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The performance of the Sub Grid Scale models is studied by simulating a separated flow over a wavy channel. The first and second order statistical moments of the resolved velocities obtained by using Large-Eddy simulations at different mesh resolutions are compared with Direct Numerical Simulations data. The effectiveness of modeling the wall stresses by using local log-law is then tested on a rel
An increasing body of literature explores the role of transnational municipal networks (TMNs) in governing sustainable development. As associations, one key task of TMNs is to represent their members through production and dissemination of information and knowledge concerning municipal action for sustainable development. Case studies, often emphasising best practice, are used by many TMNs to fulfi
Researchers in academic disciplines, including but not limited to information systems, have long been aware of, but have not linked, two research issues: one issue is the lack of relevance, despite the plethora of rigor, in their research, the other issue is the distinction between statistical significance and practical significance, where the latter is no less important than the former. In this e
This paper provides a report on the first iteration of a design-driven research project for delivering an IT performancemanagement (ITPM) solution. This research is situated in the context of existing IT performance related studies. Designscience research (DSR) is the underpinning research approach for crafting the ensuing ITPM solution. Three challenges in theITPM area are identified and a design
Reviewing the information systems (IS) literature shows the prevalence of studies claiming to exploit the grounded theory (GT) method. However, most of these studies follow an objectivist approach to GT. This manuscript addresses another recognized yet rarely used GT approach in IS: constructivist. The importance of IS constructivist research is briefly explained. This is followed with a recapitul
Existing criteria recommended by ACC/ESC for identifying patients with ST-elevation myocardial infarction (STEMI) from the 12-lead ECG perform with high specificity (SP), but low sensitivity (SE). In our previous study, we found that the SE of acute ischemia detection can be markedly improved without any loss of SP by calculating, from the 12-lead ECG, ST elevation in 3 vessel-specific leads (VSLs
Background: Systemic Sclerosis (SSc) is an autoimmune disease characterized by vascular and immune dysfunction. A hallmark of SSc is the excessive accumulation of extracellular matrix in the skin and in internal organs. There is a high and unmet medical need for novel therapies in this disease. The pathogenesis of SSc is complex and still poorly understood, but the innate immune system has emerged
AQP9 is known to facilitate hepatocyte glycerol uptake. Murine AQP9 protein expression has been verified in liver, skin, epididymis, epidermis and neuronal cells using knockout mice. Further expression sites have been reported in humans. We aimed to verify AQP9 expression in a large set of human normal organs, different cancer types, rheumatoid arthritis synovial biopsies as well as in cell lines
In the vehicular communication channels, the mobility of the receiver (RX) and the transmitter (TX) along with the movements of interacting objects in the propagation environment result in significant non-stationary channel fading. The channel impulse response exhibits not just significant delay- and Doppler spreads, but also the delay- and Doppler spreads themselves are changing over the time- an
Background: Contact allergies to the preservatives formaldehyde and methylchloroisothiazolinone (MCI)/methylisothiazolinone (MI) have been reported to appear together at a statistically significant level. Recently, revisions concerning the patch test preparations of MCI/MI, MI and formaldehyde have been recommended for the European baseline series. Aim: To investigate (i) the number of concomitant
Many studies have reported an increased incidence of inhibitors in previously untreated patients (PUPs) with severe haemophilia A after the introduction of recombinant products. It was the objective of this study to investigate whether the inhibitor incidence has increased between 1990 and 2009 in an unselected cohort of PUPs with severe haemophilia A (FVIII<1 %). Patients were consecutively recru
The group Parkinson Inside Out is composed of health professionals and academic researchers who have been diagnosed with Parkinson's Disease. In our discussions we try to make use of both our inside perspective as patients, and our outside perspective as professionals. In this paper, we apply the two perspectives to the Impulse Control Disorders. These impulsive behaviour patterns are thought to b
