzumab can be observed clinically, but the lack of suitable experimental models hampers studies of resistance mechanisms. We characterized a HER-2–positive carcinoma cell line (JIMT-1) derived from a 62-year-old breast cancer patient which was clinically resistant to trastuzumab. Multicolor fluorescence in situ hybridization revealed a complex hyperdiplo

A study on a possible solar wind interaction with the North AtlanticOscillation (NAO) is performed. Results are presented suggesting arelationship between the NAO index and the electric field strength E ofthe solar wind. A possible scenario for the suggested interaction isthat an electromagnetic disturbance is generated by the solar wind inthe global electric circuit of the ionosphere. This distur

PURPOSE: Adenosine triphosphate (ATP) (Sigma Chemical Co., St. Louis, Missouri) is known to contract animal as well as human detrusor muscle and recent investigations have shown an involvement of ligand gated purinergic-1 receptors in detrusor contraction. In addition, ligand gated purinergic-3 receptors have been demonstrated on suburothelial sensory nerves (C-fibers) and may be involved in diste