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The PRDM family of methyltransferases has been implicated in cellular proliferation and differentiation and is deregulated in human diseases, most notably in cancer. PRDMs are related to the SET domain family of methyltransferases; however, from the 19 PRDMs only a few PRDMs with defined enzymatic activities are known. PRDM15 is an uncharacterized transcriptional regulator, with significant struct
BACKGROUND: Triglyceride-glucose (TyG) index is a useful low-cost marker of insulin resistance. We aimed to evaluate the association between TyG index and arterial stiffness, incidence of diabetes, adverse cardiovascular outcomes, and all-cause and cardiovascular mortality in two large prospective Swedish cohorts, the Malmö Diet and Cancer Study-Cardiovascular Cohort (MDCS-CV) and the Malmö Preven
The current concept of social resilience, which developed from the classic definition of resilience, neglects social resilience as a social phenomenon including social experiences and practices in the face of change and adversity. I argue that framing social resilience as a capacity or ability undermines its characteristics as a complex and contextualized social phenomenon that contributes to adap
The purpose of this study was to investigate the cause of death in subjects with α-synucleinopathies (ASs) and the confirmed presence of cardiac α-synuclein (α-syn), compared to non-AS disorders in a neuropathologically confirmed cohort. In total, 78 neuropathologically confirmed AS cases positive for cardiac α-syn were included in the study. Individuals with other neurocognitive diseases, having
The structure of a freeze-dried material is essential for its ability to preserve and protect biologics such as proteins, cells and other sensitive structures. The structure of a typical freeze-dried matrix can be described as pores surrounded by thin walls where the walls are the encapsulating material (for e.g. cells). The objective of this investigation is to evaluate X-ray microtomography (µCT
Purpose: Fatigue is a major symptom of ABI. Greater fatigue is associated with cognitive impairment. Our aim was to systematically review, describe and analyse the literature on the extent of this relationship. Methods: Five databases were searched from inception. Studies were included where: participants had a defined clinical diagnosis of ABI which included TBI, stroke or subarachnoid haemorrhag
Over the past decades, global warming has led to a lengthening of the time window during which temperatures remain favorable for carbon assimilation and tree growth, resulting in a lengthening of the green season. The extent to which forest green seasons have tracked the lengthening of this favorable period under climate warming, however, has not been quantified to date. Here, we used remote sensi
Introduction: Biomarkers for the prediction of cognitive decline in patients with amnestic mild cognitive impairment (MCI) and amnestic mild dementia are needed for both clinical practice and clinical trials. Methods: We evaluated the ability of tau-PET (positron emission tomography), cortical atrophy on magnetic resonance imaging (MRI), baseline cognition, apolipoprotein E gene (APOE) status, pla
For the past years, the national rhetoric in Sweden has changed. Due to the Russian actions in Ukraine and Crimea, efforts towards mobilizing military and civil preparedness increased. The concept of the ‘total defence’ was reintroduced and has led to shifting priorities in Swedish politics, serving as a happy object and remedy in times of security threat and social anxiety. The article critically
Climate change stressors, including warming and heatwaves, can alter plankton composition and dominance patterns in temperate shallow lakes, which can disrupt ecosystem function and curtail ecosystem services. Understanding how these alterations could take place under future climates is therefore important. To understand such changes, we performed a year-long mesocosm experiment with controls refl
Hereditary ataxia represents a heterogeneous group of rare disorders with the chronic progression of motor symptoms that often become debilitating. Many forms include additional neurological, cognitive, or other symptoms. Most of these disorders lack specific treatment. We aimed to investigate aspects of patients’ quality of life, experiences, and expectations. Patients with a diagnosis of heredit
Background: Parkinson's disease (PD) is a progressive neurodegenerative disorder associated with substantial costs which increase with progression state. However, few studies have investigated the association between costs and health related quality of life. Objectives: To estimate the relationship between costs and health related quality of life, measured by the Parkinson's disease Quality of Lif
Introduction: Research comparing levodopa/carbidopa intestinal gel (LCIG), deep brain stimulation (DBS), and continuous subcutaneous apomorphine infusion (CSAI) for advanced Parkinson’s disease (PD) is lacking. This network meta-analysis (NMA) assessed the comparative effectiveness of LCIG, DBS, CSAI and best medical therapy (BMT) in reducing off-time and improving quality of life (QoL) in patient
Optimal stomatal theory predicts that stomata operate to maximise photosynthesis (Anet) and minimise transpirational water loss to achieve optimal intrinsic water-use efficiency (iWUE). We tested whether this theory can predict stomatal responses to elevated atmospheric CO2 (eCO2), and whether it can capture differences in responsiveness among woody plant functional types (PFTs). We conducted a me
Climatic conditions affect animals but range-wide impacts at the population level remain largely unknown, especially in migratory species. However, studying climate–population relationships is still challenging in small migrants due to a lack of efficient and cost-effective geographic tracking method. Spatial distribution patterns of environmental stable isotopes (so called ‘isoscapes’) generally
Context: Agri-environment schemes support land management interventions that benefit biodiversity, environmental objectives, and other public goods. Process-based model simulations suggest the English scheme, as implemented in 2016, increased wild bee pollination services to pollinator-dependent crops and non-crop areas in a geographically heterogeneous manner. Objectives: We investigated which in
Aims/hypothesis: Monogenic forms of diabetes (MODY, neonatal diabetes mellitus and syndromic forms) are rare, and affected individuals may be misclassified and treated suboptimally. The prevalence of type 1 diabetes is high in Finnish children but systematic screening for monogenic diabetes has not been conducted. We assessed the prevalence and clinical manifestations of monogenic diabetes in chil
The international legal system of access and benefit-sharing of genetic resources (or ABS) under the Convention on Biological Diversity (CBD) is an ever-evolving field as its material, temporal and activity scope is still under discussion to meet the needs of the advancement of research and development activities as well as the questions of fairness and equity that evolve with them. Activities, su
