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Protein rib: a novel group B streptococcal cell surface protein that confers protective immunity and is expressed by most strains causing invasive infections

The group B Streptococcus, an important cause of invasive infections in the neonate, is classified into four major serotypes (Ia, Ib, II, and III) based on the structure of the polysaccharide capsule. Since the capsule is a known virulence factor, it has been extensively studied, in particular in type III strains, which cause the majority of invasive infections. Two cell surface proteins, alpha an

Indoor Environmental Factors and its Associations with Asthma and Allergy Among Swedish Pre-School Children

Popular Abstract in Swedish En mängd epidemiologiska studier har visat att fuktskador i bostaden eller på arbetsplatsen ökar risken för olika typer av hälsobesvär, t.ex. astmatiska och allergiska besvär. Exakt vad som emitteras och orsakar dessa symptom i fuktskadade byggnader är inte känt, men både kemiska och mikrobiologiska agens är misstänkta. Vidare finns behov av bättre metoder för att identIt has been shown in a large number of scientific studies that living or working in a building with mould and moisture damage increases the risk for asthmatic and allergic symptoms. However, there is a need to establish more valid methods to obtain a more nuanced picture of the wide range of different types of moisture related problems. Furthermore, the causal relationships and the biological mech

H-2(He-3, t)2p reaction at 2 GeV

The exclusive H-2 (He-3, t)2p reaction has been studied at 2 GeV for energy transfers up to 500 MeV and triton angles up to 3.4degrees. The protons were measured in the large acceptance magnetic detector DIOGENE, in coincidence with the forward tritons detected in a dedicated magnetic arm. The energy transfer spectra extend well above the pion threshold. However, in the region of Delta excitation,

Hereditary Ovarian Cancer mutation frequencies and genetic profiles

Popular Abstract in Swedish Identifiering av ärftlig äggstockscancer har stor klinisk relevans för att förhindra nya tumörer hos individen och i familjen. Möjligheten att förhindra bröstcancer i BRCA familjer genom kontrollprogram och profylaktisk kirurgi är välkänd, medan möjligheten att förhindra tarmcancer och livmodercancer i HNPCC familjer är mindre känd. Studierna i denna avhandling har kunnOvarian cancer is a leading cause of gynecological cancer death and in Sweden nearly 700 cases are diagnosed annually. Ovarian cancer has one of the highest frequencies of hereditary cancer. This thesis focuses on estimates of the contribution of hereditary breast and ovarian cancer (HBOC) and hereditary nonpolyposis colorectal cancer (HNPCC) to the development of ovarian cancer and investigates t

Theoretical and Experimental Studies of the Formation of Ionized Gases in Spark Ignition Engines

Popular Abstract in Swedish Denna studie är ämnad åt att undersöka joniseringsprocessen i gaser, både teoretiskt och experimentellt. Arbetet är speciellt riktat mot att utöka förståelsen för detta fenomen i förbränningsrummet av en förbränningsmotor. Den intensiva joniseringsprocessen som uppstår till följd av den antändande gnistan har studerats såväl som den svagare joniseringsprocessen som är rThe processes that govern the formation, existence and consumption of ions in gases have been studied both experimentally and theoretically. The aim of the work is targeted at increasing the understanding of these phenomena in the working gases inside an engine. Both the cause and the application of ionized gases inside the cylinder of a spark ignited (SI) engine has been studied. The spark disch

Buda-Lund hydro model for ellipsoidally symmetric fireballs and the elliptic flow at RHIC

The ellipsoidally symmetric extension of Buda-Lund hydrodynamic model is shown here to yield a natural description of the pseudorapidity dependence of the elliptic flow upsilon(2)(eta)), as determined recently by the PHOBOS experiment for Au + Au collisions at root(S)NN = 130 and 200 GeV. With the same set of parameters, the Buda-Lund model describes also the transverse momentum dependence of upsi

Cyclic adenosine monophosphate stimulation of mucociliary activity in the upper airways in vivo

Xanthine derivatives are known to accelerate mucociliary transport in the lower airways, probably by preventing degradation of cyclic adenosine monophosphate (cAMP) and thereby increasing its intracellular concentration. The purpose of this study was to investigate the effects of cAMP on mucociliary activity in the upper airways. The effect on the mucociliary activity in the rabbit maxillary sinus

Molecular mapping of epitopes involved in ligand activation of the human receptor for the neuropeptide, VIP, based on hybrids with the human secretin receptor

Receptors for the neurotransmitter and neuroendocrine peptides, vasoactive intesinal peptide (VIP) and secretin, both belong to the Type B subfamily of G-protein-coupled receptors. This group is evolutionally as well as structurally distinct from the much larger Type A, or rhodopsin-type, subfamily. We have mapped the ligand-activating epitopes of the human VIP1 receptor by the use of hybrid recep

Assimilation or coarticulation? Evidence from the coordination of tongue gestures for the palatalization of Bulgarian alveolar stops.

Three issues are considered in this report —are assimilation and coarticulation the same process or different, are they achieved by feature spreading or by coproduction, and what level or levels of neuromotor planning or production do they represent? Tongue gestures analysed from an X-ray motion film of Bulgarian speech are presented as examples of what the tongue is made to do in speech and of ho

ELISA on a microchip with a photodiode for detection of amphetamine in plasma and urine

A rapid and sensitive assay was developed for the detection of amphetamine in plasma and urine. The method relies on the principle of competitive ELISA (enzyme-linked immunosorbent assay). A flow microchip with a total volume of 7 µL was used for the development of a chemiluminescent ELISA technique. Solutions, samples, and the chemiluminescence substrate were injected by a flow system, and a phot

Associations of dietary fiber with glucose metabolism in nondiabetic relatives of subjects with type 2 diabetes - The Botnia Dietary Study

OBJECTIVE - To study cross-sectional associations of dietary fiber intake with insulin resistance, insulin secretion, and glucose tolerance in a population at high risk for type 2 diabetes. RESEARCH DESIGN AND METHODS - The subjects consisted of 248 male and 304 female adult nondiabetic relatives of patients with type 2 diabetes. Dietary intake was measured by means of two 3-day food records. Asso

Gender and strain influence on neurogenesis in dentate gyrus of young rats

To investigate whether rat hippocampal neurogenesis varies with strain and gender, the authors examined proliferating progenitor cells and their progeny in young male and female Sprague-Dawley (SD) and spontaneously hypertensive rats (SHR) using the thymidine analog bromodeoxyuridine (BrdU) combined with immunohistochemistry for the neuronal marker Calbindin D28k and glial fibrillary acidic protei

Oligomeric acylphloroglucinols from myrtle (Myrtus communis)

The dimeric nonprenylated acylphloroglucinol semimyrtucommulone (6) was obtained from the leaves of. myrtle (Myrtus communis) as a 2:1 mixture of two rotamers. The known trimeric phloroglucinol myrtucommulone A (1) was also isolated and characterized spectroscopically as a silylated cyclized derivative (5). Myrtucommulone A showed significant antibacterial activity against multidrug-resistant (MDR

Speech presence detection in the time-frequency domain using minimum statistics

The contribution of this paper is a time-frequency domain speech presence detection method that classifies power bins in the time-frequency domain as containing speech or not. An initial decision rule is based on ratios between optimally time-smoothed signal-plus-noise periodograms and weighted noise periodogram estimates, obtained from minimum statistics as proposed by Martin [1]. The initial dec