Personalized medicine requires the integration and processing of vast amounts of data. Here, we propose a solution to this challenge that is based on constructing Digital Twins. These are high-resolution models of individual patients that are computationally treated with thousands of drugs to find the drug that is optimal for the patient.

Svenska politiker ”mörkar” när det gäller frågan om vad vi faktiskt betalar i skatt. Det handlar om ett demokratiskt informationsunderskott som inte är värdigt ett samhälle som gör anspråk på öppenhet i det offentliga samtalet. Nu måste beslut fattas om att alla lönebesked redovisar såväl totallön, löneskatt och löneavgifter, som bruttolön, inkomstskatt och nettolön. Fiffiga finansministrar har hi

På många utbildningar är det idag vanligt att det finns en uppdragsgivare som står bakom ett examensarbete. Det kan vara ett företag, en förvaltning, en branschorganisation eller liknande. Denna nya situation kan vara både utmanande och stimulerande.I boken presenteras på ett enkelt sätt olika metodfrågor och logiken bakom olika metodkrav förklaras. Frågor som: varför måste det finnas källhänvisni

Purpose: Children and adolescents with primary headache are at risk of persistent somatic symptoms and reduced quality of life (Qol) due to pain and pain-related behaviors, such as avoiding school and activities. Sleep is essential to health, and children and adolescents with primary headaches have more sleep complaints than do healthy controls. A treatment approach that addresses multifactorial c

This a contribution to the cultural semiotics of African cultural encounters seen through the eyes of Swedish naturalists at the end of the eighteenth century. European travellers faced severe problems in understanding the alien African cultures they encountered; they even had difficulty understanding the other culture as a culture. They were not just other cultures that they could relate to, but

OBJECTIVE: There are historical and theoretical indications of a difference in subjective experience between autism spectrum disorder (ASD) and the schizophrenia spectrum. However, this difference has not been empirically explored. Therefore, to explore potential differences in subjective experience between the 2 spectra, we examined the presence/absence of self-disorders in Asperger syndrome/auti

Solid state klystron modulators are typically based on oil-immersed pulse transformers due to their high performance, robustness, simplicity and straightforward design. However, the size of such transformers are highly impacted by pulse power, output voltage, pulse length, and required rise time; key parameters which are difficult to combine in long pulse high power linac applications. In this pap

Lately, evidence for early-Holocene emerging sedentism has been suggested among foragers in Northern Europe. The core of this suggested sedentism lies in the increasing dependency on large-scale fishing and mass consumption of fish and a territorial behaviour associated with access to the best fishing locations. This territoriality might also be associated with increasing numbers of people settlin

Traditionally, the room acoustic properties in an ordinary public room are defined by only one parameter, the reverberation time. However, research has showed that additional room acoustic parameters as sound strength and speech clarity are necessary to consider in order to achieve good acoustic conditions. In a room with acoustical ceiling treatment the effects of furniture and interiors on the r

According to a recent conjecture in the literature, earnings have become a poorer proxy for cash flow from operations over time. We find that since 1988, when cash flow statements started to be consistently reported in Compustat, the cash effectiveness of earnings has actually increased for a large sample of U.S. manufacturing firms. This occurs despite the introduction of fair value accounting an

This paper investigates trends in the study of Modern languages or second foreign languages (SFLs) in Swedish lower secondary school between 2000 and 2018. Over the last decades, SFLs, i.e. French, German and Spanish, have been the target of several policy measures as a response to a declining interest. However, few reports on their impact have been published. We report the proportion of pupils st

A novel technique for studies of the dynamics of molecular coherences has been developed. The concept is based on prompt excitation using broadband femtosecond (fs) laser pulses, whereupon a narrowband nanosecond (ns) laser pulse probes the fast dynamics of the coherences. Detection of the spectrally dispersed coherent signal using a streak camera allows simultaneous spectrally and temporally reso