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Irreversible inhibitors of Bruton tyrosine kinase (BTK), pioneered by ibrutinib, have become breakthrough drugs in the treatment of leukemias and lymphomas. Resistance variants (mutations) occur, but in contrast to those identified for many other tyrosine kinase inhibitors, they affect less frequently the “gatekeeper” residue in the catalytic domain. In this study we carried out variation scanning

People with Parkinson’s disease (PD) experience a gradual loss of functional abilities that affects all facets of their daily life. There is a lack of longitudinal studies on coping styles in relation to the disease progression among people with PD. The aim of this study was to explore how coping styles in PD evolve over a 3-year period. Data from the longitudinal project “Home and Health in Peopl

Chronic pelvic pain (CPP) is chronic or persistent pain perceived in structures related to the pelvis of men and women. Patients with CPP may have pain refractory to conventional management strategies. Botulinum toxin A (BTX-A) injection is a potential therapeutic option in patients with CPP. Beneficial effects of BTX-A on pain, quality of life, and functional symptoms were seen in patients with c

The existing information supports the use of this material as described in this safety assessment. 2-Mercaptopropionic acid was evaluated for genotoxicity, repeated dose toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, and environmental safety. Data show that 2-mercaptopropionic acid is not genotoxic. The repeated dose, reproductive

The gut microbiome is shaped by diet and influences host metabolism; however, these links are complex and can be unique to each individual. We performed deep metagenomic sequencing of 1,203 gut microbiomes from 1,098 individuals enrolled in the Personalised Responses to Dietary Composition Trial (PREDICT 1) study, whose detailed long-term diet information, as well as hundreds of fasting and same-m

Biografisk artikel om skådespelerskan, revyartisten och sufflören Nita Hårleman (1891-1961).

The existing information supports the use of this material as described in this safety assessment. 3,7-Dimethyl-1,3,6-octatriene was evaluated for genotoxicity, repeated dose toxicity, developmental and reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, and environmental safety. Data from 3,7-dimethyl-1,3,6-octatriene and read-across analog myr

Prisons are institutions through which states exert social control and deprive citizens of rights; where entitlements of citizens are limited to the bare minimum deemed acceptable to a given state. Therefore, prisons are institutions which reveal core aspects of the relation between a state and its citizens. In authoritarian regimes, as Myanmar was in a very recent past, prisons are places in whic

This article takes as its starting point the similar, yet differing, experiences of hearing voices among prisoners in Myanmar. It discusses why the experience of hearing voices described by prisoners is regarded as an occasion to share compassion when it occurs during meditation retreats and as torture when it occurs in solitary confinement. The article uses the concept of liminality to make sense

This commentary applauds Held’s (2020) argument for the importance of considering the risk of epistemological violence implicit in psychology. In addition, this commentary suggests the argument can be furthered by looking to the ontological turn within anthropology and considering not only the risk of epistemic, but of ontological violence in psychological research as well as in therapeutic practi

This article discusses the concept of 'access' within ethnography. Schatz's conception of access as finding the nearest possible vantage point lays the foundation for a discussion of 15 months of fieldwork conducted in Myanmar for a study of experiences of imprisonment that had little access to the inside of these institutions. The article goes beyond an understanding of access framed by a focus o

Lignin, the world's most abundant biopolymer with high aromaticity, has huge potential as a renewable feedstock replacing petroleum for the production of chemicals, fuels and functional materials. The enhanced utilization of lignin would improve the economic viability of existing pulp and paper mills, as well as lignocellulosic biorefineries, where lignin is highly available, but mostly incinerate

Drawing on participatory action research conducted in Sierra Leone, Kosovo and the Philippines, Human Rights in Prisons analyses encounters between rights-based non-governmental organisations and prisons. It explores the previously under-researched perspectives of prison staff and prisoners on their lives and relationships.

Background: It is unknown whether the rate of psychiatric disorders and cardiovascular disease increases during the diagnostic workup of suspected prostate cancer.Methods: We designed a population-based cohort study including 579 992 men living during 2005-2014 in Skåne, Sweden, according to the Swedish Total Population Register and the Skåne Healthcare Register (SHR). We used the Swedish Cancer R

Prisons inevitably leave their mark on all who pass through their gates. In this article two psychologists reflect on how prisons left their mark during our ethnographic fieldwork in developing countries. Via reflection on our own experiences the article advances thediscussion of the role of emotions in prison ethnographies. The article is based on a meta- analysis of field notes with a focus on e

In speech, the connection between sounds and word meanings is mostly arbitrary. However, among basic concepts of the vocabulary, several words can be shown to exhibit some degree of form–meaning resemblance, a feature labelled vocal iconicity. Vocal iconicity plays a role in first language acquisition and was likely prominent also in pre-historic language. However, an unsolved question is how voca

Background: Patients with wake-up ischemic stroke who have evidence of salvageable tissue on advanced imaging can benefit from intravenous thrombolysis. It is not known whether patients who do not fulfil such imaging criteria might benefit from treatment, but studies indicate that treatment based on non-contrast CT criteria may be safe. Tenecteplase has shown promising results in patients with acu