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Uric Acid Levels Have No Significant Effect on Renal Function in Adult Renal Transplant Recipients: Evidence from the Symphony Study.

BACKGROUND AND OBJECTIVES: Uric acid (UA) has been linked to renal damage in experimental models of kidney failure. In humans, no definitive link between UA and renal function has been established, but several epidemiologic studies have suggested that higher UA levels are associated with accelerated loss of renal function, higher incidence of dialysis, and death. Many of the associations have been

Simulation of Multibody Systems by a Parallel Extrapolation Method

In the simulation of multibody systems, the equations of motion are generated by so-called multibody formalisms as a system of differential-algebraic equations (DAEs). A recently developed extrapolation method for integrating the equations of motion is investigated. Extrapolation methods for ordinary differential equations are briefly reviewed, before proceeding to the DAE method. The inherent par

Endovascular treatment for chronic type B dissection: limitations of short stent-grafts revealed at midterm follow-up.

PURPOSE: To examine the incidence of and the indications for re-intervention, as well as the changes in aortic morphology, in patients with chronic type B aortic dissection who underwent endovascular intervention for false lumen aneurysms. METHODS: A retrospective analysis was conducted of 10 patients (8 men; mean age 63 years, range 45-79) who underwent stent-graft repair of aneurysmal false lume

A conceptual fatigue-motivation model to represent pedestrian movement during stair evacuation

Evacuation models often neglect the impact of fatigue on pedestrian movement during stair evacuation. While a limited number of sub-models are available in the literature to represent fatigue during evacuations, they mostly refer to simple, fixed walking speed reductions due to physical fatigue. This paper introduces a more comprehensive conceptual model for the representation of the impact of fat

Optimal management of metastatic renal cell carcinoma: an algorithm for treatment.

The treatment of metastatic renal cell carcinoma (mRCC) has been changed by the introduction of targeted agents. Consideration of individual patient factors, such as previous treatment and prognostic risk, e.g. according to the Memorial Sloan-Kettering Cancer Center (MSKCC) risk criteria), can assist in ensuring that patients receive appropriate targeted therapies. Available clinical evidence show

The tyrosine sulfate rich domains of the LRR-proteins fibromodulin and osteoadherin bind motifs of basic clusters in a variety of heparin binding proteins including bioactive factors.

The small leucine-rich repeat proteins (SLRPs), fibromodulin and osteoadherin, have N-terminal extensions with a variable number of O-sulfated tyrosine residues. This modification combined with a number of aspartic and glutamic acid residues results in a highly negatively charged domain of less than 30 amino acids. We hypothesized that this domain shares functional properties with heparin regardin

Medical Diagnostic System Based On Simultaneous Multispectral Fluorescence Imaging

A multicolor fluorescence imaging system applied to medical diagnostics is described. The system presented simultaneously records four fluorescence images in different wavelength bands, permitting low-resolution spectroscopy imaging. An arithmetic function image of the four spectral images is constructed by a pixel-to-pixel calculation and is presented on a monitor in false-color coding. A sensiti

Capturing all disease-causing mutations for clinical and research use: toward an effortless system for the Human Variome Project.

The collection of genetic variants that cause inherited disease (causative mutation) has occurred for decades albeit in an ad hoc way, for research and clinical purposes. More recently, the access to collections of mutations causing specific diseases has become essential for appropriate genetic health care. Because information has accumulated, it has become apparent that there are many gaps in our

Remediation of mould damaged building materials-efficiency of a broad spectrum of treatments.

We compared the efficiency of some commercially available products and methods used for remediation of mould-contaminated building materials. Samples of gypsum board and pinewood were artificially contaminated with toxin-producing isolates of Stachybotrys chartarum and Aspergillus versicolor, respectively, then, ten different remediation treatments were applied according to the manufacturers' inst

Surface microdialysis sampling: a new approach described in a liver ischaemia model.

We recently have shown that samples from microdialysis (MD) probes placed on the surface of the heart reflect metabolic events in the myocardium. This new interesting observation challenges us to consider whether surface application of MD applies to other parenchymatous organs and their surfaces. In 13 anesthetized pigs, transient liver ischaemia was achieved by occlusion of arterial and venous in

Androgen Receptor Genotype in Humans and Susceptibility to Endocrine Disruptors.

Although animal studies have raised concern that the influence of endocrine-disrupting compounds would obstruct the development of the male reproductive system, in general, exposure levels far above those found in humans have been needed to induce reproductive toxicity in animal models. Human data are inconclusive and have evoked the question whether endocrine-disrupting compounds can have any imp

Strategy for identification and detection of multiple oxidative modifications within proteins applied on persulfate-oxidized hemoglobin and human serum albumin.

Oxidative stress has been suggested as an underlying mechanism of many human diseases. However, definitive evidence for this association has not been presented due to different shortcomings of the methods used to measure biomarkers of oxidative stress. Persulfates are oxidizing agents known to elicit hypersensitive reactions from the airways and skin. Despite a frequent use of persulfates at many

Endogenous antimicrobial peptide LL-37 induces human vasodilatation.

BACKGROUND: /st> Septic shock includes blood vessel dilatation and activation of innate immunity, which in turn causes release of antimicrobial peptides such as LL-37. It has been shown that LL-37 can attract leucocytes via the lipoxin A(4) receptor (ALX, FPRL1). ALX is also present in vascular endothelial cells. To explore possible ways of pharmacological intervention in septic shock, we investig

Intrinsic laryngeal muscles are spared from degeneration in the dy(3k)/dy(3k) mouse model of congenital muscular dystrophy type 1A.

Deficiency of laminin alpha2 chain leads to a severe form of congenital muscular dystrophy (MDC1A). Here, we analyzed whether the intrinsic laryngeal muscles (ILM) are spared in the dy(3K)/dy(3K) mouse model of complete laminin alpha2 chain absence. No muscle degeneration was evident; expression of various laminin chains was similar to that of limb muscles, and sustained integrin alpha7B expressio