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Microglia are activated in many neurological diseases and have been suggested to play an important role in the development of affective disorders including major depression. To investigate how microglial signaling regulates mood, we used bidirectional chemogenetic manipulations of microglial activity in mice. Activation of microglia in the dorsal striatum induced local cytokine expression and a ne

Antiarrhythmic effects of melatonin have been demonstrated ex vivo and in rodent models, but its action in a clinically relevant large mammalian model remains largely unknown. Objectives of the present study were to evaluate electrophysiological and antiarrhythmic effects of melatonin in a porcine model of acute myocardial infarction. Myocardial ischemia was induced by 40-min coronary occlusion in

For decades, inshore commercial fisheries of Sweden have declined in the number of fishermen. In parallel, the service economy has gained importance and the growth in tourism is one example. This implicates new conditions for small firms, active in traditional rural industries. While knowledge about the socio-cultural context of small tourism firms is underdeveloped and since policymaking assigns

To map out the state of the art of comparative studies of Internet use and recognize the contributions and shortcomings in the current literature, we have used a four-dimension framework to conduct a review of journal articles indexed in the Social Sciences Citation Index (SSCI) in the field of communication studies in the Web of Science core collection between 1969 and 2019. Our findings describe

When performing acoustic simulations with the purpose of auralization, there is a trade-off between accuracyand speed. In real-time simulations of virtual reality, finding the balance of this trade-off is paramount to achiev-ing the desired result. If successful, the simulation speed is sufficient to provide a seamless acoustic experienceas the agent moves around the space, while still being accur

The observation of forward proton scattering in association with lepton pairs (e+e−+p or μ+μ−+p) produced via photon fusion is presented. The scattered proton is detected by the ATLAS Forward Proton spectrometer, while the leptons are reconstructed by the central ATLAS detector. Proton-proton collision data recorded in 2017 at a center-of-mass energy of √s=13 TeV are analyzed, corresponding to an

The European Spallation Source (ESS), which is under construction in Lund (Sweden), will be the next leading neutron facility with an unprecedented brilliance and novel long-pulse time structure. A long-pulse source not only provides a high time-average flux but also opens the possibility to tune the resolution by using pulse shaping choppers. Thus, an instrument can readily be operated in either

Here we present recent advances and applications of profiling biological targets with Scheimpflug lidar. In particular we demonstrate applications for profiling the aerofauna and classifying various groups of species. Based on lidar data over the Ivorian countryside we investigate range dependent detection limits by comparing data with distinct sample rates and pulse energies.

Fundamental limits on scattering metrics such as absorption, extinction, and Purcell's factor are formulated by separating a scattering structure into controllable and uncontrollable regions. We present each bound as a special case of a general methodology based on the method of moments and convex optimization.

Systems mixing Boolean logic and arithmetic have been a long-standing challenge for verification tools such as SAT-based bit-vector solvers. Though SAT solvers can be highly efficient for Boolean reasoning, they scale poorly once multiplication is involved. Algebraic methods using Gröbner basis reduction have recently been used to efficiently verify multiplier circuits in isolation, but generally

Elastic fibers containing elastin play an important role in tendon functionality, but the knowledge on presence and function of elastin during tendon healing is limited. The aim of this study was to investigate elastin content and distribution in intact and healing Achilles tendons and to understand how elastin influence the viscoelastic properties of tendons. The right Achilles tendon was complet

Objectives: Risk of multiple sclerosis (MS) is low among first-generation immigrants in Sweden. We aimed to study incident MS in first- and second-generation immigrant groups. Materials & Methods: We included adults aged 18 years and older in Sweden in first-generation (n = 6 042 891) and second-generation (n = 4 860 469) sub-studies. MS was defined via two diagnoses in the Swedish National Pa

Background: Over half of children with rare genetic diseases remain undiagnosed despite maximal clinical evaluation and DNA-based genetic testing. As part of an Undiagnosed Diseases Program applying transcriptome (RNA) sequencing to identify the causes of these unsolved cases, we studied a child with severe infantile osteopetrosis leading to cranial nerve palsies, bone deformities, and bone marrow

The source region of the Yangtze River (SRYR), the origin of the longest river in China, is an area with high-mountains and river ecotones that face considerable challenges under climate change. Precipitation is fundamental for sustainable ecosystems in this area and for the downstream water supplies. Thus, this study investigated the present and future patterns of precipitation variation in the S