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Machining of Titanium Alloys with a Cemented Carbide Cutting Tools with Tungsten-Based Vacuum-Arc Nitride Coatings

Finding the right coatings for cutting tools is essential in order to increase the tool wear resistance and, thus, to get better surface roughness for the machined workpieces, and to improve productivity. A coating requirements are not only its mechanical and strength properties, but also its response to a given load and a given wear exposure. To expand ideas about the phenomena and mechanisms of

Wear mechanisms in Ti(C,N)-Al2O3 coated carbide during sustainable machining CGI

By replacing conventional gray cast iron (GI) with compacted graphite iron (CGI), automotive industry could keep up with stricter regulations on emissions and demands on higher engine performance. CGI has improved properties as to GI but is more difficult to machine. This study evaluates sustainable machining performance during finish face milling when using minimum quantity lubrication applied ve

Association of beta-blockers beyond 1 year after myocardial infarction and cardiovascular outcomes

Objective Beta-blockers (BB) are an established treatment following myocardial infarction (MI). However, there is uncertainty as to whether BB beyond the first year of MI have a role in patients without heart failure or left ventricular systolic dysfunction (LVSD). Methods A nationwide cohort study was conducted including 43 618 patients with MI between 2005 and 2016 in the Swedish register for co

Veiled Integration : The Use of Headscarves among a Christian Minority in Sweden

In this article, we trace a specific ‘situated bodily practice’, namely the ‘act of covering’ the head with a scarf during liturgy, in a church that has migrated from the Middle East to Sweden. This ‘veiled tradition’ is interpreted as a ‘ritual of migration’ that can cast light on the complexities of re-producing traditions in a new setting, functioning as a ‘cultural prism’ for the question of i

Football training as a non-pharmacological treatment of the global aging population—A topical review

In the present topical mini-review, the beneficial impact of small-sided game football training for the increasing elderly global population is presented. As a multicomponent type of physical activity, football training executed on small pitched with 4–6 players in each team is targeting a myriad of physiological systems and causes positive adaptations of relevance for several non-communicable dis

DeepLSD : Line Segment Detection and Refinement with Deep Image Gradients

Line segments are ubiquitous in our human-made world and are increasingly used in vision tasks. They are complementary to feature points thanks to their spatial extent and the structural information they provide. Traditional line detectors based on the image gradient are extremely fast and accurate, but lack robustness in noisy images and challenging conditions. Their learned counterparts are more

A cooperation experiment with white-handed gibbons (Hylobates lar)

Cooperative behaviors among individuals of numerous species play a crucial role in social interactions. There is a special interest in investigating the occurrence of cooperation among apes because this knowledge could also shed light on evolutionary processes and help us understand the origin and development of cooperation in humans and primates in general. Gibbons are phylogenetically intermedia

Tau-neurodegeneration mismatch reveals vulnerability and resilience to comorbidities in Alzheimer's continuum

INTRODUCTION: Variability in relationship of tau-based neurofibrillary tangles (T) and neurodegeneration (N) in Alzheimer's disease (AD) arises from non-specific nature of N, modulated by non-AD co-pathologies, age-related changes, and resilience factors. METHODS: We used regional T-N residual patterns to partition 184 patients within the Alzheimer's continuum into data-driven groups. These were c

Revealing Precipitate Development During Hot Rolling and Cooling of a Ti–Nb Micro-Alloyed High Strength Low-Alloy Steel through X-Ray Scattering

High-energy synchrotron X-ray small-angle scattering (SAXS) is used to study the precipitate development during hot rolling and cooling of a commercial Ti–Nb micro-alloyed, high-strength, low-alloy (HSLA) steel. To study precipitation during hot rolling conditions, Gleeble and dilatometer trials are made. Samples are then studied at room temperature using SAXS in conjunction with transmission elec

Low-level exposure to lead and atherosclerosis in the carotid arteries : Results from the Swedish population-based cohort SCAPIS

Background: Lead exposure is associated with cardiovascular disease. Atherosclerosis has been hypothesized to be one of the underlying mechanisms behind this association. Aim: To investigate whether lead exposure is associated with an increased risk of atherosclerosis in the carotid arteries in a large Swedish population-based cohort. Methods: We performed a cross-sectional study using data from t

Functional convergence of genomic and transcriptomic architecture underlies schooling behaviour in a live-bearing fish

The organization and coordination of fish schools provide a valuable model to investigate the genetic architecture of affiliative behaviours and dissect the mechanisms underlying social behaviours and personalities. Here we used replicate guppy selection lines that vary in schooling propensity and combine quantitative genetics with genomic and transcriptomic analyses to investigate the genetic bas

Cardiovascular Effects of GnRH Antagonists Compared With Agonists in Prostate Cancer : A Systematic Review

Background: Androgen deprivation therapy is the cornerstone of treatment for patients with advanced prostate cancer. Meta-analysis of small, oncology-focused trials suggest gonadotropin-releasing hormone (GnRH) antagonists may be associated with fewer adverse cardiovascular outcomes compared with GnRH agonists. Objectives: This study sought to determine whether GnRH antagonists were associated wit

Outcomes of rescue procedures in the management of locally recurrent ampullary tumors : A Pancreas 2000/EPC study

Background: Ampullary lesions are rare and can be locally treated either with endoscopic papillectomy or transduodenal surgical ampullectomy. Management of local recurrence after a first-line treatment has been poorly studied. Methods: Patients with a local recurrence of an ampullary lesion initially treated with endoscopic papillectomy or transduodenal surgical ampullectomy were retrospectively i

Precision medicine for cardiometabolic disease : a framework for clinical translation

Cardiometabolic disease is a major threat to global health. Precision medicine has great potential to help to reduce the burden of this common and complex disease cluster, and to enhance contemporary evidence-based medicine. Its key pillars are diagnostics; prediction (of the primary disease); prevention (of the primary disease); prognosis (prediction of complications of the primary disease); trea

Numerical study on liquid ammonia direct injection spray characteristics under engine-relevant conditions

This paper reports on CFD modeling of the fuel/air mixing characteristics of liquid ammonia under direct injection engine-relevant conditions. Several questions are addressed including, whether the widely used Lagrange particle tracking (LPT) spray models developed for traditional fossil fuels are suitable for ammonia spray, whether certain improvement of the current models should be introduced, a

The estimated effect of season and vitamin D in the first trimester on pubertal timing in girls and boys : A cohort study and an instrumental variable analysis

Background: Season of birth has been associated with age at menarche. Maternal vitamin D levels in pregnancy may explain this effect. We investigated whether the season of first trimester or maternal 25-hydroxyvitamin D3 [25(OH)D3] levels were associated with pubertal timing in children. Methods: We conducted a follow-up study of 15 819 children born in 2000-03 from the Puberty Cohort, nested in t

Non-Motor Symptom Management : Insights into Adherence to Treatment Guidelines in Parkinson’s Disease Patients

Background:Non-motor symptoms (NMS) reduce quality of life in Parkinson’s disease (PD) patients, who experience three times more NMS than individuals without PD. While there are international and national NMS treatment guidelines, their implication in clinical practice remains unclear.Objective:This study aimed to investigate the adherence to pharmacological NMS treatment guidelines in patients wi

Membrane processes in fruit juice production

Fruit juices are a key global beverage with an increasing market and membrane processes are key processes in fruit juice processing. The most established membrane processes are the pressure-driven processes: microfiltration and ultrafiltration for the clarification the juices plus nanofiltration and reverse osmosis the concentration/pre-concentration of the juices. Additionally, the potential of t