Filtyp
Our preliminary data show high levels of adenosine in the blood of very low birth weight (VLBW) infants, positively correlating to their prematurity (i.e. body weight class). This prompted us to look for a mechanism promoting such impressive adenosine increase. We hypothesized a correlation with oxygen challenge. In fact, it is recognized that either oxygen lack or its excess contribute to the pat
Background: Maintaining and improving the quality of prosthetics and orthotics education at the Tanzania Training Centre for Orthopaedic Technologists is essential for the provision of appropriate prosthetics and orthotics services in African countries. Aim: To describe how Tanzanian and Malawian graduates’ of the Diploma in Orthopaedic Technology perceive their education and how it could be impro
Introduction: In Sierra Leone, West Africa, there are many people with disabilities in need of rehabilitation services after a long civil war. Sierra Leone is among the ten least developed countries in the world and half of the population live under the absolute poverty line with an income less than $1.25 a day. Aim: The aim of this qualitative study was to explore the experiences of prosthetic an
Introduction: Assistive technology is required to implement the Convention of Rights of Persons with Disabilities which asserts that all people with disabilities have the right to personal mobility and available and affordable assistive technologyAim: Investigate patients’ satisfaction with their lower-limb prosthetic or orthotic device and related service delivery in Malawi and Sierra Leone and t
Introduction: Few studies have investigated overall satisfaction with prostheses fabricated using low-cost technology. Evidence-based recommendations for prosthetic and orthotic services in low-income countries are needed in order to more effectively provide services. Detailed analysis of variables which influence patient satisfaction with assistive devices are therefore of interest to investigate
Danmark och Sverige skiljer sig åt i konstitutionella grundmodeller för den statliga förvaltningens ställning. Artikeln undersöker i rättsvetenskapligt perspektiv vad dessa skillnader betyder för utrymmet för politisk styrning av den statliga förvaltningen i fråga om organisation, styrning av olika slag samt kontroll. En slutsats är att de teoretiska konstitutionella modellerna inte ensamma bidrar
Background: Maintaining and improving the quality of prosthetics and orthotics education at the Tanzania Training Centre for Orthopaedic Technologists is essential for the provision of appropriate prosthetics and orthotics services in African countries.Objectives: To describe how Tanzanian and Malawian graduates’ of the Diploma in Orthopaedic Technology perceive their education and how it could be
Background: Little is known about the social and political factors that influence priority setting for different health services in low- and middle-income countries (LMICs), yet these factors are integral to understanding how national health agendas are established. We investigated factors that facilitate or prevent surgical care from being prioritized in LMICs. Methods and Findings: We undertook
Att leva med en autoimmun sjukdom som typ 1-diabetes innebär att man tvingas till ställningstaganden som en frisk individ sällan eller aldrig behöver ta i beaktande. Dessa ställningstaganden kan utifrån sett tyckas vara obetydliga men är för diabetikern livsviktiga. Denna artikel är skriven utifrån ett första-personsperspektiv och lyfter fram aspekter som blir en del i en slags överlevnadsstrategi
Objective: Generic substitution has contributed to economic savings but switching products may affect patient adherence, particularly among those using multiple medications. The aim was to analyse if use of multiple medications influenced the association between switching products and refill adherence to angiotensin-converting-enzyme (ACE) inhibitors in Sweden. Study Design and Setting: New users
Breast and ovarian cancer patients harboring BRCA1/2 germline mutations have clinically benefitted from therapy with PARP inhibitor (PARPi) or platinum compounds, but acquired resistance limits clinical impact. In this study, we investigated the impact of mutations on BRCA1 isoform expression and therapeutic response. Cancer cell lines and tumors harboring mutations in exon 11 of BRCA1 express a B
In this pilot study (RibaC), 58 hepatitis C virus (HCV) genotype 1 infected treatment-naïve patients were randomized to (i) 2 weeks ribavirin double dosing concomitant with pegylated interferon-α (pegIFN-α), (ii) 4 weeks ribavirin mono-therapy prior to adding pegIFN-α, or (iii) standard-of-care (SOC) ribavirin dosing concurrent with pegIFN-α. Four weeks of ribavirin mono-therapy resulted in a mean
Studies have causally linked external thyroid radiation exposure in childhood with thyroid cancer. In 1995, investigators conducted relative risk analyses of pooled data from seven epidemiologic studies. Doses were mostly 50 Gy. We pooled data from 12 studies of thyroid cancer patients who were exposed to radiation in childhood (ages
Background: At present a majority of older people remain in their ordinary homes. Research has generated knowledge about home and health dynamics and increased the awareness of the complexity of housing as related to ageing. As this knowledge is based mainly on research on very old, single-living people in ordinary housing there is a need to study other sub-groups of the ageing population. Thus, t
If we are to limit global warming to 2 °C, all sectors in all countries must reduce their emissions of GHGs to zero not later than 2060–2080. Zero-emission options have been less explored and are less developed in the energy-intensive basic materials industries than in other sectors. Current climate policies have not yet motivated major efforts to decarbonize this sector, and it has been largely p
Purpose – Scenarios have become a vital methodological approach in business as well as in public policy. When scenarios are used to guide analysis and decision-making, the aim is typically robustness and in this context we argue that two main problems at scenario set level is conservatism, i.e. all scenarios are close to a perceived business-as-usual trajectory and lack of balance in the sense of
Climate change is an important new challenge for local authorities. This study analyses the potential for using the Swedish mandatory process for risk and vulnerability analysis (RVA) as a vehicle to improve local climate adaptation work. An advantage with RVA is its comprehensive approach in dealing with all relevant threats and all vital functions of society. In order to test the applicability o
Mammography population screening has been implemented based on evidence of efficacy from randomized controlled trials (RCTs). Substantial technical developments have witnessed an evolution from screen-film mammography (SFM) to full-field digital mammography (FFDM), and more recently to digital breast tomosynthesis as a potential screening modality. Mammography's technical evolution calls for consi
Introduction Proton pump inhibitors (PPIs) are used as prophylaxis, guarding against anastomotic stricture (AS) in the aftermath of reconstructed esophageal atresia (EA). The incidence of stricture formation was studied in this setting, comparing outcomes of 3- and 12-month PPI prophylactic regimens. Patients and Methods Patient characteristics (gestational age, birth weight, prevalence of chromo
