Sökresultat

Cell replacement therapies for Parkinson's disease (PD) based on transplantation of pluripotent stem cell-derived dopaminergic neurons are now entering clinical trials. Here, we present quality, safety, and efficacy data supporting the first-in-human STEM-PD phase I/IIa clinical trial along with the trial design. The STEM-PD product was manufactured under GMP and quality tested in vitro and in viv

Why theatre? We can’t ask ourselves a more basic question than that and at the same time no question is harder to give an answer to. Why do we make theatre? What purpose does it have or does it even need to have a purpose? Usually, the answers are given by the making of theatre itself – but suddenly we find ourselves in a situation that has shaken up our ways of searching for the answers.

As a research field, social movement and political project, degrowth is a multi-faceted phenomenon. It brings together a range of practices including alternative forms of living and initiatives of various kinds in civil society, business and the state. Yet no comprehensive theory of degrowth transformations has so far been developed. Deep transformations fills this gap. It develops a theory of deg

The chapter identifies several themes that are potentially significant in future research on Gen Z and sustainable tourism consumption. The need for cross-generational and cross-cultural research is identified, especially in a longitudinal context. It is also noted that the majority of research is undertaken in the developed world and the authors highlight the need for research in less developed c

Tracing the events surrounding the 1909 general strike (storstrejken), this article explores the role of a network of People’s Parks and People’s Houses, since the early 1890s established by the labour movement to counterweight the difficulties of ensuring stable meeting spaces. As regional and local authorities during the 1909 strike banned striking workers to access many public spaces and condit

Bimetallic nanoparticles have gained significant attention in catalysis as potential alternatives to expensive catalysts based on noble metals. In this study, we investigate the compositional tuning of Pd–Cu bimetallic nanoparticles using a physical synthesis method called spark ablation. By utilizing pure and alloyed electrodes in different configurations, we demonstrate the ability to tailor the

How are Black female candidates’ race and gender represented in newspaper coverage of electoral campaigns? Are intersectional stereotypes of Black women in general reflected in representations of Black women in elite politics? This study employs an open ended qualitative content analysis of coverage of the 2012 general election to consider the way in which racial and gendered references frame the

This chapter introduces the British MPs’ expenses scandal: its origins, evolution and consequences. We argue that despite some early predictions, the scandal was limited in its impact: the purported ‘revolution’ never occurred. We briefly review the comparative literature on the political impact of scandal, which illustrates why the effects of scandals are usually limited and reasons why voters ma

This paper draws together reflections, approaches and practical lessons from 151 development programs that are, in various ways, seeking both to be gender aware and to understand and engage with power and politics. It aims to provide food for thought for donor organisations and development programs. Gender aware programming has been on the development agenda for at least a generation. Most donor o

Importance: Infection control guidelines have historically classified high-flow nasal oxygen and noninvasive ventilation as aerosol-generating procedures that require specialized infection prevention and control measures. Objective: To evaluate the current evidence that high-flow nasal oxygen and noninvasive ventilation are associated with pathogen-laden aerosols and aerosol generation. Data Sourc

Background: The understanding of inhaled particle respiratory tract deposition is a key link to understand the health effects of particles or the efficiency for medical drug delivery via the lung. However, there are few experimental data on particle respiratory tract deposition, and the existing data deviates considerably when comparing results for particles > 1 μm. Methods: We designed an experim

Introduction Firefighters have increased risk of chronic respiratory disease. Standard clinical techniques used in medical checkups may not detect the earliest microstructural changes in peripheral airways. A new technique called Airspace Dimension Assessment (AiDA) has been shown to enable early detection of emphysema in COPD. This method may be useful in the occupational setting to detect early

Measurements of single-, double-, and triple-differential cross-sections are presented for boosted top-quark pair-production in 13 TeV proton–proton collisions recorded by the ATLAS detector at the LHC. The top quarks are observed through their hadronic decay and reconstructed as large-radius jets with the leading jet having transverse momentum (pT) greater than 500 GeV. The observed data are unfo

Background: The apolipoprotein E (APOE) ε4 allele is associated with higher cholesterol levels, and an increased risk of developing Alzheimer’s disease (AD) and amyloid-related imaging abnormalities after initiation of amyloid-modifying therapies. A worse cognitive response to cholinesterase inhibitor (ChEI) treatment and longitudinal outcome in APOE ε4-carriers has been observed. Based on these c