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Objective: To investigate the feasibility of using neutron tomography to gain new knowledge of human articular cartilage degeneration in osteoarthritis (OA). Different sample preparation techniques were evaluated to identify maximum intra-tissue contrast. Design: Human articular cartilage samples from 14 deceased donors (18–75 years, 9 males, 5 females) and 4 patients undergoing total knee replace
Harp seals (Phoca groenlandicus), once present in the Baltic Sea, now stand extinct. During the Middle Neolithic period, they held significant dietary importance for the Pitted Ware Culture hunter-fisher-gatherers in Scandinavia. Because they are no longer available for ecological studies, little is known about their specific behavioural intricacies, such as diet, mobility, and reproductive strate
Objective: Interactive patient education, referred to as Heart School (HS), is an important part of cardiac rehabilitation (CR) after myocardial infarction (MI), which has been associated with improved outcomes. Little is known about HS attendance among foreign-born patients. The aims were to assess; 1) HS attendance in foreign-born versus native-born patients, 2) the association between the provi
Purpose: The purpose of this systematic review is to critically analyse pharmaceutical industry case studies on the implementation of Lean 4.0 methodologies to synthesize key lessons, benefits, and best practices. The goal is to inform decisions and guide investments in related technologies for enhancing quality, compliance, efficiency and responsiveness across production and supply chain processe
The anomalous Lagrangian in mesonic Chiral Perturbation Theory, of odd intrinsic parity, is determined to next-to-next-to-leading order thereby completing the order p8 Lagrangian. A schematic view of its construction with the MINIBAR package for Mathematica is presented and the final operator count is discussed for a general number of light quark flavours as well as for the physical cases N f = 2,
Divergent ecological adaptation resulting from selection is common, but how often it results in differentiation that can last in the face of gene flow is debated. Reproductive barriers persistent to stochastic environmental change are key for species to form. Hence, how ecological adaptation is coupled to reproductive isolation is key for understanding ecological speciation. Lineages that are both
Articular cartilage and meniscus transfer and distribute mechanical loads in the knee joint. Degeneration of these connective tissues occurs during the progression of knee osteoarthritis, which affects their composition, microstructure, and mechanical properties. A deeper understanding of disease progression can be obtained by studying them simultaneously. Time-resolved synchrotron-based X-ray pha
We have employed both unpaired (cranked Nilsson-Strutinsky) and paired (cranked Nilsson-Strutinsky-Bogoliubov) cranked Nilsson-Strutinsky calculations to explore the properties of observed and potential isomers within the shape-transitional osmium (Z=76) isotopes and N=116 isotones. Our analyses reveal the prevalence of multiquasiparticle prolate and broken-pair triaxial structures in even-even os
The gaseous envelope of an accreting rocky planet becomes hot enough to sublimate silicates and other refractory minerals. For this work, we studied the effect of the resulting envelope enrichment with a heavy vapor species on the composition and temperature of the envelope. For simplification, we used the gas-phase molecule SiO to represent the sublimation of silicate material. We solved the equi
The effective conversion of carbon dioxide (CO2) into valuable chemical fuels relies significantly on the donation of multiple electrons. Its efficiency is closely linked to both the density and lifetime of excited charge carriers. In this study, a hybrid catalyst system comprising covalently bonded InP/ZnS quantum dots (QDs) and Re-complexes is showcased. The electronic band alignment between the
Quantum chromodynamics (QCD), the basic theory of strong interactions between the quarks and gluons is expected to play an important role in the early universe. We discuss the scenario when the fast cooling of QCD matter leads to the creation of a saturated phase with an enormous number of possible configurations. Using an analogy with the classical glasses we predict that this glassy form of matt
Laser diagnostics has been one of the most powerful tools in advancing state-of-the-art combustion research over the last five decades. Prof. Marcus Aldén, one of the most well-known pioneers in this field, has contributed many influential original publications over more than 40 years of his research career. In this paper, we will review some selected contributions, with emphasis on optical techni
Background and Objective: Coeliac disease is a chronic, immune-mediated disorder for which the only treatment consists of lifelong strict adherence to gluten-free diet (GFD). However, there is a lack of evidence-based guidelines on the GFD dietary management of coeliac disease. This position paper, led by the Special Interest Group in coeliac disease of the European Society of Pediatric, Gastroent
Background: Knowledge is sparse on the impact of type 2 diabetes (T2D) on surgical outcomes after breast cancer surgery. This study investigated the association between T2D and risk of complications after primary breast cancer surgery, and evaluated the biological interaction between T2D and co-morbidities. Methods: Using the Danish Breast Cancer Group clinical database, a cohort of all Danish wom
Organisms inhabiting extreme thermal environments, such as desert birds, have evolved spectacular adaptations to thermoregulate during hot and cold conditions. However, our knowledge of selection for thermoregulation and the potential for evolutionary responses is limited, particularly for large organisms experiencing extreme temperature fluctuations. Here we use thermal imaging to quantify select
Background: Persons on the autism spectrum exhibit poorer body awareness than neurotypical persons. Since movement quality may be regarded as an expression of body awareness, assessment of movement quality is important. Sound assessments of measurement properties are essential if reliable decisions about body awareness interventions for persons on the autism spectrum are to be made, but there is i
Work is central to people’s lives and the course of their life. The opportunities and chances an individual can have in their life are significantly connected to work. Individuals' work is also crucial for organisations, companies and for the whole of society. There is a constant need to make changes and readjustments of working life since these can deeply affect the individual and their employabi
Infant and adult MLL1/KMT2A-rearranged (MLLr) leukemia represents a disease with a dismal prognosis. Here, we present a functional and proteomic characterization of in utero-initiated and adult-onset MLLr leukemia. We reveal that fetal MLL::ENL-expressing lymphomyeloid multipotent progenitors (LMPPs) are intrinsically programmed towards a lymphoid fate but give rise to myeloid leukemia in vivo, hi
