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Hematopoietic stem cells (HSCs) are safeguarded from various threats such as stress, injury, or radiationwithin specialized microenvironments or niches within the bone marrow. In this thesis, we investigatedvarious facets of the bone marrow (BM) microenvironment and its critical role in hematopoiesis andrelated disorders.Initially, we elucidated the role of the Early Growth Response 1 (EGR1) gene
Control systems are ubiquitous and often at the core of Cyber-Physical Systems, like cars and aeroplanes. They are implemented as embedded software, that interacts in closed loop with the physical world through sensors and actuators. As a consequence, the software cannot just be tested in isolation. To close the loop in a testing environment and root causing failure generated by different parts of
Objectives: Genome-wide association studies have revealed over 200 genetic susceptibility loci for prostate cancer (PCa). By combining them, polygenic risk scores (PRS) can be generated to predict risk of PCa. We summarize the published evidence and conduct meta-analyses of PRS as a predictor of PCa risk in Caucasian men. Patients and methods: Data were extracted from 59 studies, with 16 studies i
Optimal growth and development in childhood and adolescence is crucial for lifelong health and well-being1–6. Here we used data from 2,325 population-based studies, with measurements of height and weight from 71 million participants, to report the height and body-mass index (BMI) of children and adolescents aged 5–19 years on the basis of rural and urban place of residence in 200 countries and ter
Polarized proton-proton collisions provide leading-order access to gluons, presenting an opportunity to constrain gluon spin-momentum correlations within transversely polarized protons and enhance our understanding of the three-dimensional structure of the proton. Midrapidity open-heavy-flavor production at s=200 GeV is dominated by gluon-gluon fusion, providing heightened sensitivity to gluon dyn
The planetary system around the naked-eye star v2 Lupi (HD 136352; TOI-2011) is composed of three exoplanets with masses of 4.7, 11.2, and 8.6 Earth masses (M⊕). The TESS and CHEOPS missions revealed that all three planets are transiting and have radii straddling the radius gap separating volatile-rich and volatile-poor super-earths. Only a partial transit of planet d had been covered so we re-obs
DEBATT. Vi bör undvika att kalla naturfenomen och väderhändelser för sådant som ”100-årsregn”, ”50-årsflöden” och liknande – det lägger grund för missförstånd om hur man bedömer riskerna, skriver forskarna Johanna Sörensen och Rolf Larsson, LTH.
Aims. DE Boo is a unique system, with an edge-on view through the debris disk around the star. The disk, which is analogous to the Kuiper belt in the Solar System, was reported to extend from 74 to 84 AU from the central star. The high photometric precision of the Characterising Exoplanet Satellite (CHEOPS) provided an exceptional opportunity to observe small variations in the light curve due to t
The relocation of the controversial Marine base at Futenma on Okinawa to Henoko in the north of the same island has been framed by Japanese politicians, officials, and analysts as crucial to deterrence. Critics respond that deterrence is merely a pretext, and the relocation is a politically convenient solution that perpetuates discrimination against Okinawa by the central government in Tokyo. This
Background: Patients with severe asthma may present with characteristics representing overlapping phenotypes, making them eligible for more than one class of biologic. Our aim was to describe the profile of adult patients with severe asthma eligible for both anti-IgE and anti-IL5/5R and to compare the effectiveness of both classes of treatment in real life. Methods: This was a prospective cohort s
Cabdio occidentalis, new species, is described from the Lake Mashkid basin and the Makran region of Iran. It is distinguished from other species of the genus by a combination of characters: 38–42+1–2 total lateral-line scales, 19–23 predorsal scales, 9–11 pectoral-fin rays, and the absence of a keel between the pelvic-fin base and the genital papilla. The cytochrome c oxidase subunit I (COI) seque
The study of atmospheric processes related to climate requires a multidisciplinary approach, encompassing physics, chemistry, meteorology, forest science, and environmental science. The Academy of Finland Centre of Excellence in atmospheric sciences (CoE ATM) responded to that need for 18 years and produced extensive research and eloquent results, which are summarized in this review. The work in t
The extent of vegetation openness in the temperate forest biome prior to modern humans is widely debated – particularly in Europe regarding baselines for conservation and restoration. The temperate forest biome was traditionally thought to be dense closed-canopy forest; however, this view has been challenged by arguments that large herbivores could have maintained some degree of openness, or even The extent of vegetation openness in past European landscapes is widely debated. In particular, the temperate forest biome has traditionally been defined as dense, closed-canopy forest; however, some argue that large herbivores maintained greater openness or even wood-pasture conditions. Here, we address this question for the Last Interglacial period (129,000–116,000 years ago), before Homo sapien
Climate change affects timing of reproduction in many bird species, but few studies have investigated its influence on annual reproductive output. Here, we assess changes in the annual production of young by female breeders in 201 populations of 104 bird species (N = 745,962 clutches) covering all continents between 1970 and 2019. Overall, average offspring production has declined in recent decade
Lifetime risk of developing breast cancer for Danish women is approx. 9%. Diagnostics are done by mammography, biopsy, and examination. Breast-conserving surgery followed by radiotherapy is standard for treatment of early-stage breast cancer. Studies report unsatisfying outcomes in up to one third of the patients. This review summarises the current surgical techniques. Oncoplastic breast surgery m
Importance: The prognostic impact of parenteral nutrition duration (PND) on retinopathy of prematurity (ROP) is not well studied. Safe prediction models can help optimize ROP screening by effectively discriminating high-risk from low-risk infants. Objective: To evaluate the prognostic value of PND on ROP; to update and validate the Digital ROP (DIGIROP) 2.0 birth into prescreen and screen predicti
This resource is a disaster risk financing conceptual framework to assist humanitarian donors, practitioners, and their partners (governments, local communities, etc.) to develop and implement more effective disaster risk financing activities.
