BACKGROUND: Several therapies are available for psoriasis, including in some countries oral fumaric acid derivatives (FADs). Even if FADs are not available in the Italian market, they can be prescribed and reimbursed by the National Health Service, on request from the treating physician, when considered as a valuable option in selected patient.METHODS: We performed a retrospective analysis of the

Necrobiosis lipoidica diabeticorum (NLD) is a chronic condition, which is characterized by single or multiple lesions on the legs, and occurs in 0.3% of patients with diabetes. Recently, platelet-rich plasma (PRP) has been used in several clinical settings to promote sustained healing and better outcome. We propose the use of PRP for the treatment of NLD-associated recalcitrant wounds. In this stu

Fat Embolism Syndrome (FES) is a rare and often lethal condition, associated with trauma or surgery. It is more serious than a typical fat embolism seen after a fracture in a long bone. FES is a triad of symtoms, including respiratory failure, abnormal neurology and petechial bleeding. FES is a diagnosis of exclusion. The incidence of FES is higher among adults compared to children. One possible e

Electric vehicles have recently garnered significant attention in the research community due to their potential has a large, highly controllable load which can be used in demand response, load shaping, and renewable energy integration. However, research into practical charging algorithms has been hampered by the lack of a widely available, realistic simulation environment. To meet this need in the

Limits are set on the pair production of scalar leptoquarks, where all possible decays of the leptoquark into a quark (t, b) and a lepton (τ, ν) of the third generation are considered. The limits are presented as a function of the leptoquark mass and the branching ratio into charged leptons for up-type (LQ3 u → tν/bτ) and down-type (LQ3 d → bν/tτ) leptoquarks. Many results are reinterpretations of

This commentary on Wooffitt’s lucid article discusses three major implications of the phenomenon of poetic confluences or ESP puns to our understanding of minds and selves. The first reinforces the view of mind as associative and metaphorical, rather than merely computational. The second reviews various strands of evidence, including experimental research on psi phenomena, to reveal that selves an

The problem of estimating receiver or sender node positions from measured receiver-sender distances is a key issue in different applications such as microphone array calibration, radio antenna array calibration, mapping and positioning using UWB or using round-trip-time measurements between mobile phones and WiFi-units. In this paper we address the problem of optimally estimating a receiver positi

In this paper optimal spectral analysis window shapes, using weighted discrete prolate spheroidal sequences as basis functions, are proposed. These windows are not typically positive or even. The windows are time-shifted, combining the computational efficiency of the Welch method and the appealing property of predefined frequency resolution of the Thomson spectral estimator. The parameters of the

We analyze the sensitivity of hadronic τ decays to nonstandard interactions within the model-independent framework of the standard model effective field theory. Both exclusive and inclusive decays are studied, using the latest lattice data and QCD dispersion relations. We show that there are enough theoretically clean channels to disentangle all the effective couplings contributing to these decays

Background: Oncoplastic breast-conserving surgery allows larger resections in unfavorable locations, with an improved chance of preserving esthetics. Indications and timing for potential contralateral surgery to obtain symmetry are not clear. The aim of this study was to evaluate patient satisfaction after unilateral oncoplastic volume displacement surgery, to investigate potential risk factors fo

Background: Little is known regarding the burden of comorbidities among older people with intellectual disability (ID) who have affective and anxiety disorders. Therefore, we aimed to investigate the occurrence and risk of psychiatric and somatic comorbidities with affective and/or anxiety disorders in older people with ID compared to the general population. Methods: This population study was base

Introduction: Inherited susceptibility to lung cancer risk in never-smokers is poorly understood. The major reason for this gap in knowledge is that this disease is relatively uncommon (except in Asians), making it difficult to assemble an adequate study sample. In this study we conducted a genome-wide association study on the largest, to date, set of European-descent never-smokers with lung cance

In this paper we study the problem of estimating receiver and sender positions from time-difference-of-arrival measurements, assuming an unknown constant time-difference-of-arrival offset. This problem is relevant for example for repetitive sound events. In this paper it is shown that there are three minimal cases to the problem. One of these (the five receiver, five sender problem) is of particul

The number of publications in the field of chemical cross-linking combined with mass spectrometry (XL-MS) to derive constraints for protein three-dimensional structure modeling and to probe protein-protein interactions has increased during the last years. As the technique is now becoming routine for in vitro and in vivo applications in proteomics and structural biology there is a pressing need to

In this study the structured laser illumination planar imaging (SLIPI) technique is combined with gas phase phosphor thermometry to measure quasi-instantaneously two-dimensional temperature fields with reduced bias from multiple scattering. Different reconstruction strategies are implemented, evaluated and compared, including a two-pulse and one-pulse SLIPI approach. A gradient-based threshold alg