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Optical spectroscopy for tissue diagnostics

Biomedical Optics as an interdisciplinary field of science has been developed during many years and is experiencing tremendous growth, to cover a wide range of optical techniques and methods, utilized for medical therapeutic and diagnostic purposes. Biomedical optics contributes in the introducing methods and creation of devices used in healthcare of various specialties, such as ophthalmology, car

Joint estimation scheme of front-end imperfection in MB-OFDM systems

In this paper, we investigate the analog front-end imperfection in multi-band orthogonal frequency division multiplexing (MB-OFDM) ultra-wideband (UWB) systems and propose a joint estimation and compensation scheme. The estimation of CFO and SFO is presented on frequency domain, which is robust to frequency dependent I/Q imbalance. After that, I/Q imbalance and channel response is jointly estimate

Preclinical Molecular Imaging using Multi-Isotope Digital Autoradiography - Techniques and Applications

Popular Abstract in Swedish Bildgivande system har en allt mer framträdande roll inom sjukvård och medicinsk forskning. En del av dessa system fungerar genom att en patient eller ett försöksdjur injiceras med ett läkemedel märkt med ett radioaktivt ämne, och sedan mäts den strålning som detta ämne avger för att skapa en bild av var ämnet, och därmed läkemedlet, befinner sig. Det finns både system Molecular imaging, both in vivo and ex vivo, is playing an increasingly important role in preclinical medical research. When using radionuclide-labeled tracers, e.g. in the development of radiopharmaceuticals for diagnostic imaging or for radionuclide therapy, quantitative in vivo imaging can be performed using emission tomography. Quantitative autoradiography of thin tissue sections is employed t

Risk factors of future suicide in suicide attempters - A comparison between suicides and matched survivors

The objective of this study was to find risk factors for suicide by looking for clinical and care/treatment consumption differences between 15 hospitalized suicide attempters, who later committed suicide ("completers''), and 15 suicide attempters who did not ("non-completers''), matched according to sex, age and principal diagnosis. Completers had significantly more often attempted suicide after t

Warm eyes provide superior vision in swordfishes

Large and powerful ocean predators such as swordfishes, some tunas, and several shark species are unique among fishes in that they are capable of maintaining elevated body temperatures (endothermy) when hunting for prey in deep and cold water [1-3]. In these animals, warming the central nervous system and the eyes is the one common feature of this energetically costly adaptation [4]. In the swordf

Convex programs for temporal verification of nonlinear dynamical systems

A methodology for safety verification of continuous and hybrid systems using barrier certi.ficates has been proposed recently. Conditions that must be satisfi.ed by a barrier certi. cate can be formulated as a convex program, and the feasibility of the program implies system safety in the sense that there is no trajectory starting from a given set of initial states that reaches a given unsafe regi

Neurophysiological changes during insulin-induced hypoglycaemia and in the recovery period following glucose infusion in type 1 (insulin-dependent) diabetes mellitus and in normal man

Hypoglycaemia (median venous blood glucose 1.8 mmol/l; range 1.6-2.3) was induced by an intravenous infusion of regular insulin in eight patients with Type 1 (insulin-dependent) diabetes mellitus (age 28.0 +/- 7.4 years; mean +/- SD, duration 15.5 +/- 5.1 years) and in 12 age-matched healthy male control subjects. Multi-channel frequency analysis of electroencephalogram (electrophysiologic brain m

Binding of human C4BP to the hypervariable region of M protein: a molecular mechanism of phagocytosis resistance in Streptococcus pyogenes

The amino-terminal hypervariable region (HVR) of streptococcal M protein is required for the ability of this virulence factor to confer phagocytosis resistance. The function of the HVR has remained unknown, but the finding that many HVRs with extremely divergent sequences bind the human complement regulator C4b-binding protein (C4BP) has suggested that this ligand may play a role in phagocytosis r

Having the wrong friends? Peer effects in adolescent substance use

Swedish cross-sectional survey data on young individuals aged 12-18-year-old was used to analyse school-class based peer effects in binge drinking, smoking and illicit-drug use. Significant and positive peer effects were found for all three activities. By introducing school/grade fixed effects, the estimated peer effects were identified by variation in peer behaviour across school-classes within s

Laminin isoforms differentially regulate adhesion, spreading, proliferation, and ERK activation of beta1 integrin-null cells.

The presence of many laminin receptors of the β1 integrin family on most cells makes it difficult to define the biological functions of other major laminin receptors such as integrin α6β4 and dystroglycan. We therefore tested the binding of a β1 integrin-null cell line GD25 to four different laminin variants. The cells were shown to produce dystroglycan, which based on affinity chromatography boun

Image artifacts due to a time-varying contrast medium concentration in 3D contrast-enhanced MRA

The purpose of this work was to study image effects due to time-varying contrast medium concentration in contrast-enhanced three dimensional (3D) magnetic resonance angiography (MRA) images. Two different simulation models (1D and 3D) and two different contrast medium variation schemes were used. Phantom measurements were also performed. Experiments were performed for several different bolus timin

Mitochondrial permeability transition in acute neurodegeneration.

Acute neurodegeneration in man is encountered during and following stroke, transient cardiac arrest, brain trauma, insulin-induced hypoglycemia and status epilepticus. All these severe clinical conditions are characterized by neuronal calcium overload, aberrant cell signaling, generation of free radicals and elevation of cellular free fatty acids, conditions that favor activation of the mitochondr

Effects of anti-secretory factor (ASF) on irritable bowel syndrome (IBS)

Objective. To evaluate the role of the endogenous protein anti-secretory factor (ASF) on the symptoms, especially loose stools, in irritable bowel ayndrome (IBS). Design. A diet with specially processed cereals (SPC) known to induce ASF production was used in patients with IBS, in an eight-week randomized, placebo-controlled study. Subjects. Eighty-two patients with IBS were randomized to a diet w

UDP acts as a growth factor for vascular smooth muscle cells by activation of P2Y(6) receptors.

Mitogenic effects of the extracellular nucleotides ATP and UTP are mediated by P2Y(1), P2Y(2), and P2Y(4) receptors. However, it has not been possible to examine the highly expressed UDP-sensitive P2Y(6) receptor because of the lack of stable, selective agonists. In rat aorta smooth muscle cells (vascular smooth muscle cells; VSMC), UDP and UTP stimulated (3)H-labeled thymidine incorporation with

A long-term record of Quercus decline, logging and fires in a southern Swedish Fagus-Picea forest

We reconstructed forest development and disturbance events (fire and logging) during the last 1000 yr with tree-ring data, pollen and charcoal analysis from a semi-natural Fagus sylvatica-Picea abies forest (ca. I km(2)) in the hemiboreal zone. According to pollen analysis, Quercus robur together with Pinus sylvestris was abundant in the forest until the turn of the 18th/19th centuries when these