In a community effort to combat sample mislabeling in multi-omic studies, computational solutions received show a wide range of accuracy. The final collaborative product, COSMO, achieves high performance. Applying COSMO to published datasets demonstrates biological impact of the tool.Sample mislabeling or misannotation has been a long-standing problem in scientific research, particularly prevalent in large-scale, multi-omic studies due to the complexity of multi-omic workflows. There exists an urgent need for implementing quality controls to automatically screen for and correct sample mislabels or misannotations in multi-omic studies. Here, we describe a crowdsourced precision

Multiple analogs of parathyroid hormone, all of which bind to the PTH/PTHrP receptor PTH1R, are used for patients with osteoporosis and hypoparathyroidism. Although ligands such as abaloparatide, teriparatide (hPTH 1-34 [TPTD]), and long-acting PTH (LA-PTH) show distinct biologic effects with respect to skeletal and mineral metabolism endpoints, the mechanistic basis for these clinically-important

Objectives. To evaluate beneficial effects of postmenopausal hormone replacement therapy (HRT) on endothelial function, measured as intraplatelet cyclic guanosine monophosphate (cGMP, mediator of nitric oxide), cyclic adenosine monophosphate (cAMP, mediator of prostacyclin) and plasma endothelin-1 (ET-1), and on monocyte activation, measured as plasma neopterin. Design. Part 1: double-blind random

Brigadier General Hossein Dehghan, a commander of the Islamic Revolutionary Guard Corps, has announced his candidacy for the Iranian presidential elections in June 2021. Dehghan has a toxic military background. In the 1980s he was responsible for the vicious crackdown on opponents of the Islamic regime, and he played a central role in the bombing of the US Marine barracks in Beirut that killed hun

A dictionary of Kalamang with more than 2700 words, with definitions in English and Malay. Also contains information on word class, pronunciation, etymology, semantic domain and more. Many entries have translated example sentences and pictures.

As a first approach to the comparison between the Andean and the Nordic countries, it is their specialisation on natural resource exportation. But even though both regions exported similar commodities at the beginning of the nineteenth century, how similar were they really? In this article, we analyse thecopper exportation of Chile and Norway in order to see small differences that can have made a

Amazonian ecosystems range from rainforest to open dryland vegetation, with a following decrease in biomass along the moisture gradient. Biomass can vary greatly at the ecological transition zone between grass dominated savannahs and the forest. It is not well understood if the transition zone could expand under climate change, and thereby reduce ecosystem stability and carbon storage in biomass.

Local commercial fishing is often claimed to attract tourists to coastal communities. We investigate the impact of local fishing on tourism demand, measured as overnight stays, in Sweden. Using municipal-level data for the period 1998–2015, we perform a quantitative analysis using ordinary least squares (OLS) as well as panel-data methods that take unobserved heterogeneity between municipalities i

As the most common type of defects in WO3, surface oxygen deficiencies have been widely investigated in terms of their structure as well as physicochemical properties. In general, oxygen vacancy on the surface may lead to the reconstruction of the surface structure due to the need for surface energy minimization, especially for the area with high oxygen vacancy concentration. However, such a pheno

Fjärrvärme och fjärrkyla är ändamålsenliga system för distribution av värme och kyla i tätbebyggda områden. Dessa system är viktiga vid planeringen av framtida energieffektiva system på grund av deras höga potential för att integrera förnybara energikällor. Systemen spelar också en viktig roll i samhällets energiförsörjningssäkerhet, vilket gör dem till ett tvärvetenskapligt forskningsområde. Den District heating and cooling are efficient systems for distributing heat and cold in urban areas. They are a key solution for planning future urban energy-efficient systems due to their high potential for integrating renewable energy sources. The systems also play an important role in community resilience, which makes them a multidisciplinary research topic. The continuous development of these sys

The literature on catch-up cycles has not yet systematically conceptualized how catch-up dynamics differ between the various industries that are emerging in the green techno-economic paradigm. We address this gap by connecting catch-up cycle theory with an industry typology from global innovation systems (GISs) literature, which distinguishes four generic industry types with footloose, spatially s

Aim: Depression is common and rising in adolescents. Recent meta-analyses indicate a moderate effect of exercise on depression symptoms. Clinically referred adolescents and their experiences of an exercise intervention have rarely been studied. The aim of this study was to describe clinically referred adolescents’ experience of moderate to vigorous exercise as a treatment for depression. Methods: