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Crowding in the Eye Lens : Modeling the Multisubunit Protein β-Crystallin with a Colloidal Approach
We present a multiscale characterization of aqueous solutions of the bovine eye lens protein βH crystallin from dilute conditions up to dynamical arrest, combining dynamic light scattering, small-angle x-ray scattering, tracer-based microrheology, and neutron spin echo spectroscopy. We obtain a comprehensive explanation of the observed experimental signatures from a model of polydisperse hard sphe
August Schmitz och Furulund : Några aspekter på ett patriarkalt förhållningssätt
Neuropsychological rehabilitation interventions for people with an acquired brain injury and their caregivers. A protocol for a systematic review of economic evaluation
Background: New emerging evidence has demonstrated the need for effective interventions to help people living with an acquired brain injury (ABI). Evidence on cost-effectiveness, which can help inform use of limited resources, is scarce in this area and therefore the purpose of this systematic review is to critically appraise and consolidate the current evidence on economic evaluations of ABI reha
Incisional negative pressure wound therapy in the prevention of surgical site infection after vascular surgery with inguinal incisions: rational and design of a randomized controlled trial (INVIPS-Trial).
Background/Aims: Inguinal incisions are a common route of access in vascular surgery. Due to anatomical challenges and a diverse bacterial flora in this area, surgical site infections (SSI) represent a common, debilitating and sometimes life-threatening complication. The INVIPS-Trial evaluates the role of Negative Pressure Wound Therapy (NPWT) on closed inguinal incisions in elective vascular surg
Adherence to instruction for use after endovascular repair of popliteal artery aneurysm
Objectives: Endovascular repair (ER) of popliteal artery aneurysm (PAA) is an alternative to open repair. However, there is no standardized protocol for when to opt for ER and the decision is therefore at the discretion of the clinician. This study aims to evaluate the adherence to the Instruction For Use (IFU) in patients undergoing ER for PAA and factors associated with stent graft patency at on
Special Issue in Memory of Professor Mário Costa
Laminar burning velocity measurements of ethanol+air and methanol+air flames at atmospheric and elevated pressures using a new Heat Flux setup
A new setup for burning velocity measurements of liquid fuels at elevated pressures using the Heat Flux method has been constructed. The burner design has been improved comparing to previous studies in this and other laboratories. Laminar burning velocities were determined experimentally for ethanol+air and methanol+air mixtures over a range of conditions including equivalence ratio (0.8 to 1.3),
Determining the Impact of High Residential Density on Indoor Environment, Energy Use, and Moisture Loads in Swedish Apartments-and Measures for Mitigation
Recently, there has been an increase in apartments with a large number of inhabitants, i.e., high residential density. This is partly due to a housing shortage in general but also increased migration, particularly in suburbs of major cities. This paper specifies issues that might be caused by high residential density by investigating the technical parameters influenced in Swedish apartments that aRecently, there has been an increase in apartments with a large number of inhabitants, i.e., high residential density. This is partly due to a housing shortage in general but also increased migration, particularly in suburbs of major cities. This paper specifies issues that might be caused by high residential density by investigating the technical parameters influenced in Swedish apartments that a
Assessing forest phenology : A multi-scale comparison of near-surface (UAV, spectral reflectance sensor, phenocam) and satellite (MODIS, sentinel-2) remote sensing
The monitoring of forest phenology based on observations from near-surface sensors such as Unmanned Aerial Vehicles (UAVs), PhenoCams, and Spectral Reflectance Sensors (SRS) over satellite sensors has recently gained significant attention in the field of remote sensing and vegetation phenology. However, exploring different aspects of forest phenology based on observations from these sensors and dr
The Irradiated brain microenvironment supports glioma stemness and survival via astrocyte-derived transglutaminase 2
The tumor microenvironment plays an essential role in supporting glioma stemness and radioresistance. Following radiotherapy, recurrent gliomas form in an irradiated microenvironment. Here we report that astrocytes, when pre-irradiated, increase stemness and survival of cocultured glioma cells. Tumor-naïve brains increased reactive astrocytes in response to radiation, and mice subjected to radiati
Patients' perspective on prostatic artery embolization : A qualitative study
Objectives: The aim was to describe the patients' experience of undergoing prostatic artery embolization.Methods: A retrospective qualitative interview study was undertaken with 15 patients of mean age 73 years who had undergone prostatic artery embolization with a median duration of 210 min at two medium sized hospitals in Sweden. The reasons for conducting prostatic artery embolization were clea
Sediment Sampling and Analysis in Rönne å at Ängelholm
This report presents the results of sediment sampling in Rönne å (river) at Ängelholm, located in the north-western part of Scania, which is the southern-most province in Sweden. The sampling and subsequent grain-size analysis were performed primarily to verify hypotheses about main mechanisms controlling local scour at a number of sites where scour holes had been observed in the river during deta
Aerosol Generated Core-shell Nanoparticles : Synthesis and Characterization
Aerosol technology is a promising platform to synthesize and study core-shellnanoparticles - a multi-elemental nanoparticle system where the core of one material is covered by a shell of another material. In this thesis, two distinctly separate strategies have been explored to synthesize core-shell nanoparticles by aerosol methods: physical vapor deposition (PVD) by evaporation, and surface segreg
Rash during lamotrigine treatment is not always drug hypersensitivity a retrospective cohort study among children and adults
Purpose Cutaneous adverse drug reactions (cADRs) are a major cause of lamotrigine (LTG) discontinuation. Remarkable variation in their reported incidence suggests confounders and diverse terms and definitions. The aim of this study was to identify immunological cADRs and to throw light on classification and differential diagnoses in children and adults. Methods Hospital records of 2683 patients wi
A community effort to identify and correct mislabeled samples in proteogenomic studies
In a community effort to combat sample mislabeling in multi-omic studies, computational solutions received show a wide range of accuracy. The final collaborative product, COSMO, achieves high performance. Applying COSMO to published datasets demonstrates biological impact of the tool.Sample mislabeling or misannotation has been a long-standing problem in scientific research, particularly prevalent in large-scale, multi-omic studies due to the complexity of multi-omic workflows. There exists an urgent need for implementing quality controls to automatically screen for and correct sample mislabels or misannotations in multi-omic studies. Here, we describe a crowdsourced precision
Comparable Initial Engagement of Intracellular Signaling Pathways by Parathyroid Hormone Receptor Ligands Teriparatide, Abaloparatide, and Long-Acting PTH
Multiple analogs of parathyroid hormone, all of which bind to the PTH/PTHrP receptor PTH1R, are used for patients with osteoporosis and hypoparathyroidism. Although ligands such as abaloparatide, teriparatide (hPTH 1-34 [TPTD]), and long-acting PTH (LA-PTH) show distinct biologic effects with respect to skeletal and mineral metabolism endpoints, the mechanistic basis for these clinically-important